Morphological features of regenerative processes after dacryocystorinostomy with the use of mitomycin C

Nasolacrimal Duct Obstruction in the Patients Receiving Treatment for Cancer

“…Later, several more cases of lacrimal puncta and canaliculi obliteration were described in the patients, getting local therapy with mitomycin C, including those not associated with an obvious toxic-allergic reaction. [39][40][41] Meanwhile, mitomycin C is relatively often used in lacrimal surgery practice to prevent excessive fibrosis of the ostium after surgery, [42][43][44][45] there is fundamental evidence on tear ducts and nasal mucosal fibroblasts [46][47][48] and therefore it is impossible to draw an unambiguous conclusion about an obligate and specific toxic effect of this cytostatic agent on the tear ducts. '…”