Morphine or its withdrawal affects plasma malondialdehyde, vitamin E levels and absence or presence of abstinence signs in rats

Pinelli, A; Cighetti, Giuliana; Trivulzio, Silvio; Accinni, R.

doi:10.1211/jpp.61.04.0011

Cited by 4 publications

(1 citation statement)

References 32 publications

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“…при абстиненции, усиленного высвобождения катехоламинов из депо не происходит, но сохраняется их ускоренный синтез, как следствие появляется избыточная концентрация метаболитов катехоламинов (адреналина, норадреналина и дофамина). Вследствие изменения активности ферментов в биологических жидкостях и тканях (главным образом в мозге) накапливается дофамин [6][7][8]. Именно этот процесс обусловливает развитие таких основных клинических признаков абстинентного синдрома, как высокая тревожность, напряженность, возбуждение, подъем артериального давления, учащение пульса, появление других вегетативных расстройств, нарушения сна и др.…”

Section: оригинальные и обзорные статьиunclassified

The diagnostic importance of the concentration balance of metabolites of catecholamines and serotonin in patients with heroin and amphetamine addiction and withdrawal syndrome

Glagovsky¹,

Lyang²,

Кочетов³

2017

Lab. sluzh.

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В настоящее время одной из важнейших медико-социальных проблем в России становится алкогольная и наркотическая зависимость. В последние годы отмечается значительное увеличение распространенности различных наркоманий, причем темп роста этих заболеваний очень высок и превышает

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Section: оригинальные и обзорные статьиunclassified

The diagnostic importance of the concentration balance of metabolites of catecholamines and serotonin in patients with heroin and amphetamine addiction and withdrawal syndrome

Glagovsky¹,

Lyang²,

Кочетов³

2017

Lab. sluzh.

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Bergenin decreases the morphine-induced physical dependence via antioxidative activity in mice

et al. 2014

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Oxidative stress plays a role in the development of physical dependence induced by morphine. Bergenin, a polyphenol found in many Asian, African, and South American medicinal plants, is a potent antinarcotic agent with wide spectrum of pharmacological activities including antioxidant action. In the present study, we observed that bergenin decreased the development of physical dependence induced by morphine in mice and the antioxidant activity of bergenin plays a role in the antinarcotic effects through adapting to morphine-induced oxidative stress in the brain. The naloxone-precipitated withdrawal symptom (jumping frequency) was significantly ameliorated (50% of control group) by administration of bergenin (20 mg/kg) in morphine-treated mice. Furthermore, morphine-induced down-regulation of glutathione (GSH) contents was reversed by bergenin administration in the frontal cortex and liver. Bergenin had no effects on the increased levels of nfr2-dependent antioxidant enzyme HO1 and NQO1 in the frontal cortex, striatum, and liver of morphine-treated mice. However, the morphine-induced increase in nrf2 nuclear translocation in the frontal cortex and striatum was inhibited by bergenin treatment. These results suggest that bergenin has a potential antinarcotic effect via regulation of GSH contents and oxidative stress.

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Hydrogen-rich saline attenuates anxiety-like behaviors in morphine-withdrawn mice

et al. 2017

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Morphine or its withdrawal affects plasma malondialdehyde, vitamin E levels and absence or presence of abstinence signs in rats

Abstract: A connection seems to exist between altered peroxide status and withdrawal signs in abstinent animals.

Cited by 4 publications

References 32 publications

The diagnostic importance of the concentration balance of metabolites of catecholamines and serotonin in patients with heroin and amphetamine addiction and withdrawal syndrome

The diagnostic importance of the concentration balance of metabolites of catecholamines and serotonin in patients with heroin and amphetamine addiction and withdrawal syndrome

Bergenin decreases the morphine-induced physical dependence via antioxidative activity in mice

Hydrogen-rich saline attenuates anxiety-like behaviors in morphine-withdrawn mice

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