Morphological changes in the venous wall under experimental neoplastic intoxication

Abstract

Annotation. The goal of this study was to investigate the characteristic histological and morphological signs of changes in the venous wall as one of the main pathogenetic links of thrombosis in oncological pathology. Assessment of these changes is necessary to understand the process of occurrence and prevention of thromboembolic and thrombotic complications in patients with oncological diseases. Histological, submicroscopic and polarizing materials of hind limb veins of 11 mature nonlinear male rats weighing 170-180 g on day 30 of chronic neoplastic intoxication complicated by deep limb vein thrombosis were studied. It is established that experimental neoplastic intoxication in rats on histological examination was accompanied by the development of submicroscopic reorganization of endotheliocytes and their desquamation, platelet ligation as one of the causes of future thrombotic complications. Thus installed the negative effect of long-term neoplastic intoxication on the cells and all layers of the venous vascular wall as well as on the blood forming elements was studied. A close connection between the presence of the obtained changes against the background of oncological diseases and the development of such thrombotic complications as phlebothrombosis, pulmonary embolism and thrombophlebitis has been established. The development of complications shows that the prevention of thrombosis is an important component of conservative therapy of cancer patients, to prevent the development of lethal outcomes. High incidence of PE, deep vein thrombosis and thrombophlebitis in the superficial venous system emphasizes the use of preventive means of conservative treatment of cancer patients to prevent these complications, resulting in a high mortality rate. The study of morphological changes of the venous wall under the influence of chronic neoplastic intoxication in experimental conditions allows to carry out a detailed analysis of possible complications.

The Effect of Smoking on the Indicators of Glutathione-Dependent Enzymes of Oral Fluid in Teenagers and Young Adults

“…Патогенез захворювань тканин пародонту складний та багаторівневий; його важливою ланкою є посилення перекисного окиснення ліпідів (ПОЛ), ослаблення АОСЗ, а також порушення всіх обмінних процесів, характерних для цього захворювання, під дією різноманітних чинників, у тому числі під впливом паління [3,5,7,10,14,15,18]. Крім того, порушення в системі ПОЛ -АОЗС є основою патогенезу ендогенної інтоксикації, що ускладнює перебіг багатьох захворювань, у тому числі захворювань тканин пародонту [2,4,12,13] «Art of Medicine» ферменту ГПО. При цьому утворюються нешкідливі органічні спирти (R-OH), які далі окиснюються, а ГS-SГ відновлюється до вихідного рівня за допомогою НАДФН-залежної ГР.…”