Morning levels of fibrinogen in children with sleep-disordered breathing

Abstract

Elevated fibrinogen level is a predictor of cardiovascular disease in adults, and it is associated with sleep-disordered breathing. Levels of fibrinogen in adults are affected by other co-existing cardiovascular risk factors, which are not usually present in children.To investigate the association between fibrinogen and sleep-disordered breathing, a case-control study was carried out in children with and without habitual snoring. All snoring children underwent polysomnography.Morning fibrinogen values in 30 children with snoring and an apnoea-hypopnoea index (AHI) o5 episodes?h -1 (median (interquartile range) 318 mg?dL -1 (290-374)) were similar to values in 61 children with snoring and an AHI v5 episodes?h -1 (307 (269-346)). Both groups had higher fibrinogen values than those in 23 controls without snoring (271 mg?dL -1 (244-294)). There was no correlation between fibrinogen values and AHI, respiratory movement/arousal index or haemoglobin desaturation index.In conclusion, fibrinogen values are higher in children with snoring than in controls, but there is no association between these values and polysomnography indices.

Sleep Apnea and Cardiovascular Disease

“…P-selectin, C-reactive protein, fibrinogen, interleukin-8, and interferon-␥ levels were found to be higher in children with snoring and/or OSA compared with control subjects. [387][388][389][390][391] In a study of 143 adolescents, mean C-reactive protein level demonstrated a dose-response increase with SDB that was independent of BMI and partially explained by the severity of nocturnal hypoxemia. 91 Whether these mediators predict cardiovascular risk in children and adolescents has yet to be demonstrated.…”

Myeloid-related protein 8/14 levels in children with obstructive sleep apnoea

“…processes, may underlie such changes along with increasing the adherence of inflammatory mediators to endothelial cells and hypercoagulability [1,5,8,19,30,[39][40][41][42]. Hyperactivation and increased reactivity of the sympathetic system have been reported in children with OSA [43][44][45] and systemic blood pressure elevations are not only OSA-severity dependent [46][47][48], but are also associated with altered left ventricular geometry and contractibility [49].…”

Obstructive sleep apnea and cardiovascular risk in children

“…Выявлено также, что у больных детей отмечается повышение плазменного уровня миелоидсвязанно-го белка 8/14 (MRP 8/14) -биомаркера воспаления сосудов, играющего важную роль в атеросклероти-ческом поражении сосудов [56]. Риск поражения со-судов усугубляется и повышением коагуляционного потенциала сыворотки на фоне обструктивных нару-шений дыхания во время сна у детей [57].…”