Morphological Stages of Pilomatricoma

Kaddu, Steven; Soyer, H. Peter; Hödl, S; Kerl, Helmut

doi:10.1097/00000372-199608000-00001

Cited by 114 publications

(103 citation statements)

References 13 publications

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“…Tedavi cerrahidir. Bununla birlikte eksizyon sonrası % 2-6 oranında nüks bildirilmiştir 25 . Çalışmamızda pilomatriksoma saçlı deri kitleleri arasında görülme sıklığı % 3,2 olarak saptandı.…”

Section: Bulgularunclassified

Retrospective examine of subcutaneous nodular lesions occured on scalp

Yaldız¹,

Yaldız²,

Ceylan³

2013

Sakarya Med J

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Giriş: Derinin selim tümörleri klinik pratikte sık gözlenen patolojilerdendir. Saçlı deri, derinin selim tümörlerinin yerleşimi açısından sık görülen bölgelerden birisidir. Derinin histolojik yapısını oluşturan farklı hücrelerden çok sayıda selim tümör oluşabilmektedir. Trikilemmal kist, epidermal kist ve lipom, saçlı deride subkutan nodüle neden olan tümoral lezyonlardandır. Bu çalışmada, 52 hastada, saçlı deri yerleşimli ve total eksize edilen 62 subkutan nodül retrospektif olarak incelenmiştir. Findings: 27 (51,9 %) of the patients were female, and 25 (48,1 %) were male. The mean age was found as 47,5 (ages 21-82). 34 (54,8 %) lesions were revealed as trichilemmal cysts, 16 (25,8 %) of them were revealed as lipomas and 8 (12,4 %) of them were found as epidermoid cysts, the rest of the pathologies were 2 (3,2 %) pilomatrixomas, and 2 (3,2 %) fibrolipomas. Result: Our study signified that trichilemmal cysts are the most common subcutaneous nodules that occures on scalp. Additionally, lipomas and epidermoid cysts were the other common subcutanous scalp lesions that can be seen in clinical practice.

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Section: Bulgularunclassified

Retrospective examine of subcutaneous nodular lesions occured on scalp

Yaldız¹,

Yaldız²,

Ceylan³

2013

Sakarya Med J

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“…Ultimately, the lesion eventuates as a so-called 'ancient' pilomatricoma with a florid foreign body reaction and abundant calcification in the adjacent stroma. 90,91 Metaplastic bone formation in these lesions may subsequently ensue. A perforating variant of the pilomatricoma is uncommonly seen, whereby the necrotic material and shadow cells are extruded through the epidermis or through a hair follicle.…”

Section: Histopathologymentioning

confidence: 99%

“…In contrast, pilomatrix carcinoma shows broad geographic necrosis with an infiltrative margin and cytological alterations, including fully transformed malignant change. 90,91,[103][104][105][106][107][108][109][110][111][112][113][114][115] Matrical differentiation may only be focal in these lesions. Tumors have the potential to spread to regional lymph nodes and produce fatal disseminated metastatic disease.…”

Section: Clinical Featuresmentioning

confidence: 99%

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Malignant adnexal neoplasms

2006

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Malignant cutaneous adnexal neoplasms are one of the most challenging areas of dermatopathology. Tumors of the pilosebaceous apparatus can occur as single-lineage neoplasms or may manifest as complex proliferations with multilineal differentiation patterns including not only the germinative component of the hair bulb, the inner or outer root sheath epithelium and the sebaceous gland and duct, but also the sweat duct components that relate to the apocrine secretory apparatus which empties into the follicle near the follicular bulge. Eccrine and apocrine neoplasms present a bewildering array of morphologies, which often defy precise classification. The purpose of this review is to discuss in detail the malignant neoplasms of the cutaneous adnexae and their benign and prognostically indeterminate mimics. Modern Pathology (2006) 19, S93-S126. doi:10.1038/modpathol.3800511Keywords: eccrine carcinoma; sebaceous neoplasia Malignant tumors of the pilosebaceous apparatus, their mimics and precursors IntroductionTumors of the pilosebaceous unit can occur in isolation or in combination with complex proliferations showing multilineal differentiation patterns encompassing those of sweat ducts, epidermis and stroma with its varied components. In this review, we will focus upon the malignant adnexal proliferations, considering benign entities mainly insofar as they impact the diagnostic approach to adnexal carcinoma. We will first turn to the malignant sebaceous neoplasms, their precursors and their mimics. Sebaceous adenoma Clinical FeaturesThe sebaceous adenoma is a benign neoplasm that manifests clinically as a pale yellow nodular lesion, typically of the face, that expresses itself clinically after the age of 50. Tumors range in size from o1 to 45 cm. [1][2][3][4][5][6] These lesions are associated with the Muir-Torre syndrome, comprising the coexpression of cutaneous neoplasms, including those of sebaceous type with well-differentiated squamous epithelial neoplasms, and visceral malignancies, including carcinomas of the breast, ovary, gastrointestinal tract and larynx. [7][8][9][10][11][12][13][14] An occasional patient may manifest a malignant lymphoma of nodal or extranodal type. 10,12,14 Sebaceous neoplasms in the setting of Muir-Torre syndrome are often difficult to classify, showing overlap features between all of the prototypic forms of sebaceous neoplasm ranging from hyperplasia to carcinoma. 13 HistologyThe prototypic sebaceous adenoma manifests 1-2 layers of germinitive cells which mature to form central sebocytes, and have an architecture comprising a sharply circumscribed sebaceous lobule surrounded by a compressed pseudocapsule of dermal stroma ( Figure 1a). The overlying epidermis may be attenuated, but sometimes forms a collarette around the peripheral aspect of the neoplasm. Unlike sebaceous hyperplasia, occasional mitoses may be seen in the lobules of a sebaceous adenoma and in concert with this nucleoli may be somewhat prominent, but the pleomorphism, hyperchromasia and individual cell necrosis of the se...

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“…Pilomatricoma, a skin adnexal tumor that recapitulates hair growth, [1][2][3] is by far the most common epithelial neoplasm of childhood. 4 The proliferating cells in pilomatricoma seem distinctly programmed to undergo terminal differentiation and death, which is perhaps responsible for the tumor's inevitably benign clinical course.…”

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confidence: 99%

Trisomy 18 is a consistent cytogenetic feature in pilomatricoma

Agoston

Liang

Richkind³

et al. 2010

Modern Pathology

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Pilomatricoma, also known as 'calcifying epithelioma of Malherbe', is a common skin adnexal tumor that mimics hair growth. Its proliferating cells seem distinctly programmed to undergo terminal differentiation and death. We report the first cytogenetic investigations of pilomatricoma. Trisomy 18 was shown, in an index case, by G-banded karyotyping. This aberration was corroborated by interphase fluorescence in situ hybridization, using a chromosome 18 pericentromeric probe, in the basaloid epithelial component of 7 of 11 pilomatricomas, including the index case. Trisomy 18 was present in a small subset of cells, suggesting a role in pilomatricoma progression, rather than in tumor initiation. We conclude that trisomy 18 is a consistent feature in pilomatricoma, suggesting that genes carried on this chromosome, such as that for the antiapoptotic oncoprotein BCL2, may have a role in the growth and differentiation of this benign self-limited tumor.

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Morphological Stages of Pilomatricoma

Cited by 114 publications

References 13 publications

Retrospective examine of subcutaneous nodular lesions occured on scalp

Retrospective examine of subcutaneous nodular lesions occured on scalp

Malignant adnexal neoplasms

Trisomy 18 is a consistent cytogenetic feature in pilomatricoma

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