Repurposing existing drugs approved for other conditions is crucial to identifying speci c therapeutics against SARS-CoV-2 causing COVID-19 (coronavirus disease-2019) pandemic. Towards this attempt, it is important to understand how this virus hijacks the host system during the course of infection and determine potential virus-and host-targeted inhibitors. This study elucidates the underlying virus-host interaction based on differentially expressed gene pro ling, functional enrichment and pathway analysis, protein-protein and protein-drug interactions utilizing the information on transcriptional response to SARS-CoV-2 infection from GSE 147507 dataset containing COVID-19 case relative to healthy control and infected cell culture compared to uninfected one. Low IFN signaling, chemokines level elevation, and proin ammatory cytokines release were observed markedly. We identi ed MYC-rapamycin and ABCG2rapamycin interactions, and unique gene signatures in case (regulation of protein modi cation and MAPK signaling) as well as in cell (metabolic dysregulation and interferon signaling) different from known COVID-19 genes. Highlights Low IFN signaling, chemokines level elevation, and proin ammatory cytokines release were observed markedly Cyclosporine, doxycycline, chloroquine, rapamycin interacted with MYC, PPP3R1, FOS, ABCG2, TNF in case and culture Cyclosporine, azithromycin, rapamycin, oseltamivir interacted with IL6, CD8A, CD40LG, IL10, CSF3 known COVID-19 genes Chloroquine, lopinavir, ritonavir, interferon beta-1a antagonist are included in WHO solidarity trial for COVID-19 Among a plethora of repurposable drugs those appearing here with unique gene signatures might be