Morphine Anesthesia Blocks Cortisol and Growth Hormone Response to Surgical Stress in Humans

George, Jane; Reier, Charles E.; Lanese, Richard R.; Rower, J. Marvin

doi:10.1097/00132586-197508000-00016

Cited by 23 publications

(28 citation statements)

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“…The inconstant association between plasma cortisol and pain is, of course, consistent with the many observations that somatic "stress" in the absence of pain may cause marked increases in plasma cortisol, notably in anaesthetised patients undergoing surgery (Charters et al, 1969;George et al, 1974).…”

Section: Discussionsupporting

confidence: 82%

Circadian rhythms of plasma cortisol in migraine.

Ziegler¹,

Hassanein²,

Kodanaz³

et al. 1979

Journal of Neurology, Neurosurgery & Psychiatry

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Section: Discussionsupporting

confidence: 82%

Circadian rhythms of plasma cortisol in migraine.

Ziegler¹,

Hassanein²,

Kodanaz³

et al. 1979

Journal of Neurology, Neurosurgery & Psychiatry

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“…1996). The high number of supplementary morphine doses administered to group C (four of six dogs) within 3 hours after surgery in our study could have had a dampening effect on the adrenal response in this group (George et al. 1974).…”

Section: Discussionmentioning

confidence: 84%

The effects of preoperative extradural bupivacaine and morphine on the stress response in dogs undergoing femoro-tibial joint surgery

Sibanda

Hughes

Pawson

et al. 2006

Veterinary Anaesthesia and Analgesia

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“…1 Neuraxial opioids may reduce hormonal and adrenergic responses to stress. 2,3 A positive correlation between plasma concentrations of catecholamines and other stress responding hormones (e.g. cortisol) and the depth of anesthesia employing intravenous opioids as a component of the anesthetic mix has been demonstrated.…”

Section: Brief Reportsmentioning

confidence: 99%

Does intrathecal morphine alter the stress response following coronary artery bypass grafting surgery?

Hall

Adderley

Maclaren

et al. 2000

Can J Anesth/J Can Anesth

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463CAN J ANESTH 2000 / 47: 5 / pp [463][464][465][466] Purpose: Intrathecal morphine administered prior to coronary artery revascularization (CABG) surgery was studied to determine its effects on the stress response.Methods: In a single centre, open, randomized clinical trial, first time elective CABG surgery patients, < 75 yr, were studied. Control subjects (n=12) received a standardized anesthetic consisting of fentanyl (maximum cumulative dose of 35 µg·kg -1 ), propofol, and pancuronium. In addition, spinal subjects (n=13) received 1.0 mg (age > 60 yr) or 1.5 mg (age # 59 yr) intrathecal morphine prior to induction of anesthesia. Control subjects received continuous iv morphine at 2 mg·hr -1 on arrival in the ICU with iv bolus morphine supplementation as required while spinal subjects received bolus iv morphine as required. Changes in plasma cortisol and catecholamine concentrations were measured preoperatively, poststernotomy, on admission to ICU, following tracheal extubation, at 0800 hr on the first postoperative day, and 24 and 48 hr after ICU admission.

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Morphine Anesthesia Blocks Cortisol and Growth Hormone Response to Surgical Stress in Humans

Cited by 23 publications

References 0 publications

Circadian rhythms of plasma cortisol in migraine.

Circadian rhythms of plasma cortisol in migraine.

The effects of preoperative extradural bupivacaine and morphine on the stress response in dogs undergoing femoro-tibial joint surgery

Does intrathecal morphine alter the stress response following coronary artery bypass grafting surgery?

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