Morphological changes in human gastric tumours after eradication therapy of Helicobacter pylori in a short-term follow-up

Abstract

SUMMARYBackground: It is controversial as to whether the development of gastric cancer is influenced by Helicobacter pylori eradication. If eradication itself influences the tumour morphology, this may affect the tumour discovery rate. Aim: To investigate the morphological changes in the gastric neoplasm after H. pylori eradication. Methods: We studied 37 patients with eradication therapy. After a 1-month follow-up, endoscopic re-evaluation was performed and the appearance was compared with first image. All lesions were resected endoscopically, and were subjected to histological assessment and to immunohistochemistry.

A Comparative Study of White Light Endoscopy, Chromoendoscopy and Magnifying Endoscopy with Narrow Band Imaging in the Diagnosis of Early Gastric Cancer after Helicobacter pylori Eradication

“…Gastric cancer found after H. pylori eradication appears with indistinct forms, such as tiny and flattened lesions [6][7][8]. Histopathological findings of gastric cancer after H. pylori eradication are characterized as either regenerating non-tumorous epithelium covering over the tumorous tissue and/or surface differentiation of tumors [8][9][10], which may confuse endoscopic as well as histologic diagnosis [7,9,10]. This evidence suggests that EGC after H. pylori eradication might need alternative diagnostic strategy for the precise endoscopic diagnosis.…”

“…However, gastric cancer is discovered in patients even after successful H. pylori eradication [5]. Moreover, H. pylori eradication influences the clinicopathological features of gastric tumors, including macro-and microscopic appearances [6][7][8][9][10]. Gastric cancer found after H. pylori eradication appears with indistinct forms, such as tiny and flattened lesions [6][7][8].…”

“…Moreover, H. pylori eradication influences the clinicopathological features of gastric tumors, including macro-and microscopic appearances [6][7][8][9][10]. Gastric cancer found after H. pylori eradication appears with indistinct forms, such as tiny and flattened lesions [6][7][8]. Histopathological findings of gastric cancer after H. pylori eradication are characterized as either regenerating non-tumorous epithelium covering over the tumorous tissue and/or surface differentiation of tumors [8][9][10], which may confuse endoscopic as well as histologic diagnosis [7,9,10].…”

Endoscopic Detection of Gastric Carcinoma After Helicobacter pylori Eradication: More Difficult or Just Hype?

“…The characteristics of post-eradication GC include: (a) detection *40 months after eradication; (b) lesions are histologically well differentiated; (c) gross lesion morphology is depressed; and (d) the lesions are small (10-20 mm diameter). Pathologically, the Ki-67 index and Wnt5a expression are significantly reduced [1,11]. In some patients, the mucosa surrounding the lesion is obscured [11], possibly due to the flattening of the tumor tissue, with formation of non-neoplastic foveolar epithelium as the outermost layer.…”

“…Pathologically, the Ki-67 index and Wnt5a expression are significantly reduced [1,11]. In some patients, the mucosa surrounding the lesion is obscured [11], possibly due to the flattening of the tumor tissue, with formation of non-neoplastic foveolar epithelium as the outermost layer.…”