Morin attenuates doxorubicin-induced heart and brain damage by reducing oxidative stress, inflammation and apoptosis

Kuzu, Müslüm; Kandemir, Fatih Mehmet; Yıldırım, Serkan; Küçükler, Sefa; Çağlayan, Cüneyt; Türk, Erdinç

doi:10.1016/j.biopha.2018.06.161

Cited by 133 publications

(70 citation statements)

References 49 publications

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“…Oxidative stress increases cytokine production by causing inflammation (Benzer, Kandemir, Kucukler, Comakli, & Caglayan, 2018;Kandemir et al, 2018). TNF-α has importance in initiation and regulation of cytokine cascade in immune response process (Kuzu et al, 2018). Also, several studies have reported that COX-2 increases TNF-α production (Benzer et al, 2018;Caglayan, Temel, Kandemir, Yildirim, & Kucukler, 2018;Hassan, Ghobara, & Abd-Allah, 2014).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of rutin on mercuric chloride‐induced reproductive damage in male rats

et al. 2020

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This study investigated the effects of rutin against reproductive damage caused by toxic mercury in male rats. Thirty‐five Sprague Dawley rats were used. Control group was injected with saline for 7 days. The rutin‐100 group received 100 mg/kg/b.w. rutin for 7 days. Mercuric chloride (HgCl2) group received 1.23 mg/kg/b.w. of HgCl2 for 7 days. Mercury chloride + rutin‐50 group received 50 mg/kg/b.w. rutin and HgCl2 1.23 mg/kg/b.w. for 7 days. HgCl2 + rutin‐100 group received 100 mg/kg/b.w. rutin and HgCl2 1.23 mg/kg/b.w. for 7 days. It was detected that HgCl2 treatment increased malondialdehyde (MDA) levels, tumour necrosis factor‐α (TNF‐α) and cyclooxygenase‐2 (COX‐2) expressions, necrosis and degeneration of spermatogonium, dead and abnormal sperm percentages; tubular walls thinning; and decreased antioxidant enzyme activities and sperm motility. It was determined that rutin application reduced testicular damage caused by HgCl2. In conclusion, rutin administration may treat HgCl2 toxicity in testes.

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Section: Discussionmentioning

confidence: 99%

Protective effect of rutin on mercuric chloride‐induced reproductive damage in male rats

et al. 2020

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“…Despite the broad spectrum of application, the clinical use of CYP is restricted because of its adverse effects, which include vomiting, nausea, bone marrow suppression, alopecia, hepatotoxicity, cardiotoxicity, nephrotoxicity, urotoxicity, neurotoxicity, and immunotoxicity . To overcome the side effects of the organ toxicity induced by chemotherapeutic drugs, safe cytoprotective antioxidants are necessary . Chrysin (CH) or 5,7‐dihydroxyflavone is a flavonoid present in various plants, bee propolis, and honey .…”

Section: Introductionmentioning

confidence: 99%

The antidiabetic and anticholinergic effects of chrysin on cyclophosphamide‐induced multiple organ toxicity in rats: Pharmacological evaluation of some metabolic enzyme activities

Taslimi

Kandemir

Demir

et al. 2019

J Biochem & Molecular Tox

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Chrysin (CH) or 5,7-dihydroxyflavone is a flavonoid present in various plants, bee propolis, and honey. Cyclophosphamide (CYP) is a chemotherapeutic drug, which is extensively used in the treatment of multiple human malignancies. In our study, we aimed to investigate the effects of CYP and CH on some metabolic enzymes including carbonic anhydrase, aldose reductase, paraoxonase-1, α-glycosidase, acetylcholinesterase, and butyrylcholinesterase enzyme activities in the brain, heart, testis, liver, and kidney tissues of rats. Thirty-five adult male Wistar rats were used.The animals were pretreated with CH (25 and 50 mg/kg b.w.) for seven days before administering a single dose of CYP (200 mg/kg b.w.) on the seventh day. In all the tissues, the treatment of CH significantly regulated these enzyme activities in CYP-induced rats. These results showed that CH exhibited an ameliorative effect against CYP-induced brain, heart, liver, testis, and kidney toxicity.chrysin, cyclophosphamide, enzyme activities, in vivo, metabolic enzymes, rats

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“…Flavonoids are found in many plants and are the natural polyphenols . Various epidemiological research showed that flavonoids which are found in dietary supplements prevented some diseases and attenuated the side effects of various over the counter drugs . Zingerone (ZO) is mainly found in dry ginger rhizome and a significant component of various spice plants .…”

Section: Introductionmentioning

confidence: 99%

The effects of zingerone against vancomycin‐induced lung, liver, kidney and testis toxicity in rats: The behavior of some metabolic enzymes

Çağlayan

Taslimi

Demir

et al. 2019

J Biochem & Molecular Tox

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In this study, it was demonstrated the ameliorative effect of zingerone (ZO) (25 and 50 mg/kg body weight) against vancomycin (VCM) (200 mg/kg body weight) administered to rats on some metabolic enzymes’ activities in the lung, liver, kidney, and testis tissues of rats. Forty‐two rats were divided into six groups as follows: control, ZO‐25, ZO‐50, VCM, VCM + ZO‐25, and VCM + ZO‐50. α‐Glycosidase, butyrylcholinesterase, aldose reductase, acetylcholinesterase, paraoxonase‐1, and carbonic anhydrase enzyme activities were significantly (P < .05) decreased in VCM group when compared with the control group. ZO, supplied with VCM, significantly activated some of these enzyme in all tissues. The results of this study showed that ZO regulates abnormal increases and decreases in VCM‐induced metabolic enzyme activities in all tissues.

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Morin attenuates doxorubicin-induced heart and brain damage by reducing oxidative stress, inflammation and apoptosis

Cited by 133 publications

References 49 publications

Protective effect of rutin on mercuric chloride‐induced reproductive damage in male rats

Protective effect of rutin on mercuric chloride‐induced reproductive damage in male rats

The antidiabetic and anticholinergic effects of chrysin on cyclophosphamide‐induced multiple organ toxicity in rats: Pharmacological evaluation of some metabolic enzyme activities

The effects of zingerone against vancomycin‐induced lung, liver, kidney and testis toxicity in rats: The behavior of some metabolic enzymes

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