Morphologic abnormalities observed in retina, pancreas and kidney of diabetic Chinese hamsters

Abstract

Summary. Intraeellular glycogen deposits were consistently found in the retina, kidney and pancreatic islets of diabetie-ketonurie Chinese hamsters. Accumulation of glycogen in the outer nuclear layer of the retina was mostly associated with severity of the disease, but was not related to age or sex. The type of retinal cell involved in the accumulation of glycogen was not clearly established. Itowever, the position of the affected cell, side by side with retinal neurons, suggests that the glycogen deposits were within Miiller cells. These giant glias normally synthesize and store glycogen. All ketonuric Chinese hamsters examined showed some accumulation of glycogen in distal tubules of the kidney. This abnormal glycogen was not found in glueosurie non-ketonurie or in nondiabetic Chinese hamsters. Variable amounts of glycogen were found in fl cells of pancreatic islets of diabetic hamsters, as reported by others. I-iowever, accumulation of glycogen was also found in ~ and D islet cells from 2 middle aged Chinese hamsters with long term glueosuria and recent ketonuria. Abnormal glucose and glycogen metabolism seem to play an important role in the pathogenesis of diabetes in the Chinese hamster.

The Chinese Hamster as a Model for the Study of Diabetes Mellitus

“…Therefore, glucose, glucose + arginine, and K + fail to cause normal release while theophylline and IBMX act more normally. Since excess amounts of glycogen are found in the diabetic B-cell, 58 Frankel has suggested that the relatively normal insulin responses to theophylline and IBMX might be due to synergism between cAMP and glucose derived from the large amount of intracellular glycogen. 5 The role of somatostatin in the pancreas of the diabetic Chinese hamster is not clear.…”

Antioxidant Protective Effect of Glibenclamide and Metformin in Combination with Honey in Pancreas of Streptozotocin-Induced Diabetic Rats

“…Diabetes mellitus is associated with progressive metabolic derangement, worsening glycemic control and morphological changes in the kidney, retina, pancreas and other organs [1–3]. Oxidative stress is known to play a significant role in the induction of these processes [4,5].…”

Antidiabetics in combination with hydroxychloroquine improve antioxidant and hepatoprotective activities in alloxan-induced diabetic rats

“…Diabetes mellitus is associated with progressive metabolic derangement, worsening glycemic control and morphological changes in the kidney, retina, pancreas and other organs (Soret et al, 1974;Cristina et al, 2008;Cook et al, 2005). Oxidative stress is known to play a significant role in the induction of these processes (Giugliano et al, 1996;Baynes and Thorpe, 1999).…”