The effect of Mmoringaoleifera leaf extract on mean platelet volume and neutrophil to lymphocyte ratio in lupus

Abstract

Introduction: No definitive treatment is available for Lupus. Moringaoleiferais one of promisingnovel treatments in Lupus trough anti inflammation and immunosupresion. Mean platelet volume andneutrophil to lymphocyte ratio used to measure degree of lupus activities.
 Objective: Our study wasaimed to identify the effect of Moringaoleiferaextract on the Mean platelet volume and neutrophil to lymphocyte ratio in lupus.
 Methods: This experimental study was conducted in 30 lupus patients,located in the rheumatology clinic at Moewardi General Hospital in January-March 2019. The studygroup was divided into two groups: the treatment research group received 2 grams of moringa extractper day and the placebo group. The study was conducted for 4 weeks and was evaluated when thestudy was completed. MPV and NLR examination using a hemocytometer. Statistical analysis wasperformed using paired T test, independent T-test. The p value was considered significant when the p < 0.05.
 Results: The results showed a decrease in MPV (delta MPV = 4.141; r 0.656; p-0.02) anda decrease in Neurophil to lymfocyte ratio (delta NLR = 4.1391; r 0.489; p-0.04)
 Conclusion: Thestudy demonstrated the effect of Moringaoleiferaleaf extract on reduced Mean platelet volume andneutrophil to lymphocyte ratio in lupus
 Bangladesh Journal of Medical Science Vol.20(1) 2021 p.68-73

Moringa Oleifera Extract Decreases Interleukin 6 Levels and Disease Activity in Rheumatoid Arthritis Patients

“…Many studies have shown that M. oleifera stops NO, VEGF, TNF, IL-2, IL-1ß, IL6, glucose-6-phosphatase, insulin, leptin, resistin, and cholesterol from doing their jobs. The most common pathway, which is thought to be the prototypical proinflammatory signaling pathway, and the parent transcription factor (13) .…”

“…This is shown by the fact that when high doses of Moringa leaf extract were given, the number of CD4+ T cells went up less than when low doses were given. The most important effect of high doses of SLE is that they cause immunosuppression by killing lymphocytes (13) .…”

“…In addition, Moringa oleifera will have an anti-inflammatory effect by inhibiting NF. Inhibition of nf will cause a decrease in proinflammatory cytokines IL 6, IL 1, and TNF, so tissue inflammation decreases (13) . Moringa oleifera leaf extract has shown anti-inflammatory, anti-arthritis, and immunosuppressant effects in mice with RA (14)(15)(16) .…”

The Effect of Snail Mucus (Achatina Fulica) Toward The Activity and Chronicity Indices of Renal Histology in Pristane-Induced Lupus Nephritis Mice Model

“…Systemic lupus erythematosus (SLE) is a common autoimmune rheumatic disease with a complex mechanism and pathogenesis [1][2][3][4][5] . SLE can affect the kidney, resulting in nephritis due to the presence of the immune complex in the glomerular basement membrane (GBM) 3,6,7 .…”

Moringa Oleifera Extract Decreases Interleukin 6 Levels and Disease Activity in Rheumatoid Arthritis Patients

“…In addition, Moringa oleifera will have an antiinflammatory effect by inhibiting NF. Inhibition of nf will cause a decrease in proinflammatory cytokines IL 6, IL 1, and TNF, so tissue inflammation decreases (13) . Moringa oleifera leaf extract has shown anti-inflammatory, anti-arthritis, and immunosuppressant effects in mice with RA (14)(15)(16) .…”