Morphological, antibacterial, and cell attachment of cellulose acetate nanofibers containing modified hydroxyapatite for wound healing utilizations

Elsayed, Mardia T.; Hassan, Abeer A.; Abdelaal, Said A.; Taher, Mohamed M.; Ahmed, M.K.; Shoueir, Kamel R.

doi:10.1016/j.jmrt.2020.09.094

Cited by 49 publications

(22 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, silver nanoparticles exhibit a lower antibacterial activity compared to the ionic form of silver and are vulnerable to oxidation, which may adversely modify the composite structure and disable the tuning effects enabled by the use of Ag as a dopant. Therefore, we surmise that the doping of MNPs with Ag ions may not diminish their biocompatibility while endowing them with an antibacterial activity, which they otherwise do not possess at considerable levels in the pure form [ 38 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

Nanofibrous ε-polycaprolactone scaffolds containing Ag-doped magnetite nanoparticles: Physicochemical characterization and biological testing for wound dressing applications in vitro and in vivo

Ahmed

Zayed

El-Dek

et al. 2021

Bioactive Materials

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Nanofibrous ε-polycaprolactone scaffolds containing Ag-doped magnetite nanoparticles: Physicochemical characterization and biological testing for wound dressing applications in vitro and in vivo

Ahmed

Zayed

El-Dek

et al. 2021

Bioactive Materials

View full text Add to dashboard Cite

“…(2021) states that following compositional modification, cellulose acetate nanofibers containing modified HA for wound healing utilization demonstrated a high degree of response with proliferation and growing behaviors. 30 Samadian HA, et al (2018) used HA modification dressing that resulted in the highest collagen synthesis, re-epithelialization, neovascularization, and cosmetic appearance, according to histological and histomorphometric examinations of the wounds. 31 Wardhana AS, et al use ellagic-hydroxyapatite acid to promotes osteogenesis in bone defects by increasing the amounts of osteoblasts and therefore the expression of osteoprotegerin and osteocalcin.…”

Section: Discussionmentioning

confidence: 99%

Pre-Clinical Study: Immunohistochemical evaluation of matrix metalloproteinase-13 on rabbit (Oryctolagus cuniculus) socket healing after application of platelet-rich fibrin with and without hydroxyapatite

Damayanti

Rachmawati

2022

F1000Res

View full text Add to dashboard Cite

Background: Tissue engineering technology has been used globally and proven to accelerate wound healing. This study aimed to analyse the effect of adding hydroxyapatite (HA) as a scaffold to platelet-rich fibrin (PRF) as a growth factor in accelerating the wound healing process as seen from the expression of matrix metalloproteinase-13 (MMP-13). Methods: This research is an animal experiment conducted on 18 rabbits (Oryctolagus cuniculus). Rabbits were randomly divided into the following three groups of treatment: (G1) the application of PRF group, (G2) the application of PRF+HA group and (C) the control group without any application. Furthermore, each treatment group was split randomly into three groups of observation time. Periodontal tissue biopsy was performed to analyse the histopathological features that were examined on the basis of the level of MMP-13 immunoexpression. Results: MMP-13 immunoexpression in the PRF+HA group showed better histoscore results, indicating a substantial reduction in MMP-13 values compared with other groups. The healing process was shown to increase with increasing observation time (p<0.05), and the PRF+HA group outperformed the PRF and control groups. On day 3, MMP-13 exhibited a dark brown colour of Immunohistochemistry (IHC), which indicated an increase in the expression value of MMP-13 in the early stages of healing, namely, inflammation. On day 14, light brown IHC was seen, especially in group 2, as a reference that the remodeling process had begun. Conclusions: This study indicates that the application of HA can accelerate the socket healing process by decreasing the level of immunoexpression of MMP-13. HA is an alloplastic material that has inherent bioactive properties that support osteoconduction, which functions as a scaffold in the form of a fibrin matrix that can bind MMPs so that it can accelerate the wound healing process.

show abstract

“…GQDs are a very promising substrate for drug delivery systems because of their excellent tunable chemical and physical properties, as well as the simple surface functionalization. Otherwise, there are dozens of published articles used as antimicrobial and anticancer treatments [20,39,[166][167][168][169]. The size-dependent coupling of graphene nanosheets with DNA molecules was reported that GQDs have a limited lateral dimension and the capacity of DNA molecules to intercalate is most apparent.…”

Section: Drug Delivery Formulating Systemsmentioning

confidence: 99%

“…Various methods of synthesis can account for the major difference in chemical structure and scale. Thus, it is important to recognize the connection between dimensional variation depending on the synthesis process and optical properties in terms of applied and fundamental perspectives [38,39]. A fascinating report of the GQDs synthetic process was primarily evaluated on the size-dependent photoluminescence properties and the quantum size effect of GQDs [40].…”

Section: Introductionmentioning

confidence: 99%

Outstanding Graphene Quantum Dots from Carbon Source for Biomedical and Corrosion Inhibition Applications: A Review

et al. 2021

Self Cite

View full text Add to dashboard Cite

Graphene quantum dots (GQD) is an efficient nanomaterial composed of one or more layers of graphene with unique properties that combine both graphene and carbon dots (CDs). It can be synthesized using carbon-rich materials as precursors, such as graphite, macromolecules polysaccharides, and fullerene. This contribution emphasizes the utilization of GQD-based materials in the fields of sensing, bioimaging, energy storage, and corrosion inhibitors. Inspired by these numerous applications, various synthetic approaches have been developed to design and fabricate GQD, particularly bottom-up and top-down processes. In this context, the prime goal of this review is to emphasize possible eco-friendly and sustainable methodologies that have been successfully employed in the fabrication of GQDs. Furthermore, the fundamental and experimental aspects associated with GQDs such as possible mechanisms, the impact of size, surface alteration, and doping with other elements, together with their technological and industrial applications have been envisaged. Till now, understanding simple photo luminance (PL) operations in GQDs is very critical as well as there are various methods derived from the optical properties of manufactured GQDs can differ. Lack of determining exact size and morphology is highly required without loss of their optical features. Finally, GQDs are promising candidates in the after-mentioned application fields.

show abstract

Morphological, antibacterial, and cell attachment of cellulose acetate nanofibers containing modified hydroxyapatite for wound healing utilizations

Cited by 49 publications

References 51 publications

Nanofibrous ε-polycaprolactone scaffolds containing Ag-doped magnetite nanoparticles: Physicochemical characterization and biological testing for wound dressing applications in vitro and in vivo

Nanofibrous ε-polycaprolactone scaffolds containing Ag-doped magnetite nanoparticles: Physicochemical characterization and biological testing for wound dressing applications in vitro and in vivo

Pre-Clinical Study: Immunohistochemical evaluation of matrix metalloproteinase-13 on rabbit (Oryctolagus cuniculus) socket healing after application of platelet-rich fibrin with and without hydroxyapatite

Outstanding Graphene Quantum Dots from Carbon Source for Biomedical and Corrosion Inhibition Applications: A Review

Contact Info

Product

Resources

About