Morinda officinalis How. – A comprehensive review of traditional uses, phytochemistry and pharmacology

Zhang, Jianhua; Xin, Hailiang; Xu, Yong; Shen, Yi; He, Yiqing; Hsien-Yeh,; Lin, Bangjiang; Hong-tao, Song; Juan-Liu,; Yang, Hai-Yue; Qin, Lu‐Ping; Zhang, Qiaoyan; Du, Jianxiu

doi:10.1016/j.jep.2017.10.028

Cited by 142 publications

(109 citation statements)

References 29 publications

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“…The fruits, seeds, young leaves, flowers, roots and bark of M. citrifolia are used in prevention of rheumatic pain, inflammation, head colds, neuralgia, cough, internal bleeding, liver diseases, ulcers and gout, intestinal worms and menstrual cramps (Heinicke, ; Mckoy, Everton, & Oswald, ). The fruit juice is used to treat diabetes, hypertension and arteriosclerosis (Toungken et al, ), impotence, osteoporosis and depression (Zhang et al, ; Li et al, ; Potterat & Hamburger, ; Pawlus & Kinghorn, ; Table ). M. officinalis is widely distributed in subtropical and tropical districts of north‐eastern parts of India (Tao & Taylor, ; Zhang, Chen, & Lin, ).…”

Section: Botany and Ethnomedicinal Uses Of Indian Morinda Speciesmentioning

confidence: 99%

Indian Morinda species: A review

Singh

Sharma

2019

Phytotherapy Research

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Morinda is a largest genus of Rubiaceae family, and its 11 species are found in India.In India, plant species are known by several common names as great morinda, Indian mulberry, noni, beach mulberry and cheese fruit. Various Morinda products (capsules, tablets, skin products and fruit juices) are available in the market, used by people for treatment of several health complaints. A diversity of phytochemicals including iridoids, flavonoids, flavonoid glycosides, anthraquinones, coumarins, lignanas, noniosides, phenolics and triterpenoids have been reported from Morinda species. Morinda species are used in the treatment of inflammation, cancer, diabetes, psyquiatric disorders, and bacterial and viral infections. The noni fruit juice (Morinda citrifolia) and its products are used clinically in the treatment of cancer, hypertension and cervical spondylosis affecting patients. M. citrifolia fuit juice, with different doses, is used in the maintaining blood pressure and reducing of superoxides, HDL and LDL levels. Similarly, oligosaccharide capsules and tablets of root extract of M. officinalis are recommended as medicine for the treatment of kidney problems and sexual dysfunctions of patients. The toxicological studies revealed that higher doses of fruit juice (4,000 or 5,000 mg/kg) of M. citrifolia for 2 or more months cause toxic effects on liver and kidneys. M. officinalis root extracts (ethanolic and aqueous) are found fully safe during treatment of diseases. A large number of reviews are available on M. citrifolia but very few studies are conducted on other Indian Morinda species. This review reports the comprehensive knowledge on state-wise distribution, botany, ethnomedicinal uses, phytochemistry, pharmacological activities, clinical applications and toxicological evaluations of 11 species of Morinda found in India.

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Section: Botany and Ethnomedicinal Uses Of Indian Morinda Speciesmentioning

confidence: 99%

Indian Morinda species: A review

Singh

Sharma

2019

Phytotherapy Research

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“…It was believed that MOH could nourish kidney, strengthen bone and dispel dampness in Chinese medicine theory. MOH could mediate the bone modeling process by its components including anthraquinones, iridoid glycosides, oligosaccharides and polysaccharides …”

Section: Introductionmentioning

confidence: 99%

Integration of Zebrafish Model and Network Pharmacology to Explore Possible Action Mechanisms of Morinda officinalis for Treating Osteoporosis

Wang

Jiang

et al. 2020

Chemistry & Biodiversity

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Osteoporosis (OP) is a metabolic bone disease affecting nearly 200 million individuals globally. Morinda officinalis F.C.HOW (MOH) has long been used as a traditional herbal medicine for the treatment of bone fractures and joint diseases in China. However, it still remains unclear how the compounds in MOH work synergistically for treating OP. In this study, we used prednisolone (PNSL)-induced zebrafish OP model to screen the antiosteoporosis components in MOH. A network pharmacology approach was further proposed to explore the underlying mechanism of MOH on OP. The PNSL-induced zebrafish model validated that two anthraquinones, one iridoid glycoside, and two saccharides exerted antiosteoporotic effect. We constructed the componentstargets network and obtained the enriched Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. A total of 26 candidate compounds of MOH and 257 related targets could probably treat OP through regulating osteoclast differentiation and MAPK signaling pathway. Our work developed a strategy to screen the antiosteoporosis components and explore the underlying mechanism of MOH for treating OP at a network pharmacology level.

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“…Its long succulent roots were harvested and air-dried to be made into Chinese traditional medicine, Bajitian, currently known as one of the four major southern medicinal materials in China. Nowadays, the species is widely applied in the treatment of male impotence, female infertility, irregular menstruation, hypogastriccold pains and rheumatoid arthritis [3,4].…”

Section: Introductionmentioning

confidence: 99%

Characterization and novel Est-SSR marker development of an important Chinese medicinal plant, Morinda officinalis How (Rubiaceae)

Liao

Lee

Meng

et al. 2019

Biotechnology & Biotechnological Equipment

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Morinda officinalis How (Rubiaceae) is well known as one of the four most popular medicinal plants in the southern region of China. In order to assess its genetic diversity and assist the development of its molecular assisted-selection breeding in China, we constructed the transcriptome database of M. officinalis using fresh leaf material and developed novel expressed sequence tag-simple sequence repeat (EST-SSR) markers for this important medicinal plant species. Our study identified 8064 potential EST-SSRs from 6668 unigenes. For perfect repeat motifs, the mononucleotide repeats were most abundant (4221; 52.34%), followed by the trinucleotide repeats (1588; 19.69%), and the dinucleotide ones (1040; 12.90%). The seven most commonly occurring repeat motifs were A/T (4661), AG/CT (588), AAG/CTT (408), AC/GT (353), ATC/ATG (338), AT/AT (296) and AGG/CCT (277). Of a total of 5605 SSR primer sets that were successfully designed de novo, 100 were selected for validation analysis. There, 24 primer sets were polymorphic across the 96 M. officinalis individuals collected from four different populations in Guangdong province. Based on cross-species transferability test, 19 and 22 primer sets produced successful amplification in M. umbellata subsp. obovata and M. parvifolia, respectively. These novel EST-SSR markers with high cross-species transferability between M. officinalis and its closely-related species could serve as aids to future studies in genetic diversity, conservation, assisted-selection breeding and genes associated with the medical uses of the genus.

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Morinda officinalis How. – A comprehensive review of traditional uses, phytochemistry and pharmacology

Cited by 142 publications

References 29 publications

Indian Morinda species: A review

Indian Morinda species: A review

Integration of Zebrafish Model and Network Pharmacology to Explore Possible Action Mechanisms of Morinda officinalis for Treating Osteoporosis

Characterization and novel Est-SSR marker development of an important Chinese medicinal plant, Morinda officinalis How (Rubiaceae)

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