Morphological and Molecular-Biological Features of Inflammatory and Regeneratory Processes in Peridont Tissues with Periimplantitis and Periodontitis

Aa, Kulakov; Коган, Е. А.; Brailovskaya, T.V.; Vedyaeva, Anna; Zharkov, N.V.

doi:10.1134/s1607672920030060

Cited by 5 publications

(3 citation statements)

References 13 publications

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“…They share common etiopathogenic mechanisms that lead to the development of inflammatory periodontal lesions in response to oral bacterial consortia with alveolar bone loss as their main hallmark. While periodontal lesions in periodontitis and peri-implantitis comprise the marginal periodontal supporting tissues, the target of apical periodontitis are the peri-radicular periodontal tissues [89][90][91]. In this context, the striking role of VEGF in angiogenesis might relate to the formation of granulation tissue in destructive periodontal lesions [92], nutrient level restoration and immune cell migration [71].…”

Section: Inflammatory Diseases Affecting Periodontal Tissuesmentioning

confidence: 99%

“…On the other hand, peri-implantitis is the inflammation of the adjacent soft and hard tissues surrounding a dental implant. In a similar manner to periodontitis, it is clinically characterized by bleeding, increased pocket formation and suppuration, resulting from polymicrobial anaerobic infection that leads to rapid bone resorption and implant failure [91,97,98].…”

Section: Periodontitis and Peri-implantitismentioning

confidence: 99%

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Vascular Endothelial Growth Factor: A Translational View in Oral Non-Communicable Diseases

et al. 2021

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Vascular endothelial growth factors (VEGFs) are vital regulators of angiogenesis that are expressed in response to soluble mediators, such as cytokines and growth factors. Their physiologic functions include blood vessel formation, regulation of vascular permeability, stem cell and monocyte/macrophage recruitment and maintenance of bone homeostasis and repair. In addition, angiogenesis plays a pivotal role in chronic pathologic conditions, such as tumorigenesis, inflammatory immune diseases and bone loss. According to their prevalence, morbidity and mortality, inflammatory diseases affecting periodontal tissues and oral cancer are relevant non-communicable diseases. Whereas oral squamous cell carcinoma (OSCC) is considered one of the most common cancers worldwide, destructive inflammatory periodontal diseases, on the other hand, are amongst the most prevalent chronic inflammatory conditions affecting humans and also represent the main cause of tooth loss in adults. In the recent years, while knowledge regarding the role of VEGF signaling in common oral diseases is expanding, new potential translational applications emerge. In the present narrative review we aim to explore the role of VEGF signaling in oral cancer and destructive periodontal inflammatory diseases, with emphasis in its translational applications as potential biomarkers and therapeutic targets.

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Section: Inflammatory Diseases Affecting Periodontal Tissuesmentioning

confidence: 99%

Section: Periodontitis and Peri-implantitismentioning

confidence: 99%

Vascular Endothelial Growth Factor: A Translational View in Oral Non-Communicable Diseases

et al. 2021

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“…Of particular interest is the peri-implant mucositis, which precedes the peri-implantitis. Here, a biofilm-induced inflammatory process is initiated, leading to improper protein adsorption, elevated inflammatory response due to the presence of microbes, and activation of pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs), leading to thick fibrous capsule formation and implant failure (depicted in Figure S1ii). The prevalence of such adverse conditions such as peri-implant mucositis was noted in 63.4% of individuals and 30.7% of implants, while peri-implantitis was noted in 18.8% of individuals and in 9.6% of failed implants …”

Section: Introductionmentioning

confidence: 99%

Mesoporous Silk-Bioactive Glass Nanocomposites as Drug Eluting Multifunctional Conformal Coatings for Improving Osseointegration and Bactericidal Properties of Metal Implants

Moses

Mandal

2022

ACS Appl. Mater. Interfaces

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Endowing metal implants with multifunctional traits to prevent implant-associated infections and improve osseointegration has become a pivotal facet in orthopedics and dental fixation. Herein, we report the synthesis of mesoporous 70S bioactive glass–silk fibroin nanocomposites inspired by the biomimetic organo-apatites of mineralized collagen. The mesoporous, biomimetic nanocomposites enabled loading of antibiotics (gentamicin and doxycycline) and favored their release in a rapid manner while preserving their bioactivity. Ease in modification of the mesoporous nanocomposites enabled tailoring of 3-(aminopropyl)-triethoxysilane to the silanol network of bioactive glass, which improved the loading capacity of the hydrophobic drug (dexamethasone). The modification favored the slow and sustained release of dexamethasone from the modified mesoporous nanocomposites, which is desired for mediating osteogenesis and immunomodulation. Conformal coatings of these drug-loaded nanocomposites were materialized on stainless-steel implants through a facile electrophoretic deposition (EPD) technique, wherein the deposition yield can be controlled by applied parameters. Antibiotic coatings exhibited antibacterial efficacy with bioactivity retained up to 28 days, while dexamethasone-loaded coatings favored mesenchymal stem cell adhesion and osteoinduction. The immunomodulatory roles were also ascertained, wherein M2 macrophage biasness was favored in dexamethasone-loaded coatings. The versatility of these mesoporous biomimetic nanocomposites guarantee the loading of scenario-specific drugs to aid their local delivery through the conformal EPD coatings developed over metal implants toward improving implant patency.

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Histopathological characterization of peri-implant diseases: A systematic review and meta-analysis

Shafizadeh

Amid

Mahmoum

et al. 2021

Archives of Oral Biology

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Morphological and Molecular-Biological Features of Inflammatory and Regeneratory Processes in Peridont Tissues with Periimplantitis and Periodontitis

Cited by 5 publications

References 13 publications

Vascular Endothelial Growth Factor: A Translational View in Oral Non-Communicable Diseases

Vascular Endothelial Growth Factor: A Translational View in Oral Non-Communicable Diseases

Mesoporous Silk-Bioactive Glass Nanocomposites as Drug Eluting Multifunctional Conformal Coatings for Improving Osseointegration and Bactericidal Properties of Metal Implants

Histopathological characterization of peri-implant diseases: A systematic review and meta-analysis

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