More than the sum of its parts? Nutrition in Alzheimer's disease

Arnim, Christine A. F. Von; Gola, Ute; Biesalski, Hans Konrad

doi:10.1016/j.nut.2009.11.009

Cited by 55 publications

(44 citation statements)

References 79 publications

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“…This leads to multiple cellular alterations such as apoptosis and necrosis [12,37] . Additionally, studies demonstrated the implication of OS in several neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease [38,39] . Interestingly, our study showed that OS induced an activation of significantly larger volume area of brain suggesting thus the occurrence of brain plasticity and functional reorganization in these patients, and the phenomena was induced by free radicals.…”

Section: Discussionmentioning

confidence: 99%

Blood Oxygenation Level-Dependent Functional MRI of Early Evidences of Brain Plasticity after Hemodialysis Session by Helixone Membrane of Patients with Indices of Adrenal Deficiency

Boujraf¹,

Belaïch²,

Housni³

et al. 2017

Ann Neurosci

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Background: Various alterations of hypothalamic-pituitary-adrenal axis function have been described in patients with chronic renal failure. Nevertheless, controversial evidences were stated about the association between adrenal function deficiency (AD) and hemodialysis (HD). Purpose: The goal of this paper was to estimate indirect indices of the adrenal gland dysfunction which is potentially influenced by oxidative stress (OS) that still generates brain plasticity and reorganization of the functional control.Methods: Two male patients undergoing HD by the synthetic Helixone membrane for more than 6 months at the HD Center of the University Hospital of Fez, Fez, Morocco, were recruited. They underwent identical assessment immediately before and after the full HD session; this consisted of a blood ionogram revealing rates of sodium and calcium, and brain blood oxygenation level-dependent functional MRI (BOLD-fMRI) using a motor paradigm in block design. Results: The blood ionogram revealed hypercalcemia and hyponatremia in both patients. Both biological assessment and BOLD-fMRI study results revealed a high level of OS that induced activation of a significantly large brain volume area suggesting the occurrence of possible brain plasticity and functional control reorganization induced by free radicals and enhanced by AD. Conclusion: The occurrence of brain plasticity and functional control reorganization was demonstrated in both patients studied who were undergoing HD by BOLD-fMRI with a notable sensitivity; this plasticity is induced by elevated OS occasioned by HD technique itself and probably amplified by AD. Similar results were found in a previous study performed on the same patients undergoing HD by a polysulfone membrane.

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Section: Discussionmentioning

confidence: 99%

Blood Oxygenation Level-Dependent Functional MRI of Early Evidences of Brain Plasticity after Hemodialysis Session by Helixone Membrane of Patients with Indices of Adrenal Deficiency

Boujraf¹,

Belaïch²,

Housni³

et al. 2017

Ann Neurosci

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“…In contrast, interventional trials with antioxidants, B-vitamines and DHA did not give the promising expectations from the epidemiological data. As reported by Von Arnim et al, 2010, although some trials are encouraging, larger randomised clinical trials with combined supplements are needed to draw any conclusion. Supplement composition is still a matter of debate, because high doses of a single antioxidant have been associated with no beneficial effects for AD patients and even with an increase in mortality risk (e.g vitamin E).…”

Section: Multiple Nutrientsmentioning

confidence: 93%

Oxidative Stress in Alzheimer’s Disease: Pathogenesis, Biomarkers and Therapy

Gella¹,

Bolea²

2011

Alzheimer's Disease Pathogenesis-Core Concepts, Shifting Paradigms and Therapeutic Targets

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“…1,11 Studies that have investigated the role of nutrients and food in the aetiology of dementia include mono-and polyunsaturated fats, fatty fish and the Mediterranean diet. [14][15][16][17][18][19][20][21] It is suggested that diets lower in saturated fat and cholesterol are associated with decreased rates of dementia, possibly through the maintenance of neuronal membranes. [14][15][16][17][18][19][20] Antioxidants may also be protective against developing dementia, as oxidative stress is postulated to be involved in neuronal death and therefore cognitive decline.…”

Section: 12mentioning

confidence: 99%

“…[14][15][16][17][18][19][20][21] It is suggested that diets lower in saturated fat and cholesterol are associated with decreased rates of dementia, possibly through the maintenance of neuronal membranes. [14][15][16][17][18][19][20] Antioxidants may also be protective against developing dementia, as oxidative stress is postulated to be involved in neuronal death and therefore cognitive decline. 14,16,18,21 In addition, adequate intake of B vitamins and folate is associated with lower risk of developing dementia by reducing serum homocysteine levels, which is often associated with cognitive decline.…”

Section: 12mentioning

confidence: 99%

Nutrition and dementia care: Informing dietetic practice

Jansen

Ball

Desbrow

et al. 2014

Nutrition & Dietetics

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Aim: The increasing prevalence of dementia and the nutritional complications associated with dementia suggest an increasing need for health care that focuses on nutrition and dietetic support. The aim of this paper was to summarise existing evidence relating to nutrition in the aetiology, prevention and management of dementia in order to help inform dietitians in the provision of care to people with dementia, their families and carers. Methods: A literature search was undertaken to identify relevant research that investigated the nutritional aetiology of dementia, the effectiveness of nutrition in the prevention and treatment of dementia, or strategies used by carers to provide nutrition-related support to people with dementia. Results: There is currently insufficient evidence to support specific nutrition-related dementia causality. The role of specific nutrients in slowing cognitive decline in people with dementia is also unclear. People with dementia rarely maintain a stable body weight and often incur numerous feeding-related challenges that contribute to the risk of malnutrition. High-calorie dietary supplements may enhance the short-term energy intake of people with dementia but are unlikely to improve long-term weight management or other dementia-related outcomes. Conclusions: Practical, achievable strategies that focus on food items and eating environments to promote oral intake of people with dementia while minimising carer burden should be a focus for nutrition and dietetic interventions.

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More than the sum of its parts? Nutrition in Alzheimer's disease

Cited by 55 publications

References 79 publications

Blood Oxygenation Level-Dependent Functional MRI of Early Evidences of Brain Plasticity after Hemodialysis Session by Helixone Membrane of Patients with Indices of Adrenal Deficiency

Blood Oxygenation Level-Dependent Functional MRI of Early Evidences of Brain Plasticity after Hemodialysis Session by Helixone Membrane of Patients with Indices of Adrenal Deficiency

Oxidative Stress in Alzheimer’s Disease: Pathogenesis, Biomarkers and Therapy

Nutrition and dementia care: Informing dietetic practice

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