2018
DOI: 10.1016/j.micron.2017.11.001
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Morphological changes in erythrocytes of people with type 2 diabetes mellitus evaluated with atomic force microscopy: A brief review

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Cited by 21 publications
(15 citation statements)
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“…Remodeling is consistently linked to risk factors such as diabetes and hypertension and involves capillary rarefaction and narrowing of capillaries and intramural arterioles. Notably, some of these risk factors is also associated with modified blood cell biophysics, such as increased RBC stiffness and adhesiveness in diabetes ( 94 ). This stiffness and adhesion change exacerbates microvascular obstruction, although much remains to be learned about blood cell biophysics in the context of CMD.…”
Section: Minding the Gap: Bridging Engineering And Microvascular Researchmentioning
confidence: 99%
“…Remodeling is consistently linked to risk factors such as diabetes and hypertension and involves capillary rarefaction and narrowing of capillaries and intramural arterioles. Notably, some of these risk factors is also associated with modified blood cell biophysics, such as increased RBC stiffness and adhesiveness in diabetes ( 94 ). This stiffness and adhesion change exacerbates microvascular obstruction, although much remains to be learned about blood cell biophysics in the context of CMD.…”
Section: Minding the Gap: Bridging Engineering And Microvascular Researchmentioning
confidence: 99%
“…Therefore, the erythrocyte deformability is impaired by elevated membrane rigidity, increased internal viscosity or several kinds of shape changes alone or in concert [14,15]. In literature, morphological changes in diabetic erythrocytes have been reported in atomic force microscopic investigation, which include decreased biconcave depth, diameter and height [3]. Diabetic erythrocyte membrane shows phospholipid peroxidation and decreased membrane ion-transporting enzymatic activities [16].…”
Section: Discussionmentioning
confidence: 99%
“…Diabetes is associated with various hemorheologic disorders, i.e., these include platelet activation and increased whole blood viscosity and plasma viscosity. With respect to erythrocytes, morphology is changed, and deformability tends to decrease [2,3]. The deformability of erythrocytes passing through microvasculature is a prerequisite of microcirculation, and this deformability in diabetic patients has been so far investigated.…”
Section: Introductionmentioning
confidence: 99%
“…Glucose oxidation and protein glycation, caused by diabetes-associated hyperglycemia, can induce several [29] found that high glucose concentrations resulted in the glycosylation of erythrocyte membranes, thereby stiffening the glycosylated cell membranes and reducing the deformability of erythrocytes. Loyola et al [30] observed the deformability of erythrocytes via atomic force microscopy. Their results indicated that the deformability of erythrocytes in patients with DM was reduced, and their subsequent rigidity made them difficult to pass through the microvessels and led to microcirculation disturbance.…”
Section: Deformabilitymentioning
confidence: 99%