Hydrogen-rich saline attenuates anxiety-like behaviors in morphine-withdrawn mice

Wen, Di; Zhao, Peng; Hui, Rongji; Wang, Jian; Shen, Qianchao; Gong, Miao; Guo, Hongyan; Cong, Bin; Ma, Chunling

doi:10.1016/j.neuropharm.2017.03.029

Cited by 21 publications

(11 citation statements)

References 35 publications

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“…Increasing evidence shows that molecular hydrogen administration provides many neuroprotective effects in central nervous system related diseases, such as ischemia-reperfusion injury, cerebral infarction, neonatal brain damage, radiation-induced damage, traumatic brain injury, cognitive impairments and Parkinson’s disease (Ohta, 2015 ; Huang, 2016 ). Most recently, our group and other groups’ studies showed that molecular hydrogen exerts neuroprotective effects on stress or drug dependance-induced memory impairment, depressive- and anxiety-like behaviors in mice, which are related to its efficient anti-oxidative, anti-inflammatory and anti-apoptotic activities (Ohno et al, 2012 ; Gao et al, 2017 ; Wen et al, 2017 ).…”

Section: Discussionmentioning

confidence: 98%

“…Molecular hydrogen can readily permeate through biomembranes such as the blood-brain barrier, blood-testis barrier and placental barrier, thus benefiting hard-to-reach organs (e.g., brain) and organelles due to its low molecular mass, non-ionic state and hydrophobic properties. An increasing number of studies report that molecular hydrogen offers important neuroprotective benefits in depression, anxiety, neuropathic pain, Parkinson’s disease, cognitive impairment and brain injury via attenuating excessive inflammatory response and oxidative stress (Imai et al, 2016 ; Zhang et al, 2016 ; Gao et al, 2017 ; Iketani and Ohsawa, 2017 ; Wen et al, 2017 ). In mice, HRW consumption ad libitum prevented cognitive impairment with an associated suppression of the markers of oxidative stress, malondialdehyde and 4-hydroxy-2-nonenal, and reversed the suppression on neural proliferation of the hippocampus caused by chronic physical restraint (Nagata et al, 2009 ).…”

Section: Introductionmentioning

confidence: 99%

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Hydrogen-Rich Water Ameliorates Autistic-Like Behavioral Abnormalities in Valproic Acid-Treated Adolescent Mice Offspring

Guo

Yin

Qiao

et al. 2018

Front. Behav. Neurosci.

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Due to its anti-inflammatory and anti-oxidative effects, recent research has demonstrated that molecular hydrogen can serve as a new medical approach for depression, anxiety and traumatic brain injury. However, its potential effects on neurodevelopmental diseases, such as autism are still elusive. The present study aims to investigate the potential effects of hydrogen-rich water (HRW) administration on valproic acid (VPA)-induced autistic-like behavioral deficits, and the associated underlying mechanism in adolescent mice offspring. Pregnant ICR mice were randomly divided into five groups (n = 6). One group was injected with saline (NAV group) and provided hydrogen-free water. The other four groups were injected with VPA (600 mg/kg, intraperitoneally, i.p.) on pregnant day (PND) 12.5. One group was provided with hydrogen-free water (VEH group) and the other three groups were provided HRW at different segments, postnatal day 1 (PND 1) to PND 21 (PHV group), PND 13 to PND 21 (PVS group) or from PND 13 to postnatal day 42 (PVL group). Behavioral tests, including open field, novelty suppressed feeding (NSF), hot plate, social interaction (SI) and contextual fear memory tests were conducted between postnatal day 35–42. We found that HRW administration significantly reversed the autistic-like behaviors induced by maternal VPA exposure in the adolescent offspring of both male and female adolescent offspring. Furthermore, HRW administration significantly reversed the alternation of serum levels of interleukin 6 (IL-6) and tumor necrosis factor-α (TNF-α), but without any effects on the BDNF levels in maternal VPA-exposed mice offspring. These data suggest the need for additional research on HRW as a potential preventive strategy for autism and related disorders.Lay Summary: Maternal VPA injection induces autistic-like behavioral deficits in adolescent mice offspring. HRW administration ameliorates autistic-like behavioral deficits. HRW administration reverses the alternation of serum levels of IL-6 and TNF-α induced by VPA.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Hydrogen-Rich Water Ameliorates Autistic-Like Behavioral Abnormalities in Valproic Acid-Treated Adolescent Mice Offspring

Guo

Yin

Qiao

et al. 2018

Front. Behav. Neurosci.

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“…In fact, HRS significantly reduces body weight loss, jumping behavior and wet-dog shakes in mice undergoing naloxone-precipitated withdrawal, and attenuates anxiety-like behaviors in the elevated plus-maze and light/dark box tests after naloxone-precipitated withdrawal or a 2-day spontaneous withdrawal period. 75 A recent study suggested that HRW may also be helpful in alleviating depressive-like behavior by suppressing inflammasome activation, and reducing the production of interleukin-1β and ROS, which was the first report that hydrogen exerts its therapeutic effect on depressive disorder. 76 …”

Section: T He R Esearch P mentioning

confidence: 99%

The transfer of hydrogen from inert gas to therapeutic gas

Shen

et al. 2017

Med Gas Res

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Hydrogen is the most abundant chemical element in the universe, and has been used as an inert gas for a long time. More recent studies have shown that molecular hydrogen as a kind of antioxidant, anti-inflammatory, anti-apoptosis, gene expression and signal modulation molecule, can be used for the treatment of many diseases. This review mainly focuses on the research progresses of hydrogen in various medical fields and the possible action mechanisms.

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“…Several studies have demonstrated the protective effects of molecular hydrogen in various CNS disease animal models, such as stroke, traumatic brain injury, Alzheimer’s disease, and Parkinson’s disease (Fu et al, 2009; Dohi et al, 2014; Ono et al, 2017; Nishimaki et al, 2018). Our previous study found that hydrogen-rich saline (HRS) injections significantly attenuated naloxone-precipitated morphine withdrawal symptoms and morphine withdrawal-induced anxiety-like behaviors as well as elevated corticosterone levels (Wen et al, 2017). A recent study also showed that consumption of hydrogen-rich water (HRW) prevented stress-induced impairments in learning tasks during chronic physical restraint by buffering the effect of oxidative stress (Nagata et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Effects of Molecular Hydrogen on Methamphetamine-Induced Neurotoxicity and Spatial Memory Impairment

et al. 2019

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Methamphetamine (METH) is a highly addictive stimulant, and METH exposure can induce irreversible neuronal damage and cause neuropsychiatric and cognitive disorders. The ever-increasing levels of METH abuse worldwide have necessitated the identification of effective intervention strategies to protect the brain against METH-induced neurotoxicity. The protective effects of molecular hydrogen on oxidative stress and related neurodegenerative diseases have been recently elucidated. Herein, we investigated whether treatment with molecular hydrogen ameliorated the METH-induced neurotoxicity and spatial learning and memory impairments. Male C57BL/6 mice received four intraperitoneal METH injections (10 mg/kg, 3-h interval), and stereotypic behaviors and hyperthermia were observed. After METH treatment and behavioral observation, the mice were returned to their home cages, where they received water or hydrogen-rich water (HRW) ad libitum for 7 days. We found that the molecular hydrogen delivered by ad libitum HRW consumption significantly inhibited the METH-induced spatial learning impairment and memory loss evidenced in the Barnes maze and Morris water maze tests. Furthermore, molecular hydrogen significantly restrained the neuronal damage in the hippocampus after high-dose METH exposure. Ad libitum HRW consumption also had an inhibitory effect on the METH-induced increase in the expression of Bax/Bcl-2, cleaved caspase-3, glucose-related protein 78 (GRP 78), CCAAT/enhancer-binding protein homologous protein (CHOP), and p-NF-kB p65 expression and elevation of interleukin (IL)-6 and tumor necrosis factor (TNF)-α levels in the hippocampus. These are the first findings to indicate that hydrogen might ameliorate METH-induced neurotoxicity and has a potential application in reducing the risk of neurodegeneration frequently observed in METH abusers.

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Hydrogen-rich saline attenuates anxiety-like behaviors in morphine-withdrawn mice

Cited by 21 publications

References 35 publications

Hydrogen-Rich Water Ameliorates Autistic-Like Behavioral Abnormalities in Valproic Acid-Treated Adolescent Mice Offspring

Hydrogen-Rich Water Ameliorates Autistic-Like Behavioral Abnormalities in Valproic Acid-Treated Adolescent Mice Offspring

The transfer of hydrogen from inert gas to therapeutic gas

Effects of Molecular Hydrogen on Methamphetamine-Induced Neurotoxicity and Spatial Memory Impairment

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