Morphofunctional changes in the kidneys of mice with the use of adaptogens against the background of physical exertion

Abstract

When performing maximum physical activity, the main role for maintaining motor activity and homeostasis of the animal body is given to the kidneys. In this regard, the purpose of our research is to study morphological changes in the body of laboratory animals during physical exertion and the use of biologically active substances. One of the first to carry out a comprehensive assessment of the histological changes in experimental animals when given adaptogens (tincture of moral root, pantocrine and a combination of the same drugs with oats) against the background of maximum loads. The dosage of adaptogens was calculated according to the method proposed by Clark, based on the live weight of the animals. Which was 2 μl at the beginning of the experiment, subsequently the dosage was increased to 6 μl for all experimental groups. The first group was given distilled water, and the experimental group received leuzea tincture and oatsol. Ovesol was poured in a dose of 4 μl from 22 to 26 days. The total duration of the experiment was 28 days. It was also found that the use of tincture of moral root (safflower leuzea) and pantocrine prior to physical exertion makes it possible to correct histological changes.