Morning versus evening induction of labour for improving outcomes

Goes, B.Y. van der; Pel, Maria; Mol, Ben Willem J.; Post, Joris A. M. van der

doi:10.1002/14651858.cd007707.pub2

Cited by 22 publications

(13 citation statements)

References 36 publications

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“…While there were no differences in whether or not birth occurred within 24 h of induction or whether or not a cesarean delivery was used, morning inductions required less oxytocin, had a shorter induction to birth interval, and were less likely to result in instrumental vaginal births for women in their first pregnancies (79). However, it is important to note that a recent meta-analysis of perinatal mortality found no overall difference between morning and evening prostaglandin application or oxytocin-delivery in either maternal or neonatal outcomes (80). The day/night profile of melatonin secretion is one putative underlying mechanism for time-of-day differences in labor and delivery or in the success rate of labor intervention.…”

Section: Circadian Regulation Of Parturitionmentioning

confidence: 99%

Shift Work and Circadian Dysregulation of Reproduction

Gamble¹,

Resuehr²,

Johnson³

2013

Front. Endocrinol.

118

104

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Health impairments, including reproductive issues, are associated with working nights or rotating shifts. For example, shift work has been associated with an increased risk of irregular menstrual cycles, endometriosis, infertility, miscarriage, low birth weight or pre-term delivery, and reduced incidence of breastfeeding. Based on what is known about circadian regulation of endocrine rhythms in rodents (and much less in humans), the circadian clock is an integral regulatory part of the reproductive system. When this 24-h program is disordered by environmental perturbation (such as shift work) or genetic alterations, the endocrine system can be impaired. The purpose of this review is to explore the hypothesis that misalignment of reproductive hormones with the environmental light-dark cycle and/or sleep-wake rhythms can disrupt menstrual cycles, pregnancy, and parturition. We highlight the role of the circadian clock in regulating human reproductive physiology and shift work-induced pathology within each step of the reproductive axis while exploring potential mechanisms from the animal model literature. In addition to documenting the reproductive hazards of shift work, we also point out important gaps in our knowledge as critical areas for future investigation. For example, future studies should examine whether forced desynchronization disrupts gonadotropin secretion rhythms and whether there are sleep/wake schedules that are better or worse for the adaptation of the reproductive system to shift work. These studies are necessary in order to define not only whether or not shift work-induced circadian misalignment impairs reproductive capacity, but also to identify strategies for the future that can minimize this desynchronization.

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Section: Circadian Regulation Of Parturitionmentioning

confidence: 99%

Shift Work and Circadian Dysregulation of Reproduction

Gamble¹,

Resuehr²,

Johnson³

2013

Front. Endocrinol.

118

104

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show abstract

“…One European study identified number of vaginal examinations as a specific concern. 57 Side effects of prostaglandins include gastrointestinal (diarrhea, nausea, and vomiting) and fever/chills but are uncommonoccurring in 1% to 8% of women depending on the dose and route of administration. One trial comparing oral and vaginal misoprostol reported on patient satisfaction; rates of satisfaction were not different, however, the rate of patient dissatisfaction in both the arms was very low at 1%.…”

Section: Patient Satisfactionmentioning

confidence: 99%

Methods of Cervical Ripening and Labor Induction

Goetzl

2014

Clinical Obstetrics &Amp; Gynecology

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Over the years, multiple forms and doses of pharmacologic agents have been used for cervical ripening and labor induction. This chapter will review potential criteria and article situations for choosing a particular pharmacologic agent. The discussion in this chapter will be limited to comparisons between pharmacologic agents; direct comparisons between mechanical agents and pharmacologic agents will largely be reviewed in the accompanying article: Methods of cervical ripening and labor induction: mechanical. For the purposes of this discussion, the term labor induction will be limited to patients with a "favorable cervix" by Bishop's score <6, whereas the term cervical ripening will be limited to patients with an unfavorable cervix and includes subsequent induction or augmentation of labor. Although the pharmacologic agent used for the initial cervical ripening process is the focus of this discussion, subsequent treatment with oxytocin may or may not be required for delivery.

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“…Induction of labour is the process of arti cially stimulating uterine contractions to initiate the onset of labour. Approximately one in four pregnancies in the developed world will end with an induction of labour [1,2] Current international guidelines note that induction of labour, as with any intervention, carries risks and recommend it be performed only when there are clear indications that continuing with the pregnancy is of greater risk to the mother or fetus than the risk of induction of labour [3,2,4]. However conversely, recent studies have reported that elective pharmacological induction of labour results in a lower risk of caesarean section than expectant management [5,6,7].…”

Section: Introductionmentioning

confidence: 99%

Feasibility study protocol of a pragmatic, randomised controlled pilot trial: Membrane sweeping to prevent post-term pregnancy: The MILO Study

Finucane

Murphy

Cotter

et al. 2020

Preprint

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BackgroundPost-term pregnancy is associated with an increased risk of maternal complications, respiratory distress and trauma to the neonate. Amniotic membrane sweeping has been recommended as a simple procedure to promote the spontaneous onset of labour. However, despite its widespread use, there is an absence of evidence on a) its effectiveness and b) its optimal timing and frequency. The primary aim of the MILO study is to inform the optimal design of a future definitive randomised trial to evaluate the effectiveness (including optimal timing and frequency) of membrane sweeping to prevent post-term pregnancy. We will also assess the acceptability and feasibility of the proposed trial interventions to clinicians and women (through focus group interviews).Methods/DesignMulticentre, pragmatic, parallel group, pilot randomised controlled trial with an embedded factorial design. Pregnant women with a live, singleton fetus ≥ 38 weeks gestation, cephalic presentation, longitudinal lie, intact membranes, English speaking and ≥18 years of age will be randomised in a 2:1 ratio to:- Membrane sweep versus no membrane sweepWomen allocated randomly to a sweep will then be randomised further (factorial component) to:- early (from 39 weeks) versus late (from 40 weeks) sweep commencement; and- a single verses weekly sweepThe proposed feasibility study consists of four work packages i.e., (1) a multicentre, pilot randomised trial, 2) a health economic analysis and 3) a qualitative study (4) a study within the host trial (a SWAT).Outcomes to be collected include: recruitment and retention rates, compliance with protocol, randomisation and allocation processes, attrition rates and cost-effectiveness.Focus groups will be held with women and clinicians to explore the acceptability and feasibility of the proposed intervention, study procedures and perceived barriers and enablers to recruitment.DiscussionThe primary aim of the MILO study is to inform the optimal design of a future definitive randomised trial to evaluate the effectiveness (including optimal timing and frequency) of membrane sweeping to prevent post-term pregnancy. Results will inform whether and how the design of the definitive trial as originally envisaged should be delivered or adapted.Trial RegistrationClinicalTrials.gov, ID: NCT04307199. Registered 12th March 2020. https://clinicaltrials.gov/ct2/show/NCT04307199?id=NCT04307199&draw=2&rank=1

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Morning versus evening induction of labour for improving outcomes

Cited by 22 publications

References 36 publications

Shift Work and Circadian Dysregulation of Reproduction

Shift Work and Circadian Dysregulation of Reproduction

Methods of Cervical Ripening and Labor Induction

Feasibility study protocol of a pragmatic, randomised controlled pilot trial: Membrane sweeping to prevent post-term pregnancy: The MILO Study

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