Morphological and molecular characterization of Distichochlamys citrea M.F. Newman in Bach Ma National Park, Thua Thien Hue Province, Vietnam

Chen, Tran Van; Tuan, Nguyen Duc; Triet, Nguyen Thanh; An, Nguyen Hoang; NGUYEN, PHAN THI THAO; Hai, Nguyen Thi Thanh; NHI, NGUYEN THANH TO; Co, Nguyen Quang; NHI, HO THI HOANG; HUONG, HOANG VIET; Phuong, Truong Thi Bich; Nhung, Nguyen Thi Ai

doi:10.13057/biodiv/d230442

Cited by 3 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A voucher specimen (DC-10.19) has been stored at the Laboratory of the Traditional Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam. 5,53…”

Section: Plant Materialsmentioning

confidence: 99%

Phytochemical Constituents Isolated From Distichochlamys citrea M.F. Newman Rhizomes and Their Antioxidant and α-glucosidase Inhibitory Activities

Chen

Thông

Trung

et al. 2023

Natural Product Communications

Self Cite

View full text Add to dashboard Cite

Objective/Background: Distichochlamys citrea M.F. Newman (Zingiberaceae) is an endemic plant of Vietnam and has been used as a folk medication for treatments of infection-related diseases, diabetes, and used as spice. This study aimed to characterize the antioxidant and α-glucosidase inhibitory activities of isolated compounds from D. citrea rhizomes. Methods: Compounds have been isolated from D. citrea rhizomes by different chromatographic techniques. Their chemical structures were determined based on mass spectrometry and nuclear magnetic resonance spectroscopy in comparison with those reported in the literature. The antioxidant effect was evaluated by 2,2-diphenyl-1-picrylhydrazyl-free radical neutralization whereas α-glucosidase inhibitory activity was determined by using the method of optical density measurement. Results: Seven compounds including 5-hydroxy-3,7,4'-trimethoxyflavone (1), kaempferol (2), platyphyllone (3), 5- O-caffeoylquinic acid (4), a mixture of phytosterols ( β-sitosterol (5) and stigmasterol (6)), and glycerol monostearate (7) were isolated and identified from D. citrea rhizomes. Compounds 1 and 2 simultaneously exhibited antioxidant activities (IC50 = 794.71 ± 2.68 µM, 14.08 ± 5.60 µM, respectively) and α-glucosidase inhibitory effects (IC50 = 189.40 ± 1.55 µM, and 31.86 ± 5.38 µM, respectively). Meanwhile, compound 3 and the mixture of 5 and 6 singly inhibited the enzyme α-glucosidase (IC50 = 69.41 ± 6.11 µM, 1204.82 µM, respectively), and showed weak antioxidant effects. On the contrary, compound 4 only had antioxidant activity (IC50 = 30.20 ± 1.86 µM). Compound 7 did not exhibit either antioxidant or enzymatic inhibitory effects. Conclusion: This is the first time that all of the seven compounds (1-7) and their biological activities were reported from D. citrea. Moreover, the α-glucosidase inhibitory effect of platyphyllone (3) is reported for the first time in the literature. This study revealed that flavonoids, phenolics, sterols, and monoglycerides in D. citrea rhizomes could be responsible for the antioxidant property and α-glucosidase inhibitory effect of this Vietnamese endemic medicinal plant.

show abstract

“…A voucher specimen (DC-10.19) has been stored at the Laboratory of the Traditional Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam. 5,53…”

Section: Plant Materialsmentioning

confidence: 99%

Phytochemical Constituents Isolated From Distichochlamys citrea M.F. Newman Rhizomes and Their Antioxidant and α-glucosidase Inhibitory Activities

Chen

Thông

Trung

et al. 2023

Natural Product Communications

Self Cite

View full text Add to dashboard Cite

show abstract

“…Prof. Truong Thi Bich Phuong (Department of Biology, University of Sciences, Hue University). DNA‐based identification was carried out in our previous work for molecular characterization [ 20 ] and approved for deposition at GenBank under the code MZ310840.1. (https://www.ncbi.nlm.nih.gov/nuccore/MZ310840.1).…”

Section: Methodsmentioning

confidence: 99%

“…The objective of this work is to specify the most promising candidates for isomaltase-based inhibition, conducive to the extended efforts on more in-depth specification. DNA-based identification was carried out in our previous work for molecular characterization [20] and approved for deposition at GenBank under the code MZ310840.1. (https://www.ncbi.nlm.nih.gov/nuccore/MZ310840.…”

Section: Introductionmentioning

confidence: 99%

Identification of potential oligo‐1,6‐glucosidase inhibitors in Distichochlamys citrea M.F. Newman essential oil

Bui,

Hai,

et al. 2023

Vietnam Journal of Chemistry

View full text Add to dashboard Cite

Distichochlamys citrea M.F. Newman, a genus endemic to Vietnam, has been known by folk experiences for its biological potential, including antidiabetics. The essential oil was extracted and characterized by gas chromatography‐mass spectrometry for compositional specificity. The data was used as input for computational predictions. Gas chromatography‐mass spectrometry analysis revealed the presence of 23 natural components in the essential oil (C1‐C23); major constituents: α‐citral (C16; 21.19%), cineole (C7; 16.11%), β‐citral (C14; 16.03%), geranyl acetate (C20; 15.97%), geraniol (C15; 10.74%). Density functional theory calculation suggests C14 and C15 highly promising for intermolecular interactions by on their electronic configurations. Molecular docking simulation predicts the most effective inhibitors against PDB‐3AJ7 (oligo‐1,6‐glucosidase) into the order of ligand‐protein complexes: C15‐3AJ7 (DS ‐11.9 kcal.mol‐1) ≈ C14‐3AJ7 (DS ‐11.8 kcal.mol‐1) > C12‐3AJ7 (DS ‐11.5 kcal.mol‐1) > C11‐3AJ7 (DS ‐11.2 kcal.mol‐1) > C9‐3AJ7 (DS ‐11.0 kcal.mol‐1). All the components are expected to be biocompatible (by QSARIS physical properties) and safe for medicinal use (by ADMET pharmacokinetics and pharmacology). Altogether, the results encourage further consideration of D. citrea M.F. Newman essential oil for further wet antidiabetic tests, especially the specification on C14 (aka. β‐Citral) and C15 (aka. Geraniol).

show abstract

Comparison of the effect of two categories of Arthrospira platensis polysaccharides (exo and endopolysaccharides) on tomato growth: Effect on morphological, histological and biochemical plant growth traits

et al. 2023

View full text Add to dashboard Cite

Morphological and molecular characterization of Distichochlamys citrea M.F. Newman in Bach Ma National Park, Thua Thien Hue Province, Vietnam

Cited by 3 publications

References 0 publications

Phytochemical Constituents Isolated From Distichochlamys citrea M.F. Newman Rhizomes and Their Antioxidant and α-glucosidase Inhibitory Activities

Phytochemical Constituents Isolated From Distichochlamys citrea M.F. Newman Rhizomes and Their Antioxidant and α-glucosidase Inhibitory Activities

Identification of potential oligo‐1,6‐glucosidase inhibitors in Distichochlamys citrea M.F. Newman essential oil

Comparison of the effect of two categories of Arthrospira platensis polysaccharides (exo and endopolysaccharides) on tomato growth: Effect on morphological, histological and biochemical plant growth traits

Contact Info

Product

Resources

About