Morphological control and molecular recognition by bis-urea hydrogen bonding in micelles of amphiphilic tri-block copolymers

Abstract

Hydrogen bonding between urea groups of amphiphilic tri-block copolymers considerably affects their self-assembly in water, which results in a strong modification of morphology and viscosity of aqueous solutions; the hydrogen bonding motif in these amphiphilic copolymers allows molecular recognition of small molecules with complementary hydrogen bonding units.

Hydrogen bonded supramolecular polymers in protic solvents: role of multitopicity

“…Therefore the presence of large anisotropic self-assemblies is expected. [3][4][5] This was confirmed by cryoTEM and SANS analyses. Fig.…”

A One‐Pot Synthesis of Symmetrical and Unsymmetrical Dipeptide Ureas

“…The usefulness of ureas in materials chemistry, [1][2][3] pharmaceutical chemistry, [4][5][6] and biology [7,8] is evident from the publication of many more than a thousand papers reporting their synthesis and applications. These diverse series of compounds have wide series of applications ranging from plasticisers to pharmaceuticals.…”

Fabrication of novel hepatoma-targeting microdisks by hydrogen bond-assisted self-assembly of an azacitidine-conjugating amphiphilic random copolymer

“…Our aim is to realize the fabrication of novel nano-or microstructures by the self-assembly of amphiphilic random copolymers. Among the reported terms that affect the assembly morphologies of amphiphilic copolymers, in addition to the block length of the copolymers and the assembly conditions [16,17], are noncovalent interactions, such as hydrogen bond interactions, which have also been applied as a powerful tool for the construction of novel nano-or microstructures [18][19][20].…”