Moringa oleifera-Rich Diet and T Cell Calcium Signaling in Spontaneously Hypertensive Rats

Attakpa, Eugène; Bertin, G.; Chabi, Nicodème W.; Ategbo, J-M; Seri, Bialli; Khan, Naim Akhtar

doi:10.33549/physiolres.933397

Cited by 12 publications

(15 citation statements)

References 60 publications

(42 reference statements)

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“…One study reported that MO had no effects on blood pressure, 28 but another study demonstrated an antihypertensive effect of MO, which was explained by the inhibition of IL-2 secretion and modulation of T-cell calcium signaling, an effect that was not observed in normotensive rats. 29 Thus, in the present study, although the rats had higher blood pressure after consuming the high-fat/fructose diet, they were not notably hypertensive, which may explain the lack of effectiveness of MO treatment on blood pressure.…”

Section: Discussioncontrasting

confidence: 46%

Effects of Moringa oleifera leaf powder on metabolic syndrome induced in male Wistar rats: a preliminary study

et al. 2018

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ObjectiveTo evaluate the preventive effects of Moringa oleifera on metabolic syndrome (MS) in male Wistar rats.MethodsMS was induced by feeding rats a high-fat diet and drinking water containing 10% fructose for 6 weeks. In the preventive group, M. oleifera was orally administered for 3 weeks prior to the induction of MS, while in the treatment group, M. oleifera was administered for 3 weeks after the onset of MS. The treatment groups were compared with a control group of untreated rats with induced MS. Fasting glucose, oral glucose tolerance, insulin tolerance, total cholesterol, triglycerides, abdominal circumference, and systolic and diastolic blood pressure were measured before and after MS induction and/or M. oleifera treatment.ResultsAfter the induction of MS, the control group had higher fasting glucose levels than the preventive group. No significant differences were observed in insulin tolerance, oral glucose tolerance, cholesterol, triglycerides, abdominal circumference, or systolic or diastolic blood pressure. Compared with untreated controls, rats in the treatment group had significantly improved glucose tolerance, triglycerides, and abdominal circumference.ConclusionsM. oleifera treatment attenuates MS in Wistar rats.

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Section: Discussioncontrasting

confidence: 46%

Effects of Moringa oleifera leaf powder on metabolic syndrome induced in male Wistar rats: a preliminary study

et al. 2018

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“…Attakpa et al Showed that administration of Moringa oleifera in mice will increase intracellular calcium ion levels in lymphocyte cells and will cause the death of lymphocyte cells by apoptosis. 6 Large increases in free Ca2 + in intracellular space are very toxic 7 , which results in:…”

Section: Discussionmentioning

confidence: 99%

“…5 Moringa oleifera has two mechanisms for inhibiting Lupus. Moringa has immunosupressant properties by decreasing the number of CD4 T cells (T Helper cells) 6 with cell apoptosis pathways due to excessive calcium influx in cells (Zainal Path) 7 . In addition Moringa oleifera will have an anti-inflammatory effect by inhibiting nfĶβ 8 .…”

Section: Introductionmentioning

confidence: 99%

The effect of Mmoringaoleifera leaf extract on mean platelet volume and neutrophil to lymphocyte ratio in lupus

Widyastuti

Prabowo

Adnan

et al. 2021

Bangladesh J Med Sci

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Introduction: No definitive treatment is available for Lupus. Moringaoleiferais one of promisingnovel treatments in Lupus trough anti inflammation and immunosupresion. Mean platelet volume andneutrophil to lymphocyte ratio used to measure degree of lupus activities. Objective: Our study wasaimed to identify the effect of Moringaoleiferaextract on the Mean platelet volume and neutrophil to lymphocyte ratio in lupus. Methods: This experimental study was conducted in 30 lupus patients,located in the rheumatology clinic at Moewardi General Hospital in January-March 2019. The studygroup was divided into two groups: the treatment research group received 2 grams of moringa extractper day and the placebo group. The study was conducted for 4 weeks and was evaluated when thestudy was completed. MPV and NLR examination using a hemocytometer. Statistical analysis wasperformed using paired T test, independent T-test. The p value was considered significant when the p < 0.05. Results: The results showed a decrease in MPV (delta MPV = 4.141; r 0.656; p-0.02) anda decrease in Neurophil to lymfocyte ratio (delta NLR = 4.1391; r 0.489; p-0.04) Conclusion: Thestudy demonstrated the effect of Moringaoleiferaleaf extract on reduced Mean platelet volume andneutrophil to lymphocyte ratio in lupus Bangladesh Journal of Medical Science Vol.20(1) 2021 p.68-73

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“…The antihypertensive effect of MO leaves had been shown in previous review [ 2 ]. Recent animal studies [ 25 ] have shown that MO leaf exerts antihypertensive effects by inhibiting the secretion of IL-2 and modulates T-cell calcium signaling in hypertensive rats. Therefore, further study of blood pressure lowering effect of Moringa oleifera is needed.…”

Section: Discussionmentioning

confidence: 99%

Effect of Moringa oleifera Leaf Capsules on Glycemic Control in Therapy‐Naïve Type 2 Diabetes Patients: A Randomized Placebo Controlled Study

Taweerutchana

Lumlerdkij

Vannasaeng

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Background Studies showed effects of Moringa oleifera (MO) on lowering blood sugar levels in animal and diabetes patients. The aims of this study were to determine the effect of MO leaf capsules on glucose control in therapy-naïve type 2 diabetes mellitus (T2DM) and to evaluate its safety. Method This was a prospective randomized placebo controlled study. Therapy-naïve T2DM was randomly assigned to receive either 8 grams per day of MO leaf capsules (MO leaf group) or placebo for 4 weeks. Clinical and laboratory characteristics were recorded at screening and at the end of 4-week study. 9-point plasma glucose was obtained before and every week during the study. Results Thirty-two T2DM patients were enrolled. The mean age was 55 years and the mean HbA1C was 7.0%. There was no significant difference in FPG and HbA1C between groups. MO leaf group had SBP reduction by 5 mmHg as compared to baseline but this difference had no statistical significance. There were no adverse effects of MO leaf. Conclusions Moringa oleifera leaf had no effect on glycemic control and no adverse effects in T2DM. Interestingly, this study demonstrated that MO leaf had a tendency on blood pressure reduction in T2DM, and this result needs further investigation.

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Moringa oleifera-Rich Diet and T Cell Calcium Signaling in Spontaneously Hypertensive Rats

Cited by 12 publications

References 60 publications

Effects of Moringa oleifera leaf powder on metabolic syndrome induced in male Wistar rats: a preliminary study

Effects of Moringa oleifera leaf powder on metabolic syndrome induced in male Wistar rats: a preliminary study

The effect of Mmoringaoleifera leaf extract on mean platelet volume and neutrophil to lymphocyte ratio in lupus

Effect of Moringa oleifera Leaf Capsules on Glycemic Control in Therapy‐Naïve Type 2 Diabetes Patients: A Randomized Placebo Controlled Study

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