More than static: altered dynamic functional connectivity of primary visual cortex in the comitant exotropia patients

Abstract

Previous neuroimaging studies have demonstrated that comitant exotropia (CE) patients exhibit dysfunction in various visual cortical areas. However, whether the CE patients showed abnormal dynamic functional connectivity (dFC) in primary visual cortex (V1) changes remains unknown. A total of 36 CE patients (25 males and 11 females) and 36 well-matched healthy control subjects (HCs) were enrolled in the study. The dFC with sliding window method was applied to investigate the dynamic functional connectivity changes in primary visual cortex (V1). Compared with HCs, CE patients had decreased dFC values between left V1 and right fusiform (Fus), right lingual (LING), left orbital medial frontal gyrus, left Fus, left calcarine and left precuneus (PreCUN). Meanwhile, CE patients had decreased dFC values between right V1 and left cerebelum_6 (CER_6), right lingual and left inferior occipital gyrus. Our study demonstrates that CE patients showed altered dFC within visual network and V1-default mode network, which might indicate the decreased variability FC values in the primary visual cortex in CE patients.

Altered dynamic functional connectivity in the primary visual cortex in patients with primary angle-closure glaucoma

“…All preprocessing was performed using the toolbox for Data Processing and Analysis of Brain Imaging (DPABI) 1 ( Yan et al, 2016 ), which is based on the Statistical Parametric Mapping (SPM12) 2 implemented in MATLAB 2013a (MathWorks, Natick, MA, USA) and the details of steps according to a previous study ( Chen et al, 2022 ).…”

“…All preprocessing was performed using the toolbox for Data Processing and Analysis of Brain Imaging (DPABI) 1 (Yan et al, 2016) MA, USA) and the details of steps according to a previous study (Chen et al, 2022).…”

Resting-State Functional Connectivity of the Primary Visual Cortex in Children with Anisometropia Amblyopia

“…BA17 was designated as ROI for brain FC analysis [16]. The mean value of preconditioned FC underwent a Fisher Z transformation to mitigate the impact of individual differences during population statistical comparison.…”

“…(7) The image was processed by 0.01-0.08 Hz low-frequency filtering to eliminate physiological noise outside the band. ROI Definition BA17 was designated as ROI for brain FC analysis [16]. The mean value of preconditioned FC underwent a Fisher Z transformation to mitigate the impact of individual differences during population statistical comparison.…”