Hydroxyapatite and its compounds are important and promising inorganic biomaterials that can be used in dentistry and bone surgery due to its biocompatibility with the bone tissue of a living organism. The paper presents the synthesis of carbonate-substituted hydroxyapatite powders and studies their morphology, physical and chemical characteristics and biocompatibility in vivo. The synthetic carbonate-substituted hydroxyapatite are biocompatible, and they do not cause degenerative changes in the surrounding tissues. The result of this research suggests that the carbonate-substituted hydroxyapatite is promising biomaterial for orthopedic and dental prosthetics.