<p> <span style="font-size:10.0pt;">Magnetic Resonance Spectroscopy (MRS) is nowadays considered as a main MRI investigation modality in the clinical routine jointly with conventional anatomical and functional magnetic resonance imag- ing for studying brain tumours. MRS provides complementary information about cellular metabolism. This allows differentiating the brain tumours from abscess, the diagnosis of the tumour type, characterization of brain tumours, as well as local study of the <span>morphological abnormalities observed in conventional </span>MRI. The MRS could be used in the therapeutic follow-up for evaluating the pathological active area of brain, and allows optimizing the guided biopsy as well <span>as to differentiating recurrent tumour from a necrosis.</span></span><b><span style="font-size:10.0pt;"> </span></b><b><span style="font-size:10.0pt;"></span></b> </p>

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This work purpose was to estimate the implication of suspected adrenal function deficiencies, which was influenced by oxidative stress (OS) that are generating brain plasticity, and reorganization of the functional control. This phenomenon was revealed in two-hemodialysis patients described in this paper. Blood oxygenation level dependent functional magnetic resonance imaging (BOLD-fMRI) revealed a significant activation of the motor cortex. Hemodialysis seems to originate an inflammatory state of the cerebral tissue reflected by increased OS, while expected to decrease since hemodialysis eliminates free radicals responsible for OS. Considering adrenal function deficiencies, sensitivity to OS and assessed hyponatremia and hypercalcemia, adrenal function deficiencies is strongly suspected in both patients. This probably contributes to amplify brain plasticity and a reorganization of functional control after hemodialysis that is compared to earlier reported studies. Brain plasticity and functional control reorganization was revealed by BOLD-fMRI with a remarkable sensitivity. Brain plastic changes are originated by elevated OS associating indices of adrenal function deficiencies. These results raise important issues about adrenal functional deficiencies impact on brain plasticity in chronic hemodialysis-patients. This motivates more global studies of plasticity induced factors in this category of patients including adrenal functional deficiencies and OS.

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Objectives:The primary lymphoma of the central nervous system is a cancer rare. The diagnosis of this tumoral entity must be considered as an emergency considering the therapeutical involved. Therefore, we report this entity while reporting diagnostic challenges.Patients and Methods:Unfortunately, the conventional clinical and imaging signs can be confusing and might contribute to delay the diagnosis process of potentially curable pathological entity. The diagnosis confirmation in immunocompetent patients is based on a stereotaxic biopsy.Results and Conclusion:In this paper, we report a case illustrating the contribution of multimodal imaging including diffusion-weighted magnetic resonance imaging (MRI), diffusion tensor MRI, perfusion MRI, and proton MR spectroscopy to the diagnostic approach of the atypical primary lymphoma of the central nervous system.

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