Morphology and morphometry of the reproductive organs in prepubertal and postpubertal male pigs exposed to di(2-ethylhexyl) phthalate before puberty: Precocious development of bulbourethral glands

Ljungvall, Karl; Veeramachaneni, D. N. Rao; Hou, Mi; Hultén, Fredrik; Magnusson, Ulf

doi:10.1016/j.theriogenology.2008.05.061

Cited by 15 publications

(11 citation statements)

References 23 publications

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“…The most frequent alterations are atrophy of testicles and hepatomegaly (David et al, 2000). In pigs, DEHP influences the function of bulbourethral glands (Ljungvall et al, 2003). During subacute toxicity, a proliferation of peroxizomes develops (Ortiz-Zarragoitia et al, 2006), and the induction of peroxisomal enzymes, changes in the lipid metabolism, inhibition of cholesterol synthesis and induction of fatty acid beta-oxidation may develop.…”

Section: Discussionmentioning

confidence: 99%

The distribution and accumulation of phthalates in the organs and tissues of chicks after the administration of feedstuffs with different phthalate concentrations

Jarošová¹,

Harazim²,

Suchý³

et al. 2009

Vet. Med.

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ABSTRACT:For the monitoring of distribution and accumulation of phthalic acid esters (PAE) in animal tissues, samples of muscle, mesenteric fat (fat), skin and liver from broiler chicks ROSS 308 were used. The chicks were divided into four groups (50 chicks each). All the chicks were given commercial diets (complete feed, KKS) for broiler chicks (starter -BR1; grower -BR2 and finisher -BR3). The experimental diets were supplemented with vegetable oil (RV) with low (group N) or high (group V) phthalate contents, or animal fat with a high phthalate content (group Z). Neither the control diets (K), nor the grower (BR1) diets contained vegetable oils or animal fat. The N chicks were given the grower (BR2) and finisher (BR3) diets supplemented with 5% and 3% vegetable oil, respectively. The V chicks were given BR2 and BR3 diets with 5% and 3% vegetable oil, respectively. The Z chicks were given BR2 and BR3 diets with 5% and 3% animal fat, respectively. The chicks were fattened till 42 days of age. Dibutyl phthalate (DBP) and di-(2-ethylhexyl) phthalate (DEHP) were found in the tissues of chicks in all the experimental groups. The DBP content in the muscle ranged from 0.03 to 0.55 mg/kg, in the adipose tissue from < 0.20 to 2.56 mg/kg, in the skin from < 0.20 to 1.49 mg/kg , and in the liver from 0.03 to 0.13 mg/kg. The content of DEHP in the muscle ranged from 0.03 to 1.15 mg/kg, in the adipose tissue from 0.25 to 9.85 mg/kg, in the skin from < 0.20 to 4.68 mg/kg, and in the liver from 0.16 to 0.24 mg/kg. The highest concentrations of DBP of 1.28 ± 1.00 mg/kg of fresh sample (an average value from eight chicks) was determined in the adipose tissue of V chicks. The highest concentration of DEHP of 3.27 ± 2.87 mg/kg of fresh sample (mean of eight chicks) was also determined in the V group. The accumulation of DEHP was 3.2; 2.6 and 2.9 times higher than that of DBP in the muscle, adipose tissue and skin, respectively. The V and Z chicks showed higher phthalate contents (the sum of DBP and DEHP) in the adipose tissue, skin and liver than the K and N chicks.

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Section: Discussionmentioning

confidence: 99%

The distribution and accumulation of phthalates in the organs and tissues of chicks after the administration of feedstuffs with different phthalate concentrations

Jarošová¹,

Harazim²,

Suchý³

et al. 2009

Vet. Med.

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“…Due to its low solubility in water, DEHP is then taken up and slowly released to the environment. While the DEHP molecule does not exist in nature, having only an industrial origin, several phthalic diesters occur as natural products [24][25][26]. The presence of carbonyl groups suggests that reactivity of DEHP may show some analogies with other natural molecules, such as amino acids, lipids and polysaccharides, commonly associated to cyanobacterial activity [27], or succinic acid and fumaric acid, both components of the citric acid cycle.…”

Section: Introductionmentioning

confidence: 99%

Binding of bis-(2-ethylhexyl) phthalate at the surface of hydrozincite nanocrystals: An example of organic molecules absorption onto nanocrystalline minerals

Sanna

Medas

Podda

et al. 2015

Journal of Colloid and Interface Science

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“…Synthetic phthalate esters are used commonly in paints and polymer products as plasticizers [6,7], and widely detected in the environments, such as sediments, natural waters, soils, plants, and aquatic organisms [8]. Although phthalate derivatives are useful chemicals, they are regarded as environmental health hazards due to their toxicity, carcinogenicity, teratogenicity, and mutagenicity [7,[9][10][11].…”

Section: Resultsmentioning

confidence: 99%

“…Phthalate exposure in childhood has also caused an increased occurrence of atopic disease including allergic rhinitis, wheezing, and eczema [9,15]. However, there are reports that phthalate esters are naturally produced extracellularly by microorganisms such as bacteria, fungi and yeasts [4,6,16]. Compounds 1-3 were isolated from the extract of the culture broth of plant-growth promoting rhizobacteria B. cepacia K87.…”

Section: Resultsmentioning

confidence: 99%

Natural Phthalate Derivatives from the Bacterium <i>Burkholderia cepacia</i> K87

Sultan¹,

Moon

Park

2009

J. Sci. Res.

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In continuation of our screening of antifungal active compounds from the fermentation extracts of soil borne bacteria Burkholderia cepacia K87 afforded three phthalate derivatives, dibutyl phthalate (1), dioctyl phthalate (2), and phthalate ester of alkylated 9-hydroxynonanoic acid (3). Compound 3 was reported first time. These phthalate derivatives were found to be marginally active or inactive against a number of bacteria and fungi.

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Morphology and morphometry of the reproductive organs in prepubertal and postpubertal male pigs exposed to di(2-ethylhexyl) phthalate before puberty: Precocious development of bulbourethral glands

Cited by 15 publications

References 23 publications

The distribution and accumulation of phthalates in the organs and tissues of chicks after the administration of feedstuffs with different phthalate concentrations

The distribution and accumulation of phthalates in the organs and tissues of chicks after the administration of feedstuffs with different phthalate concentrations

Binding of bis-(2-ethylhexyl) phthalate at the surface of hydrozincite nanocrystals: An example of organic molecules absorption onto nanocrystalline minerals

Natural Phthalate Derivatives from the Bacterium <i>Burkholderia cepacia</i> K87

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