Methods of Cervical Ripening and Labor Induction

Goetzl, Laura

doi:10.1097/grf.0000000000000024

Cited by 13 publications

(9 citation statements)

References 38 publications

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“…Although pharmaceutical labor induction had largely replaced mechanical induction, the mechanical indication is not obselete. 23 To date, many institutions still use pharmaceutical only, mechanical only, or a combination of both for labor induction. The choice depends largely on local institutional preferences, practical experience, instrumental availability, financial status, and available resources.…”

Section: Pharmaceutical Versus Mechanical Induction Of Labormentioning

confidence: 99%

Pharmaceutical versus mechanical induction of labor

Alsaif

Helmy²,

Almuallem

et al. 2018

Int J Reprod Contracept Obstet Gynecol

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Labor induction is one of the most common obstetric interventions carried out in obstetric institutions. More than one fifth of labors needs induction. To date, many methods are available for labor induction with the pharmaceutical and mechanical methods being the commonest. The most common pharmaceutical agents used are prostaglandins, oxytocin, synthetic progesterone antagonists, and nitric oxide. Mechanical induction is carried out through using balloon catheters, hygroscopic dilators, artificial membrane rupture, or membrane stripping. Though pharmaceutical methods had largely replaced mechanical induction of labor, no consensus guidelines recommend their use. Studies from literature are still conflicting. However, it is generally agreed that the use of a combined approach with both pharmaceutical and mechanical methods of induction yields the best outcome. This article will review the different methods for labor induction, their effectiveness, and adverse events.

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Section: Pharmaceutical Versus Mechanical Induction Of Labormentioning

confidence: 99%

Pharmaceutical versus mechanical induction of labor

Alsaif

Helmy²,

Almuallem

et al. 2018

Int J Reprod Contracept Obstet Gynecol

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“…PGE 2 has multiple normal physiological functions, most importantly labor induction (Goetzl, ). Additionally, the lung is a privileged site for beneficial actions of PGE 2 (Vancheri et al , ).…”

Section: Lipid Mediators Involved In Inflammationmentioning

confidence: 99%

“…Specific inhibition of PGD synthase is another promising therapeutic approach, with multiple PGD synthase inhibitors being identified for the treatment of various inflammatory disorders (Edfeldt et al, 2015). PGE 2 has multiple normal physiological functions, most importantly labor induction (Goetzl, 2014). Additionally, the lung is a privileged site for beneficial actions of PGE 2 (Vancheri et al, 2004).…”

Section: Prostaglandinsmentioning

confidence: 99%

Regulation of inflammation by lipid mediators in oral diseases

Sommakia

Baker

2016

Oral Diseases

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Lipid mediators (LM) of inflammation are a class of compounds derived from ω-3 and ω-6 fatty acids that play a wide role in modulating inflammatory responses. Some LM possess pro-inflammatory properties, while others possess pro-resolving characteristics, and the class switch from pro-inflammatory to pro-resolving is crucial for tissue homeostasis. In this article, we review the major classes of LM, focusing on their biosynthesis and signaling pathways, and their role in systemic and, especially, oral health and disease. We discuss the detection of these LM in various body fluids, focusing on diagnostic and therapeutic applications. We also present data showing gender-related differences in salivary LM levels in healthy controls, leading to a hypothesis on the etiology of inflammatory diseases, particularly, Sjögren’s Syndrome. We conclude by enumerating open areas of research where further investigation of LM is likely to result in therapeutic and diagnostic advances.

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“…Two forms of PGE2 (Dinoprostone) are available commercially. [2][3][4] Cerviprime (In India), which is formulated as a gel (3gm gel/0.5mg Dinoprostone) is placed inside the cervix but not inside the internal os. Application can be repeated in 6 hours, not to exceed 3 doses in 24 hours.…”

Section: Introductionmentioning

confidence: 99%

Intracervical PGE2 gel application for cervical ripening and induction of labour: a clinical study

Modi¹,

Mahur²,

Shashank³

2019

Int J Reprod Contracept Obstet Gynecol

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Background: PGE2 gel (cerviprime) not only helps in cervical ripening but also sensitizes the uterine musculature to physiological PGE2 for generation and maintenance of uterine contractions. In the present study the efficacy of PGE2 intracerival gel for ripening and induction of labour has been reported.Methods: This is a randomized prospective study of 80 cases admitted to the labour room during period of 2 years i.e. March 2017 to March 2019 in Department of Obstetrics and Gynecology, KBNIMS, Gulbarga, Karnataka. All patients had clear indications for termination of pregnancy. The initial bishop score determined prior to induction by pelvic examination. Under aseptic precautions PGE2 endocervical gel was instilled. The results analyzed for successful ripening, induction delivery interval, results in primigravida and multigravida with single instillation or reinstallation if required, mode of delivery and maternal and perinatal complications.Results: The present study of 80 cases showed that a single application of intracervical PGE2 gel caused favorable changes in cervix by increasing Bishop score and shortened induction delivery interval with minimal side effects. Successful ripening with single application was achieved in 92.5% of cases (primi 42.5% and multi 50%). Only 6.25% of primi's and 1.25% of multi’s required reinstallation of PGE2 gel. Successful induction was achieved in 47.5% primi's and 50% multi’s i.e. 97.5% cases.Conclusions: The study concludes that single low dose intracervical PGE2 (cerviprime) gel proved to a safe, reliable and effective method for cervical ripening and induction of labour.

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Methods of Cervical Ripening and Labor Induction

Cited by 13 publications

References 38 publications

Pharmaceutical versus mechanical induction of labor

Pharmaceutical versus mechanical induction of labor

Regulation of inflammation by lipid mediators in oral diseases

Intracervical PGE2 gel application for cervical ripening and induction of labour: a clinical study

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