Regulation of inflammation by lipid mediators in oral diseases

Sommakia, Salah; Baker, Olga J.

doi:10.1111/odi.12544

Cited by 20 publications

(17 citation statements)

References 381 publications

(382 reference statements)

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“…Gingipains not only deal with cell surface proteins when contacted but also degrade components of the cell-to-cell contacts and cause detachment of epithelial cells from the connective tissue of the gingiva [44, 45]. Several kind of genes associated with the synthesis of fatty acids, such as fatty acid synthase, esterase and MaoC domain protein dehydratase, were found to be enriched in controls, and some kinds of fatty acids have been reported to be of benefit for oral health and play a positive role in periodontitis treatment [46, 47].…”

Section: Discussionmentioning

confidence: 99%

“…It is crucially important to maintain an effective barrier around the organism for active efflux systems, to reduce the influx of antimicrobials into the cell [41]. MaoC domain protein dehydratase, were found to be enriched in controls, and some kinds of fatty acids have been reported to be of benefit for oral health and play a positive role in periodontitis treatment [46,47].…”

Section: Several Args and All Virgs With Ka/ks > 1 In Periodontitis Wmentioning

confidence: 99%

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Metagenomic Analysis Reveals A Possible Association Between Respiratory Infection and Periodontitis

Liu

Zhang

et al. 2020

Preprint

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Periodontitis is an inflammatory disease which is characterized by progressive destruction of the periodontium and causes tooth loss in adults. Periodontitis is known to be associated with dysbiosis of the oral microflora, often linked to various diseases. However, the complexity of plaque microbial communities of periodontitis, and antibiotic resistance and enhanced virulence make this disease difficult to treat. Therefore, we used metagenomic shotgun sequencing in this study to investigate the etiology, antibiotic-resistant genes (ARGs) and virulence genes (VirGs) of periodontitis. We revealed a significant shift in the composition of oral microbiota as well as several functional pathways that were represented significantly more abundant in periodontitis patients than in controls. Additionally, we observed several positively selected ARGs and VirGs with the Ka/Ks ratio > 1 by analyzing our data and a previous periodontitis dataset, indicating that ARGs and VirGs in oral microbiota may suffer from positive selection. Moreover, 5 of 12 positively selected ARGs and VirGs in periodontitis patients were found in the genomes of respiratory tract pathogens. Of note, 91.8% of the background VirGs with at least one non-synonymous single-nucleotide polymorphism for natural selection were also from respiratory tract pathogens. These observations suggest a potential association between periodontitis and respiratory infection at the gene level. Our study enriches the knowledge of pathogens and functional pathways as well as the positive selection of antibiotic resistance and pathogen virulence in periodontitis patients, and provides evidence from the gene level for an association between periodontitis and respiratory infection.

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Section: Discussionmentioning

confidence: 99%

Section: Several Args and All Virgs With Ka/ks > 1 In Periodontitis Wmentioning

confidence: 99%

Metagenomic Analysis Reveals A Possible Association Between Respiratory Infection and Periodontitis

Liu

Zhang

et al. 2020

Preprint

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“…16 Specific to SS, exogenous resolvin administration has the potential to reduce inflammation and restore salivary gland function. 17 Naturally occurring resolvin subtypes include the D series (derived from docosahexaenoic acid), the E series (derived from eicosapentaenoic acid), and six analogs of the D series, which are produced in response to aspirin. 18 Previously, we identified resolvin D1 (RvD1) as a therapeutic candidate for the treatment of SS.…”

Section: Pbpk Analysis Of Rvd1mentioning

confidence: 99%

“…These pro‐resolving lipid mediators have been detected in animal models of infection and chronic inflammation 16 . Specific to SS, exogenous resolvin administration has the potential to reduce inflammation and restore salivary gland function 17 …”

mentioning

confidence: 99%

Predicting Resolvin D1 Pharmacokinetics in Humans with Physiologically‐Based Pharmacokinetic Modeling

Yellepeddi

Parashar

Dean

et al. 2020

Clinical Translational Sci

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Sjögren's syndrome (SS) is an autoimmune disease with no effective treatment options. Resolvin D1 (RvD1) belongs to a class of lipid-based specialized pro-resolving mediators that showed efficacy in preclinical models of SS. We developed a physiologically-based pharmacokinetic (PBPK) model of RvD1 in mice and optimized the model using plasma and salivary gland pharmacokinetic (PK) studies performed in NOD/ShiLtJ mice with SS-like features. The predictive performance of the PBPK model was also evaluated with two external datasets from the literature reporting RvD1 PKs. The PBPK model adequately captured the observed concentrations of RvD1 administered at different doses and in different species. The PKs of RvD1 in virtual humans were predicted using the verified PBPK model at various doses (0.01-10 mg/kg). The first-inhuman predictions of RvD1 will be useful for the clinical trial design and translation of RvD1 as an effective treatment strategy for SS.

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“…At the same time there is a cascade of neuro-regulatory, neuro-trophic, biochemical, immunological and functional disorders, microcirculatory and metabolic disorders. Disorders of almost all types of metabolism develop: protein, lipid, carbohydrate, mineral, which eventually leads to irreversible destruction of the periodontium and periodontium bones [8,9].…”

Section: Introductionmentioning

confidence: 99%

Intensity and duration of phases of wound healing after surgical intervention in сases of spontaneous periodontitis accompanied by various reactivity of the body

Yarov

2021

SR:MS

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The usage of the principle of optimal management, namely such effects on complicated forms, when the course of the disease is close to that of uncomplicated course of the disease is very promising in drug therapy of patients with generalized periodontitis. The aim is to study the intensity and duration of the phases of wound healing of the mucosa after spontaneous periodontitis surgery accompanied by normo-, hyper- and hyporeactivity of the body by cytological examination of smear-imprints of wound exudate. Materials and methods: The experiments were performed on 24 adult mongrel dogs divided into three equal groups. In the first group, drugs that disrupt the reactivity of the organism were not used (normoreactivity of the organism). In the second group, the animals were simulated a сondition of hyperreactivity, in the third group – the hyporeactivity of the organism. All the animals with spontaneous periodontitis underwent a patchwork surgery. In the period after surgery, cytological examination was performed on the 1st, 4th, 6th and 9th day of the experiment. Results: It has been revealed that in cases of the normal reactivity of the organism the following periods of cellular reactions during the healing of the gums mucous membrane can be differentiated within the appropriate terms: the period of degenerative-inflammatory changes (1st day), active granulocyte-macrophage reaction (4th day), reparations (6th day) and the period of increase of reparative processes with a decrease in the overall cellular response (9th day). Examination of smear-imprints after surgical treatment in animals with spontaneous periodontitis with hyper- and hyporeactivity of the body allowed to identify the same periods of cellular reactions during the healing of the gingival mucosa, as in cases of normoreaction with hyperreation.Tthe intensity and duration of the wound healing phases differed from those which are typical for normoreactivity of the body: granulocyte-macrophage reaction was more pronounced and lasted longer until the 6th day, so later only on the 9th day there were cellular signs of regeneration. With hyporeaction, the intensity and duration of the wound healing phases differed from those which are typical for normoreactivity of the body: granulocyte reaction occurred later (only on the 6th day) and lasted longer, signs of active regeneration appeared later on the 9th day. Therefore, postoperative wound healing in animals with impaired body reactivity was delayed for 3-4 days. Conclusions: Thus, direct medical correction with transforming intensity and duration of the phases of the wound process which are characteristic for impaired reactivity of the body into the phases which are typical for normoreaction is essential. It provides synchronization of necrotic and reparative processes and creates conditions for normal uncomplicated healing of periodontal soft tissues

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Regulation of inflammation by lipid mediators in oral diseases

Cited by 20 publications

References 381 publications

Metagenomic Analysis Reveals A Possible Association Between Respiratory Infection and Periodontitis

Metagenomic Analysis Reveals A Possible Association Between Respiratory Infection and Periodontitis

Predicting Resolvin D1 Pharmacokinetics in Humans with Physiologically‐Based Pharmacokinetic Modeling

Intensity and duration of phases of wound healing after surgical intervention in сases of spontaneous periodontitis accompanied by various reactivity of the body

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