Altered dynamic functional connectivity in the primary visual cortex in patients with primary angle-closure glaucoma

Li, Dongjin; Huang, Bing-Lin; Yuan, Peng; Liang, Ling-Yan; Liu, Hui

doi:10.3389/fnins.2023.1131247

Cited by 7 publications

(3 citation statements)

References 25 publications

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“…Our study found enhanced functional connectivity in the visual network of PACG patients, consistent with the results of Li et al (51). However, Dai et…”

Section: Discussionsupporting

confidence: 93%

Topological Organization of the Brain Network in Patients with Primary Angle-closure Glaucoma Through Graph Theory Analysis

Chen,

Li,

Huang

2024

Brain Topogr

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Primary angle-closure glaucoma (PACG) is an irreversible blinding eye disease. Previous neuroimaging studies have reported abnormal brain function changes in PACG patients, but the potential association of PACG with changes in brain functional networks remains unknown. This study aims to investigate the impact of PACG on brain networks, with the goal of enhancing understanding of its neurobiological mechanisms for improved diagnosis and treatment through the application of graph theory analysis. MethodA cohort comprising 44 PACG patients and 44 healthy controls was recruited for the study. Functional brain networks were constructed based on fMRI data utilizing the Automated Anatomical Labeling 90 template. Subsequently, graph theory analysis was conducted to assess global metrics, nodal metrics, modular organization, and network-based statistics(NBS), facilitating a comparative analysis between PACG patients and the control group. ResultThe global metrics( including small world and network e ciency) did not reveal signi cant differences between the two groups. However, PACG patients showed increased nodal metrics (including centrality and e ciency) in the left frontal superior medial, right frontal superior medial, and right posterior central brain regions, alongside decreased values in the right temporal superior gyrus region compared with health controls. Moreover, Module 5 demonstrated signi cant differences in intra-module connectivity, while signi cant variations in inter-module connectivity were observed between Module 1 and Module 7, as well as Module 1 and Module 8. Notably, the NBS analysis revealed a signi cantly modi ed network when comparing the PACG and HC groups. Conclusionthe study suggests that PACG patients exhibit differences in nodal metrics and modularity of functional brain networks, with changes observed mainly in prefrontal, occipital, and temporal lobes, as well as cerebellar regions. However, global metrics analysis indicates that the global connectivity patterns of the entire brain network remain unchanged in PACG patients. These ndings may serve as potential biomarkers for early diagnosis and differential diagnosis of PACG, and interventions targeting brain regions with high degree centrality and nodal e ciency may help to optimize therapeutic strategies.With the advancement of neuroimaging techniques, functional magnetic resonance imaging (fMRI) has emerged as a non-invasive method for measuring blood oxygen level-dependent (BOLD) signals in diverse brain regions, offering valuable insight into neural activity. ( 14). fMRI plays a pivotal role in investigating the neural mechanism alterations associated with glaucoma. Prior research has revealed varying degrees of changes in brain structure and function in glaucoma patients. For instance, a study by Jiang found differences in the whole brain grey matter volume of glaucoma patients, primarily concentrated in multiple brain regions relevant to visual motion function, the thalamocortical pathway, and emotional function. These regions incl...

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“…Our study found enhanced functional connectivity in the visual network of PACG patients, consistent with the results of Li et al (51). However, Dai et…”

Section: Discussionsupporting

confidence: 93%

Topological Organization of the Brain Network in Patients with Primary Angle-closure Glaucoma Through Graph Theory Analysis

Chen,

Li,

Huang

2024

Brain Topogr

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“…Some scholars have utilized rs-fMRI to determine whether amblyopic patients have functional changes in the brain areas along this pathway, i.e., from the cerebellum, inferior parietal lobule to V1 [27][28][29][30][31][32] . A similar study found that the functional connection between the right anterior cerebellar lobe and primary visual cortex is decreased in patients with glaucoma-associated optic nerve damage, and even the higher visual cortex has similar manifestations, suggesting that there is a decline in visual integration in these patients [33] . It is suggested that the decrease in the function of the anterior cerebellar lobe may be caused by the decrease in information input in the primary or higher visual cortex.…”

Section: Discussionmentioning

confidence: 68%

Brain mechanism of acupuncture for children with anisometropic amblyopia: a resting functional magnetic resonance imaging study based on voxel-mirrored homotopic connectivity

Wang,

Sun,

et al. 2024

Int J Ophthalmol

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AIM: To explore the brain mechanism of acupuncture for children with anisometropic amblyopia using the voxel-mirror homotopic connectivity (VMHC) analysis method of resting functional magnetic resonance imaging (rs-fMRI) technology based on clinical effectiveness. METHODS: Eighty children with anisometropic monocular amblyopia were randomly divided into two groups: control (40 cases, 1 case of shedding) and acupuncture (40 cases, 1 case of shedding) groups. The control group was treated with glasses, red flash, grating, and visual stimulations, with each procedure conducted for 5min per time. Based on routine treatment, the acupuncture group underwent acupuncture of “regulating qi and unblocking meridians to bright eyes”, Jingming (BL1), Cuanzhu (BL2), Guangming (GB37), Fengchi (GB20) acupoints were taken on both sides, with the needle kept for 30min each time. Both groups were treated once every other day, three times per week, for a total of 4wk. After the treatment, the overall curative effect of the two groups and the latency and amplitude changes of P100 wave of pattern visual-evoked potential were counted. At the same time, nine children with left eye amblyopia were randomly selected from the two groups and were scanned with rs-fMRI before and after treatment. The differences in the brain regions between the two groups were compared and analyzed with VMHC. RESULTS: Chi-square test showed a notable difference in the total efficiency rate between the acupuncture (94.87%) and control groups (79.49%). Regarding the P100 wave latency and amplitude, the acupuncture group had significantly shorter latency and higher amplitude of P100 wave than the control group. Moreover, the VMHC values of the bilateral temporal lobe, superior temporal gyrus, and middle temporal gyrus were notably increased in the acupuncture group after treatment. CONCLUSION: Acupuncture combined with conventional treatment can significantly improve the corrected visual acuity and optic nerve conduction in children with anisometropic amblyopia. Compared with the conventional treatment, the regulation of acupuncture on the functional activities of the relevant brain areas in the anterior cerebellum may be an effective acupuncture mechanism for anisometropic amblyopia.

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“…Structurally, patients with glaucoma exhibit white matter tract damage far beyond visual pathway localization 34 . Functionally, PACG patients show visual dysfunction and vision-related cortex dysfunction 35 , 36 . These studies suggest that PACG patients have abnormalities in their visual networks, both structurally and functionally.…”

Section: Discussionmentioning

confidence: 99%

Altered static and dynamic functional network connectivity in primary angle-closure glaucoma patients

Wang,

Shu,

Cai

et al. 2024

Sci Rep

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To explore altered patterns of static and dynamic functional brain network connectivity (sFNC and dFNC) in Primary angle-closure glaucoma (PACG) patients. Clinically confirmed 34 PACG patients and 33 age- and gender-matched healthy controls (HCs) underwent evaluation using T1 anatomical and functional MRI on a 3 T scanner. Independent component analysis, sliding window, and the K-means clustering method were employed to investigate the functional network connectivity (FNC) and temporal metrics based on eight resting-state networks. Differences in FNC and temporal metrics were identified and subsequently correlated with clinical variables. For sFNC, compared with HCs, PACG patients showed three decreased interactions, including SMN-AN, SMN-VN and VN-AN pairs. For dFNC, we derived four highly structured states of FC that occurred repeatedly between individual scans and subjects, and the results are highly congruent with sFNC. In addition, PACG patients had a decreased fraction of time in state 3 and negatively correlated with IOP (p < 0.05). PACG patients exhibit abnormalities in both sFNC and dFNC. The high degree of overlap between static and dynamic results suggests the stability of functional connectivity networks in PACG patients, which provide a new perspective to understand the neuropathological mechanisms of optic nerve damage in PACG patients.

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Altered dynamic functional connectivity in the primary visual cortex in patients with primary angle-closure glaucoma

Cited by 7 publications

References 25 publications

Topological Organization of the Brain Network in Patients with Primary Angle-closure Glaucoma Through Graph Theory Analysis

Topological Organization of the Brain Network in Patients with Primary Angle-closure Glaucoma Through Graph Theory Analysis

Brain mechanism of acupuncture for children with anisometropic amblyopia: a resting functional magnetic resonance imaging study based on voxel-mirrored homotopic connectivity

Altered static and dynamic functional network connectivity in primary angle-closure glaucoma patients

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