Morphologisch-Experimentelle Untersuchungen �ber das diencephal-hypophys�re System im Verh�ltnis zum Wasserhaushalt

Ortmann, R.

doi:10.1007/bf01485534

Cited by 55 publications

(5 citation statements)

References 2 publications

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“…Experimentally induced osmoregulatory activity produces a variety of morphological changes in the SON neurons. The volumes of cells, nuclei, and nucleoli increase, the granules stainable with chrome alum hematoxylin phloxine and paraldehyde fuchsin are initially depleted, the Nissl substance is redistributed, and vacuolization of the cells and degenerative changes may occur after prolonged stress (Hillarp, 1949;Ortmann, 1950Ortmann, , 1951Laqueur, 1952;Leveque, 1953;Eichner, 1953;KovAcs et al, 1954;Bachrach, 1957;De Groot, 1957;Stutinsky, 1957;Eichner, 1958, 1960;Campanacci, 1960;Raiha, 1960;Sloper and King, 1963). An antagonism between the renal effects of adrenocortical and neurohypophyseal hormones has been suggested (Silvette and Britton, 1938; for references see Kennedy, 1960).…”

Section: Introductionmentioning

confidence: 99%

Respiration and Mitochondrial Content in Single Neurons of the Supraoptic Nucleus

Eneström

Hamberger

1968

The Journal of Cell Biology

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The study was undertaken to investigate the possible correlation of total volume of mitochondria per cell with the rate of succinate oxidation in isolated nerve cell bodies, after various functional stresses in the experimental animals. Significant cytological effects were found in the nerve cells of the supraoptic nucleus in rats which had been thirsting for 4-12 days or had been given 2% sodium chloride solution as a substitute for drinking water for a few weeks. Quantitation of mitochondria was done from electron micrographs. The cell volumes were calculated from sections of Epon-embedded tissue under phase-contrast microscopy. Succinate oxidation was measured on groups of 10 nerve cells with the microdiver technique. As a result of either thirst or sodium chloride load, the volume of mitochondria per nerve cell more than doubled. 'The rate of succinate oxidation was not changed after the rats had been thirsting but was enhanced by over 100% after they had drunk sodium chloride. A linear relationship was found for the amount of mitochondria versus respiration in the supraoptic neurons for all experimental groups except the thirsting animals. The mitochondria in the supraoptic neurons from thirsting animals were of the same size or smaller than those in controls, whereas in animals given sodium chloride solution the mitochondria were considerably enlarged. The observed effects were specific for the supraoptic nucleus.

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Section: Introductionmentioning

confidence: 99%

Respiration and Mitochondrial Content in Single Neurons of the Supraoptic Nucleus

Eneström

Hamberger

1968

The Journal of Cell Biology

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“…Experiments which have indicated a direct relationship between the amount of neurosecretory material and biologically active hormones have been conducted under basal conditions or have been of a long-term nature on dehydrated or lactating animals (Scharrer & Scharrer, 1954;Hild & Zetler, 1951Ortmann, 1950Ortmann, , 1951. Our present experiments have been designed to study changes that occur acutely, and demonstrate a decrease in the stainable material but no decrease in the vaso¬ pressin content of the rat posterior pituitary.…”

Section: Discussionmentioning

confidence: 85%

“…Under unstimulated conditions a parallel relationship exists between the amount of neurosecretory material and neurohypophysial hormones in different parts of the hypothalamo-hypophysial system (Scharrer & Scharrer, 1954;Hild & Zetler, 1951, and under conditions of chronic stimulation, e.g. water deprivation, the administration of hypertonic saline, or the polyuria of alloxan diabetes, there is a decreased amount of neurohypophysial neurosecretory material (Leveque & Scharrer, 1953;Gaunt, Lloyd & Chart, 1957), which is proportional to the decrease in vasopressin (Ortmann, 1950(Ortmann, , 1951 and oxytocin (Sawyer & Roth, 1953). Similarly, lactation decreases both the content of neurosecretory material in the neurohypophysis (Racadot, 1957;Rennels, 1958;Rinne, 1960), and that of vaso¬ pressin and oxytocin (Rennels, 1958;Heller, 1959).…”

Section: Introductionmentioning

confidence: 95%

Dissociation Between the Content of Vasopressin and Neurosecretory Material in the Rat Neurohypophysis

Moses¹,

Leveque²,

Giambattista³

et al. 1963

Journal of Endocrinology

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Vasopressin content and the staining of neurosecretory material with chrome-alum-haematoxylin-phloxin were observed in the neurohypophysis of rats following injection of formalin. The amount of neurosecretory material was reduced during the period up to 90 min. after formalin injection while no change in the vasopressin content was observed. These observations support the concept that the neurosecretory material is distinct from vasopressin and may be acting as a carrier or precursor for the hormones of the neurohypophysis.

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“…On the other hand, Legait (1955 a, b, c, 1959) found increased activity in the para ventricular and supraoptic nuclei in Rhode Island chickens during the breeding season using the size of the cell nucleus as a criterion for neurosecretory activity ; the amount of neurosecretory material and the morphological appearance of the neurosecretory granules were also taken into consideration. Ortmann (1950) and Ueno (1957) failed to find seasonal variations in the supraoptic and paraventricular nuclei of the albino rat.…”

Section: Introductionmentioning

confidence: 91%

Seasonal Changes in the Hypothalamohypophysial Neurosecretory System of Desert Rodents

Khalil¹,

Taufic²

1964

Journal of Endocrinology

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Seasonal changes in the content of neurosecretory material in the supra\ x=req-\ optic and paraventricular nuclei and in the pars nervosa of the desert rodents Jaculus jaculus (Oliv.) and Gerbillus gerbillus (Linn.) were followed and compared with those in the white rat kept under laboratory conditions. From the morphological characteristics it was concluded that neurosecretory activity in the desert rodent is minimal in December; signs of increased activity started in March, and maximal activity was reached in June. A decline of neurosecretory activity started in August and continued through the autumn season.In the laboratory white rat, on the other hand, the neurosecretory system showed low activity the whole year round. The quantity of neurosecretory material in the pars nervosa was less in summer than in winter.

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Morphologisch-Experimentelle Untersuchungen �ber das diencephal-hypophys�re System im Verh�ltnis zum Wasserhaushalt

Cited by 55 publications

References 2 publications

Respiration and Mitochondrial Content in Single Neurons of the Supraoptic Nucleus

Respiration and Mitochondrial Content in Single Neurons of the Supraoptic Nucleus

Dissociation Between the Content of Vasopressin and Neurosecretory Material in the Rat Neurohypophysis

Seasonal Changes in the Hypothalamohypophysial Neurosecretory System of Desert Rodents

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