Morphologic analysis of false negative SurePath^® slides using Focalpoint™ GS computer‐assisted cervical screening technology: An Australian experience

Abstract

These morphological features are illustrated to help identify HSIL and HG glandular lesions when viewing the FOV presented by the FocalPoint(TM) GS technology.

Negative Pap tests in women with high‐grade cervical lesions on follow‐up biopsies: Contributing factors and role of human papillomavirus genotyping

“…As expected, the majority of women with HGCL on biopsy tested positive for hrHPV (92%). These findings are similar to those published by Katki et al 9 who [10][11][12] Our results along with those of previous studies raise questions regarding the effectiveness of mandatory routine 10% rescreening. In an effort to reduce the false-negative rate of the Pep test, several investigators have proposed focused rescreening.…”

“…15 This could significantly undermine the value of Pap test as the overinterpretation may jeopardize the specificity of cytology test for SIL. Nevertheless, the focused rescreening strategy for hrHPV-positive NILM population could be significantly improved with reasonable modifications by requiring additional cytologic features that are commonly observed in misinterpreted cases, such as marked obscuring inflammation or hyperchromatic groups(HCG), as demonstrated in the current and previous studies [10][11][12]. As previously mentioned, focused rescreening of NILM Pap tests based on positive hrHPV tests could generate a large rescreening workload depending on the HPV prevalence of given populations.…”

Low-Grade Squamous Intraepithelial Lesion or High-Grade Squamous Intraepithelial Lesion? Concordance Between the Interpretation of Low-Grade Squamous Intraepithelial Lesion and High-Grade Squamous Intraepithelial Lesion in Papanicolaou Tests: Results From the College of American Pathologists PAP Education Program

“…These characteristics have been described previously as influencing the interpretation of cytologists. [9][10][11] High-grade squamous intraepithelial lesion cells may have had more cytoplasm, mimicking metaplasia, or slides may have had abundant LSIL cells. In routine practice, some of these slides may be classified as ASCcannot exclude HSIL (ASC-H), but in the educational setting, participants might be inclined to label these cases as LSIL because ASC-H and other atypical responses are not options on the answer form.…”

Reliability of reporting the presence of transformation zone material in Papanicolaou smears using an automated screening system

“…have shown that the successful detection of abnormalities depends on the combined resources of the screening device and screener's vigilance and expertise . It has been shown that the primary screening system FocalPointTM potentially demonstrates high sensitivity when detecting high‐grade lesions (both squamous and glandular) . FocalPoint is limited in its skills to accurately determine the presence of TZM .…”

“…Although many studies have demonstrated or compared both types of automated screening systems (primary and/or interactive systems), in terms of the sensitivity in detecting squamous and even atypical glandular lesions in the literature, we were unable to find studies that evaluated the reliability of reporting the presence of endocervical and/or metaplastic cells using automated screening devices …”