Morphological and neurochemical differentiation of large granular layer interneurons in the adult rat cerebellum

Geurts, Frederik J.; Timmermans, Jean‐Pierre; Shigemoto, Ryuichi; Schutter, Erik De

doi:10.1016/s0306-4522(01)00058-6

Cited by 90 publications

(90 citation statements)

References 57 publications

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“…In addition to their axonal projection, immunoreactivity for calretinin and their innervation by recurrent Purkinje cell axons provide convincing arguments to classify these cells indeed as Lugaro cells (Laine and Axelrad 2002). Apparently these cells are identical to "Golgi-like" calretinin-positive but mGluR2-negative cells described by Geurts et al (2001), although the two reports diVer as to whether these cells are preferentially found in the more superWcial (Laine and Axelrad 2002)or deeper parts (Geurts et al 2001) of the granule cell layer.…”

Section: Large Inhibitory Interneurons Of the Granule Cell Layermentioning

confidence: 96%

Besides Purkinje cells and granule neurons: an appraisal of the cell biology of the interneurons of the cerebellar cortex

Schilling

Oberdick

Rossi

et al. 2008

Histochem Cell Biol

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Ever since the groundbreaking work of Ramon y Cajal, the cerebellar cortex has been recognized as one of the most regularly structured and wired parts of the brain formed by a rather limited set of distinct cells. Its rather protracted course of development, which persists well into postnatal life, the availability of multiple natural mutants, and, more recently, the availability of distinct molecular genetic tools to identify and manipulate discrete cell types have suggested the cerebellar cortex as an excellent model to understand the formation and working of the central nervous system. However, the formulation of a unifying model of cerebellar function has so far proven to be a most cantankerous problem, not least because our understanding of the internal cerebellar cortical circuitry is clearly spotty. Recent research has highlighted the fact that cerebellar cortical interneurons are a quite more diverse and heterogeneous class of cells than generally appreciated, and have provided novel insights into the mechanisms that underpin the development and histogenetic integration of these cells. Here, we provide a short overview of cerebellar cortical interneuron diversity, and we summarize some recent results that are hoped to provide a primer on current understanding of cerebellar biology.

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Section: Large Inhibitory Interneurons Of the Granule Cell Layermentioning

confidence: 96%

Besides Purkinje cells and granule neurons: an appraisal of the cell biology of the interneurons of the cerebellar cortex

Schilling

Oberdick

Rossi

et al. 2008

Histochem Cell Biol

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“…In an attempt to further characterize this phenotype, we performed antisomatostatin immunohistochemistry identifying Golgi cells as a likely neuronal population affected (arrows in Fig. 6 C and D) (36). ErbB4 is expressed within the granule cell layer, but it remains unconfirmed in large interneurons (37).…”

Section: Aberrant Cranial Neural Crest Migration and Cranial Nerve Armentioning

confidence: 99%

Neural and mammary gland defects in ErbB4 knockout mice genetically rescued from embryonic lethality

Tidcombe

Jackson-Fisher

Mathers

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

237

279

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Mice lacking the epidermal growth factor receptor family member ErbB4 exhibit defects in cranial neural crest cell migration but die by embryonic day 11 because of defective heart development. To examine later phenotypes, we rescued the heart defects in ErbB4 mutant mice by expressing ErbB4 under a cardiac-specific myosin promoter. Rescued ErbB4 mutant mice reach adulthood and are fertile. However, during pregnancy, mammary lobuloalveoli fail to differentiate correctly and lactation is defective. Rescued mice also display aberrant cranial nerve architecture and increased numbers of large interneurons within the cerebellum.

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“…The neuron of Lugaro (NL; also known as intermediate neuron or horizontal neuron) Figure 1 has been described in the GL of various species of mammals, including humans (Lugaro, 1894;Fox, 1959;Braak and Braak, 1983;Lainé and Axelrad, 1996;Geurts et al, 2001;Flace et al, 2004;MelikMusian and Fanardzhyan, 2004). The body of the NL is distributed in all cerebellar lobes and lobules, localized in the external zone of the GL just beneath the Purkinje neuron layer.…”

Section: Neuron Of Lugaromentioning

confidence: 99%

“…Other markers of the NL are 60 G. Ambrosi et al the cytoplasmic antigen rat-303 (Sahin and Hockfield, 1990) and the calcium binding protein calretinin (Geurts et al, 2001).…”

Section: Neuron Of Lugaromentioning

confidence: 99%

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The Fathers of Italian Histology

ISH¹

2009

Eur J Histochem

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Subscriptions, cancellations, business correspondence and any enquiries must be sent to the Tipografia PIME Editrice srl, Pavia, Italy. Cancellations must be received before the end of September to take effect at the end of the same year.No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means (electronic, electrostatic, magnetic type, mechanical, photocopying or otherwise) without written permission by the Publishers.Reg. Tribunale di Pavia n. 289/23.2.1984. Supported by the Ministero per i Beni e le Attività Culturali, Italy as a publication of high cultural value.Associato all'USPI Unione Stampa Periodica Italiana Disclaimer. Whilst every effort is made by the publishers and the editorial board to see that no inaccurate or misleading data, opinion or statement appears in this journal, they wish to make it clear that the data and opinions appearing in the articles or advertisements herein are the responsibility of the contributor or advisor concerned. Accordingly, the publisher, the editorial board and their respective employees, officers and agents accept no liability whatsoever for the consequences of any inaccurate or misleading data, opinion or statement. The Journal publishes original papers, technical reports, letters to the editor, review articles concerning investigations performed with the aid of biophysical, biochemical, molecular-biological, enzymatic, immunohistochemical, cytometric, and image analysis techniques. Areas of particular interest to the European Journal of Histochemistry include: -functional cell and tissue biology in animals and plants; -cell differentiation and death; -cell-cell interaction and molecular trafficking; -biology of cell development and senescence; -nerve and muscle cell biology; -cellular basis of diseases During this period, Carlo Rizzoli established the experimental approach for the study of the molecular basis of cell differentiation in vitro, anticipating some aspects of the present investigation on the potentiality of stem cells. Furthermore, Carlo Rizzoli was one of the first Italian scientists to publish its scientific reports in large-diffusion international journals, thus contributing to the world-wide diffusion of the seminal studies on the in vitro cell differentiation models. Editor-in-ChiefIn 1961, Carlo Rizzoli became Professor of Histology and general embryology and, since 1964 to 1999, Director of the Institute of Histology at the University of Bologna.The initial steps of this undertaking were challenging, since in 1963, following the recruitment of Oliviero Mario Olivo at the Chair of Human Anatomy, the facilities of the Institute of Histology were almost nonexistent. In few years, however, Carlo Rizzoli was able to organize an efficient research group of motivated young collaborators that included Paolo Carinci, Lia Guidotti, Francesco Antonio Manzoli, capable of introducing original and seminal lines of research into the national and international histological arena. In this way, a numb...

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Morphological and neurochemical differentiation of large granular layer interneurons in the adult rat cerebellum

Cited by 90 publications

References 57 publications

Besides Purkinje cells and granule neurons: an appraisal of the cell biology of the interneurons of the cerebellar cortex

Besides Purkinje cells and granule neurons: an appraisal of the cell biology of the interneurons of the cerebellar cortex

Neural and mammary gland defects in ErbB4 knockout mice genetically rescued from embryonic lethality

The Fathers of Italian Histology

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