Morphology and microstructure of subcortical structures at birth: A large-scale Asian neonatal neuroimaging study

Qiu, Anqi; Fortier, Marielle V.; Bai, Jiaojiao; Zhang, Xuejie; Chong, Yap Seng; Kwek, Kenneth; Saw, Seang‐Mei; Godfrey, Keith M.; Gluckman, Peter D.; Meaney, Michael J.

doi:10.1016/j.neuroimage.2012.09.032

Cited by 33 publications

(42 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the relationship of central fat deposition specifically to blood pressure, which is only one component of the metabolic syndrome, is not clear in children. Rapid weight gain during infancy (0–6 months) but not during early childhood (3–6 years) was associated with a higher metabolic risk score at age 17 years, but the association between waist circumference and blood pressure was not statistically significant in that study 18. Waist-for-height ratio in school children has not been found to confer additional discriminative power to BMI in some studies,19 20 but recently weight and weight-for-height changes through infancy and childhood have been associated with blood pressure at age 1021 and at age 9.1 and 15.5 years 22.…”

Section: Discussionmentioning

confidence: 56%

Association of early childhood abdominal circumference and weight gain with blood pressure at 36 months of age: secondary analysis of data from a prospective cohort study

et al. 2014

View full text Add to dashboard Cite

ObjectivesTo assess whether changes in measures of fat distribution and body size during early life are associated with blood pressure at 36 months of age.DesignAnalysis of data collected from a prospective cohort study.SettingCommunity-based investigation in Southampton, UK.Participants761 children with valid blood pressure measurements, born to women participating in the Southampton Women’s Survey.Primary and secondary outcome measuresAnthropometric measurements were collected at 0, 6, 12, 24 and 36 months and conditional changes between the time points calculated. Blood pressure was measured at 36 months. Factors possibly influencing the blood pressure were assessed using linear regression. All independent variables of interest and confounding variables were included in stepwise multiple regression to identify the model that best predicted blood pressure at 36 months.ResultsGreater conditional gains in abdominal circumference (AC) between 0–6 and 24–36 months were associated with higher systolic and diastolic blood pressures at 36 months (p<0.001). Subscapular skinfold and height gains were weakly associated with higher blood pressures, while greater weight gains between 0–6, 12–24 and 24–36 months were more strongly associated, but the dominant influences were AC gains, particularly from 0–6 to 24–36 months. Thus one SD score increases in AC between 0–6 and 24–36 months were associated with 1.59 mm Hg (95% CI 0.97 to 2.21) and 1.84 mm Hg (1.24 to 2.46) higher systolic blood pressures, respectively, and 1.04 mm Hg (0.57 to 1.51) and 1.02 mm Hg (0.56, 1.48) higher diastolic pressures, respectively.ConclusionsConditional gains in abdominal circumference, particularly within 6 months of birth and in the year preceding measurement, were more positively associated with blood pressure at 36 months than gains in other anthropometric measures. Above-average AC gains in early childhood may contribute to adult hypertension and increased cardiovascular disease risk.

show abstract

Section: Discussionmentioning

confidence: 56%

Association of early childhood abdominal circumference and weight gain with blood pressure at 36 months of age: secondary analysis of data from a prospective cohort study

et al. 2014

View full text Add to dashboard Cite

show abstract

“…The thalamus delineation from T2-weighted images and its accuracy were reported in our previous study (Qiu et al, 2013). DTI data were preprocessed as described previously (Qiu et al, 2013).…”

Section: Thalamus and Its Substructure Delineation Preprocessingmentioning

confidence: 99%

“…This hypoinnervation may underlie possible mechanisms of cortical gray matter reductions that have been observed in schizophrenic patients in adulthood. In addition, previous diffusion tensor imaging (DTI) studies showed that an increase in fractional anisotropy (FA) and decreases in axial diffusivity (AD) and radial diffusivity (RD) in the thalamus is in parallel with an increase FA in thalamic radiations, major white matter tracts for the thalamocortical connection (Aeby et al, 2009;Qiu et al, 2013). Altogether, there seems to be synchronous development among the thalamus, cortex, and their connectivity.…”

Section: Introductionmentioning

confidence: 96%

“…The thalamocortical circuitry undergoes rapid morphological growth to adapt to the needs of numerous sensorimotor, cognitive, and attentional functions in early life (Gilmore et al, 2012;Holland et al, 2014;Qiu et al, 2013). Thalamocortical dysconnectivity, both structural and functional, has been implicated in children with autism spectrum disorder (Nair et al, 2013), attention deficit hyperactivity disorder (ADHD; Bush, 2011;Van Ewijka et al, 2012), and schizophrenia (Jones, 1997;Woodward et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Developmental synchrony of thalamocortical circuits in the neonatal brain

Poh

Ratnarajah

et al. 2015

NeuroImage

Self Cite

View full text Add to dashboard Cite

“…Our neonatal imaging studies have resulted in the creation of an improved imaging atlas for the use of diffusion tensor and structural imaging in neonates [29]. We described the growth patterns and sexual dimorphism of deep grey matter structures during the neonatal period and filled the gap for normative references of healthy brain development in early infancy.…”

Section: Findings To Datementioning

confidence: 99%

Insights from the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) Cohort Study

Soh

Chong²,

Kwek³

et al. 2014

Ann Nutr Metab

Self Cite

View full text Add to dashboard Cite

Background: The dramatic emergence of noncommunicable diseases (NCD) in Asia, albeit with ethnic variation, has coincided with the rapid socioeconomic and nutritional transition taking place in the region, with the prevalence of diabetes rising 5-fold in Singapore in less than 4 decades. The Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort study recruited 1,247 expectant mothers of Chinese, Malay, or Indian ethnicity in their first trimester, with detailed longitudinal tracking - through the antenatal period, birth, and the child's first 4 years of life - to examine the potential roles of fetal, developmental, and epigenetic factors in early pathways to metabolic and neurodevelopmental outcomes. Key Messages: A number of findings with a translational and clinical focus have already emerged. In the mothers, we found that changes and differences in food consumption varied across ethnic groups, with persistence of traditional beliefs, during pregnancy and the postpartum period. During pregnancy, higher maternal glucose levels, even in the absence of gestational diabetes mellitus, had graded relations with infant adiposity. Relations between maternal emotional health and birth outcomes and neurodevelopment have been identified. Genotype (25%) and in particular gene × environment interactions (75%) shape interindividual variations in the DNA methylome at birth. The complex effects of fixed genetic variations and different in utero environments can influence the epigenetic status at birth and the later-life phenotype. Conclusions: The richness of the clinical data in 3 ethnicities, the extent of the biospecimen collection, and the extensive infancy and preschool follow-up have allowed us to study the biological pathways that link fetal development to health outcomes. In the coming years, more sophisticated analyses of epigenotype-phenotype relationships will become possible as the children grow and develop. Our studies will lead to the development of clinical and population-based interventions to reduce the burden of NCD.

show abstract

Morphology and microstructure of subcortical structures at birth: A large-scale Asian neonatal neuroimaging study

Cited by 33 publications

References 37 publications

Association of early childhood abdominal circumference and weight gain with blood pressure at 36 months of age: secondary analysis of data from a prospective cohort study

Association of early childhood abdominal circumference and weight gain with blood pressure at 36 months of age: secondary analysis of data from a prospective cohort study

Developmental synchrony of thalamocortical circuits in the neonatal brain

Insights from the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) Cohort Study

Contact Info

Product

Resources

About