Morphology and morphometry of lacrimal drainage system in relation to bony landmarks in Caucasian adults: a cadaveric study

Ali, Mohammad Javed; Schicht, Martin; Paulsen, Friedrich

doi:10.1007/s10792-017-0753-6

Cited by 22 publications

(17 citation statements)

References 12 publications

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“…Cadaveric measurements may be more accurate than radiological measurements. However, the cadaver studies have only been conducted in a small number of elderly population samples with an unknown history of lacrimal disease [2][3][4][5]. Most radiological studies were retrospective and examined the nasolacrimal anatomy of non-PANDO subjects using conventional axial CT. 6,8−11 All previous studies, except one 12 do not consider the bias that arose by including both eyes of the same individual in their analysis [2][3][4][5][6][7][8][9][10][11][13][14][15].…”

Section: Discussionmentioning

confidence: 99%

“…A relatively long, horizontally inclined, or narrow canal can slow the tear ow and predispose to in ammatory obstruction. The morphology of bony NLC has been previously studied in various radiological or cadaveric studies [2][3][4][5][6][7][8][9][10][11][12][13][14][15]. These studies reported inconsistent results about the dimensions of the NLC and its correlations with variables such as race, age, gender, and the presence of PANDO.…”

Section: Introductionmentioning

confidence: 99%

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Nasolacrimal canal morphology with or without idiopathic obstruction in Caucasian adults: a multidetector CT study

et al. 2022

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Purpose: To compare the morphological features of the bony nasolacrimal canal (NLC) in Caucasian adults with and without primary acquired nasolacrimal duct obstruction (PANDO).Methods: The study included one eye each from 38 patients with PANDO and 38 age-and gendermatched controls without PANDO, all of whom underwent multidetector computed tomography. In tomographic images, length, and orientation angles of the NLC, transverse canal diameters at the duct entrance and lower end, and minimum (narrowest) transverse and anterior-posterior canal diameters were measured.Results: The two groups were similar for NLC length and angulations. The transverse entrance diameter was signi cantly narrower in the PANDO group (mean, 4.6 mm vs. 5.1 mm) (p = 0.09). The narrowest site was most frequently in the middle duct or slightly above the middle in both groups (p > 0.05). The minimum canal diameters were signi cantly smaller in the PANDO group (p = 0.010 and p = 0.003). When gender subgroups were compared, the signi cant differences continued for the transverse entrance and minimum diameters in females with PANDO (p = 0.006) and for the minimum anterior-posterior diameter in males with PANDO (p = 0.02).Conclusion: Narrowness of the bony NLC may play a role in the etiopathogenesis of PANDO in adult Caucasians.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nasolacrimal canal morphology with or without idiopathic obstruction in Caucasian adults: a multidetector CT study

et al. 2022

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“…The morphometry of the NLD had been a subject of numerous cadaveric studies. [4,7,[11][12][13][14] These studies aimed to evaluate morphometric properties of the NLD in different populations using cadaveric specimens. Computed tomography studies purposed determining the NLD anatomy in different patient groups such as NLD obstructions and craniofacial malformations.…”

Section: Discussionmentioning

confidence: 99%

Morphometric evaluation of nasolacrimal duct

Erçakmak¹,

Vatansever²,

Demiryürek³

et al. 2021

Anatomy

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Objectives: Obstructions are very commonly seen in nasolacrimal duct before it opens into the inferior nasal meatus. Detailed anatomical knowledge of the nasolacrimal duct is crucial for physicians to understand the etiology of the obstructions, to plan ideal management option and to reduce unexpected iatrogenic injuries during surgeries. The aim of this study was to investigate morphometric properties of the nasolacrimal duct on computed tomography images. Methods: Three-dimensional computed tomography (3D-CT) of 142 adults (65 females, 77 males) were retrospectively evaluated. Antero-posterior cranial diameter, antero-posterior and transverse diameters and vertical angle of the nasolacrimal duct, distance between distal end of the nasolacrimal duct to anterior surface of the maxilla were measured and the differences evaluated statistically between right and left sides and among females and males and among different ages. All measurements were done using Osirix-Lite version 9 software. Results: None of the morphometric parameters of the nasolacrimal duct showed significant differences between right and left sides. Antero-posterior cranium and transverse diameter of the nasolacrimal duct were longer in men than women. Conclusion: Determining to morphometric properties of the nasolacrimal canal has advantages for understanding the etiology of the NLD obstructions, deciding the ideal surgical technique and reducing to unexpected injuries during surgeries related with this region.

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“…The front surface of the eye is the tear film. This liquid surface looks like a slow-moving “waterfall”, which continuously moves downwards, and drains into the nasolacrimal duct and the nasal cavity [ 17 ]. The film has a unique three-layered structure.…”

Section: Ocular Barriers That Limit the Bioavailability Of Topical Drugsmentioning

confidence: 99%

The Emerging Role of Topical Ocular Drugs to Target the Posterior Eye

Wang

Zhou

Zhang³

2021

Ophthalmol Ther

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The prevalence of chronic fundus diseases is increasing with the aging of the general population. The treatment of these intraocular diseases relies on invasive drug delivery because of the globular structure and multiple barriers of the eye. Frequent intraocular injections bring heavy burdens to the medical care system and patients. The use of topical drugs to treat retinal diseases has always been an attractive solution. The fast development of new materials and technologies brings the possibility to develop innovative topical formulations. This article reviews anatomical and physiological barriers of the eye which affect the bioavailability of topical drugs. In addition, we summarize innovative topical formulations which enhance the permeability of drugs through the ocular surface and/or extend the drug retention time in the eye. This article also reviews the differences of eyes between different laboratory animals to address the translational challenges of preclinical models. The fast development of in vitro eye models may provide more tools to increase the clinical translationality of topical formulations for intraocular diseases. Clinical successes of topical formulations rely on continuous and collaborative efforts between different disciplines.

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Morphology and morphometry of lacrimal drainage system in relation to bony landmarks in Caucasian adults: a cadaveric study

Abstract: This study provides useful anatomical and positional relationship of bony lacrimal landmarks and nasolacrimal duct in Caucasian adults.

Cited by 22 publications

References 12 publications

Nasolacrimal canal morphology with or without idiopathic obstruction in Caucasian adults: a multidetector CT study

Nasolacrimal canal morphology with or without idiopathic obstruction in Caucasian adults: a multidetector CT study

Morphometric evaluation of nasolacrimal duct

The Emerging Role of Topical Ocular Drugs to Target the Posterior Eye

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