Morphine sex-dependently induced place conditioning in adult Wistar rats

Karami, Manizheh; Zarrindast, Mohammad Reza

doi:10.1016/j.ejphar.2007.12.010

Cited by 64 publications

(32 citation statements)

References 57 publications

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“…There are sex differences and strain differences in the rewarding properties of morphine, but female rodents generally also show more opioid reward than male rodents. In Wistar rats, low doses of morphine are more rewarding to females than to males (Karami and Zarrindast, 2008). In Sprague-Dawley rats, however, there is no difference in morphineinduced CPP between males and females at lower doses, but females continue to display CPP at high doses of morphine that males do not prefer (Cicero et al, 2000).…”

Section: Sex Differences In Drug Abusementioning

confidence: 85%

Sex Differences in Animal Models: Focus on Addiction

2016

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Section: Sex Differences In Drug Abusementioning

confidence: 85%

Sex Differences in Animal Models: Focus on Addiction

2016

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“…In animals, females self-administer heroin and morphine more than males, and acquire heroin faster on self-administration paradigms (Carroll et al, 2004; Cicero et al, 2003; Lynch and Carroll, 1999). Females also show a greater preference for morphine during CPP (Cicero et al, 2003; Karami and Zarrindast 2008). Several opioid receptors, particularly the mu-opioid receptors (MORs), have been implicated in opioid dependence (for review see Chartoff and Connery, 2014).…”

Section: Sudmentioning

confidence: 99%

Sex-dependent mental illnesses and mitochondria

Shimamoto

Rappeneau

2017

Schizophrenia Research

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The prevalence of some mental illnesses, including major depression, anxiety-, trauma-, and stress-related disorders, some substance use disorders, and later onset of schizophrenia, is higher in women than men. While the higher prevalence in women could simply be explained by socioeconomic determinants, such as income, social status, or cultural background, extensive studies show sex differences in biological, pharmacokinetic, and pharmacological factors contribute to females’ vulnerability to these mental illnesses. In this review, we focus on estrogens, chronic stress, and neurotoxicity from behavioral, pharmacological, biological, and molecular perspectives to delineate the sex differences in these mental illnesses. Particularly, we investigate a possible role of mitochondrial function, including biosynthesis, bioenergetics, and signaling, on mediating the sex differences in psychiatric disorders.

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“…In self administration studies, females are consistently found to acquire psychostimulant self administration more quickly and at lower doses than males (Lynch, & Carroll, 1999; Hu, Crombag, Robinson, & Becker, 2004; Roth, Cosgrove, & Carroll, 2004). Females also develop a conditioned place preference to several drugs of abuse at lower doses and with fewer pairings than males (Russo et al, 2003; Mathews, & McCormick, 2007; Karami, & Zarrindast, 2008; Zakharova, Wade, & Izenwasser, 2009). Circulating gonadal hormones also influence self-administration and drug-primed reinstatement.…”

Section: Individual Vulnerability To the Effects Of Addictive Drugs Omentioning

confidence: 99%

Aberrant learning and memory in addiction

Torregrossa

Corlett

Taylor

2011

Neurobiology of Learning and Memory

201

157

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Over the past several years, drug addiction has increasingly been accepted to be a disease of the brain as opposed to simply being due to a lack of willpower or personality flaw. Exposure to addictive substances has been shown to create enduring changes in brain structure and function that are thought to underlie the transition to addiction. Specific genetic and environmental vulnerability factors also influence the impact of drugs of abuse on the brain and can enhance the likelihood of becoming an addict. Long-lasting alterations in brain function have been found in neural circuits that are known to be responsible for normal appetitive learning and memory processes and it has been hypothesized that drugs of abuse enhance positive learning and memory about the drug while inhibiting learning about the negative consequences of drug use. Therefore, the addict's behavior becomes increasingly directed towards obtaining and using drugs of abuse, while at the same time developing a poorer ability to stop using, even when the drug is less rewarding or interferes with functioning in other facets of life. In this review we will discuss the clinical evidence that addicted individuals have altered learning and memory and describe the possible neural substrates of this dysfunction. In addition, we will explore the preclinical evidence that drugs of abuse cause a progressive disorder of learning and memory, review the molecular and neurobiological changes that may underlie this disorder, determine the genetic and environmental factors that may increase vulnerability to addiction, and suggest potential strategies for treating addiction through manipulations of learning and memory.

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Morphine sex-dependently induced place conditioning in adult Wistar rats

Cited by 64 publications

References 57 publications

Sex Differences in Animal Models: Focus on Addiction

Sex Differences in Animal Models: Focus on Addiction

Sex-dependent mental illnesses and mitochondria

Aberrant learning and memory in addiction

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