Morin Flavonoid Adsorbed on Mesoporous Silica, a Novel Antioxidant Nanomaterial

Abstract

Morin (2´,3, 4´,5,7-pentahydroxyflavone) is a flavonoid with several beneficial health effects. However, its poor water solubility and it sensitivity to several environmental factors avoid its use in applications like pharmaceutical and cosmetic. In this work, we synthetized morin-modified mesoporous silica nanoparticles (AMSNPs-MOR) as useful material to be used as potential nanoantioxidant. To achieve this, we characterized its adsorption kinetics, isotherm and the antioxidant capacity as hydroxyl radical (HO•) scavenger and singlet oxygen (1O2) quencher. The experimental data could be well fitted with Langmuir, Freundlich and Temkin isotherm models, besides the pseudo-second order kinetics model. The total quenching rate constant obtained for singlet oxygen deactivation by AMSNPs-MOR was one order of magnitude lower than the morin rate constant reported previously in neat solvents and lipid membranes. The AMSNPs-MOR have good antioxidant properties by itself and exhibit a synergic effect with morin on the antioxidant property against hydroxyl radical. This effect, in the range of concentrations studied, was increased when the amount of morin adsorbed increased.

Nanoantioxidant–Based Silica Particles as Flavonoid Carrier for Drug Delivery Applications

“…In general, the size does not vary significantly with the different functionalization steps, maintaining an average of 205 nm with a good polydispersity index lower than 0.3 ( Figure 2c, right y axis), except in the case of nano-RA/MH, where the average hydrodynamic diameter increases up to 250 nm with a PdI value of 0.52, probably due to the possible adsorption of morin in multilayers. This behavior has been previously reported by our group and is related to the coating properties of morin [47,48]. Nevertheless, any change in size was negligible and the zeta potential values ( Figure 2d) suggest a suitable colloidal stability.…”

“…Thus, to explain the behavior of MH release when the polyphenol RA is grafted in the nanoparticles, it is necessary to consider a possible layer-like arrangement on the surface. Mainly, the -OH and -C=O groups belonging to MH and RA can interact through hydrogen-bonding and due to the coating capacity of MH, form more than one surface layer that is not removed with washing after the synthesis [47,74,75]. As mentioned earlier, the release occurs in the SGF and SIF media, but when the pH increases, the MH and RA molecules are partially deprotonated and the electrostatic repulsive force between them facilitates the release, and the outer polyphenolic layers are removed, to a greater extent than at acidic pH, due to the process of MH desorption.…”

Nanoantioxidants: Recent Trends in Antioxidant Delivery Applications

“…Hence, there is a net increase of the reactive oxygen species (ROS) including superoxide anions, hydroxyl radicals (HO•), hydrogen peroxide (H 2 O 2 ), singlet oxygen ( 1 O 2 ), and reactive nitrogen species (RNS) (e.g., peroxynitrite, peroxyl radicals) [2]. ROS and RNS are generally induced by both endogenous routes include ROS generating enzymes, such as composite showed one magnitude lower 1 O 2 deactivation than morin in homogeneous solvents and lipid membranes, which in contrast exhibited a synergic effect on the antioxidant property against HO• and the effect is proportional to the concentration of morin adsorbed [41]. Similarly, mesoporous poly(tannic acid) (TA) crosslinked SiO 2 NPs composites were also tested for the antioxidant properties by preparing the nanocomposite via varying concentration of TA (50-1000 mg) and reaction times (2-24 h).…”

Synthesis of nanoparticle‐immobilized antioxidants and their antioxidative performances in polymer matrices: a review

“…2′,3,4′,5,7‐Pentahydroxyflavone (morin) is a flavonoid phenolic compound present in vegetables and plants and is beneficial to human health due to its antioxidative property. Arriagada et al . synthesized aminopropyl‐modified silica nanoparticles with mesoporous structure (AMSNPs) and prepared a nano‐antioxidant, AMSNPs‐MOR, based on the adsorption of morin.…”