“…Later, several more cases of lacrimal puncta and canaliculi obliteration were described in the patients, getting local therapy with mitomycin C, including those not associated with an obvious toxic-allergic reaction. [39][40][41] Meanwhile, mitomycin C is relatively often used in lacrimal surgery practice to prevent excessive fibrosis of the ostium after surgery, [42][43][44][45] there is fundamental evidence on tear ducts and nasal mucosal fibroblasts [46][47][48] and therefore it is impossible to draw an unambiguous conclusion about an obligate and specific toxic effect of this cytostatic agent on the tear ducts. '…”