More on recombination and selection in the modifier theory of sex-ratio distortion

Feldman, Marcus W.; Otto, Sarah P.

doi:10.1016/0040-5809(89)90018-x

Cited by 12 publications

(10 citation statements)

References 20 publications

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“…This result is reflected in some other studies of meiotic drive. For example, reduced recombination is expected to evolve between an X chromosome that experiences drive and another selected locus (Feldman and Otto 1989;Rydzewski et al 2016), and new male determining alleles can be favored when they appear in linkage to a locus that experiences drive in males (Úbeda et al 2015). These studies reinforce the view that sex-specific meiotic drive can affect the evolution of recombination, often in a similar manner to sex-specific diploid selection.…”

Section: Discussionmentioning

confidence: 99%

“…However, increased recombination is never favored when modifiers of recombination act locally, such that they are also closely linked to the SDR. In a previous study, Feldman and Otto (1989) considered meiotic drive alleles that target the SDR and included no diploid selection. Numerically, Feldman and Otto (1989) also identified cases where loosely linked modifiers favor increased recombination, which parallels our results under gametic competition.…”

Section: Discussionmentioning

confidence: 99%

“…In a previous study, Feldman and Otto (1989) considered meiotic drive alleles that target the SDR and included no diploid selection. Numerically, Feldman and Otto (1989) also identified cases where loosely linked modifiers favor increased recombination, which parallels our results under gametic competition. Overall, while these dynamics may influence the maintenance of small amounts of recombination around SDRs when polymorphisms with the right form of selection arise (e.g., within the colored regions in Figure A1), suppressed recombination will be favored in most circumstances.…”

Section: Discussionmentioning

confidence: 99%

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Haploid Selection Favors Suppressed Recombination Between Sex Chromosomes Despite Causing Biased Sex Ratios

Scott

Otto

2017

Genetics

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To date, research on the evolution of sex chromosomes has focused on sexually antagonistic selection among diploids, which has been shown to be a potent driver of the strata and reduced recombination that characterize many sex chromosomes. However, significant selection can also occur on haploid genotypes during less conspicuous life cycle stages, , competition among sperm/pollen or meiotic drive during gamete/spore production. These haploid selective processes are typically sex-specific,, gametic/gametophytic competition typically occurs among sperm/pollen, and meiotic drive typically occurs during either spermatogenesis or oogenesis. We use models to investigate whether sex-specific selection on haploids could drive the evolution of recombination suppression on the sex chromosomes, as has been demonstrated for sex-specific selection among diploids. A potential complication is that zygotic sex-ratios become biased when haploid selected loci become linked to the sex-determining region because the zygotic sex ratio is determined by the relative number and fitness of X- Y-bearing sperm. Despite causing biased zygotic sex-ratios, we find that a period of sex-specific haploid selection generally favors recombination suppression on the sex chromosomes. Suppressed recombination is favored because it allows associations to build up between haploid-beneficial alleles and the sex that experiences haploid selection most often (, pollen beneficial alleles become strongly associated with the male determining region, Y or Z). Haploid selected loci can favor recombination suppression even in the absence of selective differences between male and female diploids. Overall, we expand our view of the sex-specific life cycle stages that can drive sex chromosome evolution to include gametic competition and meiotic drive. Based on our models, sex chromosomes should become enriched for genes that experience haploid selection, as is expected for genes that experience sexually antagonistic selection. Thus, we generate a number of predictions that can be evaluated in emerging sex chromosome systems.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Haploid Selection Favors Suppressed Recombination Between Sex Chromosomes Despite Causing Biased Sex Ratios

Scott

Otto

2017

Genetics

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“…If genes that modify the recombination rate are themselves tightly linked to the SDR (low R m and R f ), modifier alleles will spread only if they reduce recombination; in particular, inversions close to the SDR would always be favoured. The fact that loosely linked modifiers are more conducive to the maintenance of recombination between the sex chromosomes echoes work on modifiers of recombination in the presence of sex ratio distortion (Feldman & Otto, ), where the SDR experiences segregation distortion at a rate that depends on a sex ratio distorter gene lying within the PAR (the latter being equivalent to the A locus). There too, increased recombination between the sex chromosomes is most likely when the modifier of recombination is loosely linked, because of the short‐term benefits of equalizing the sex ratio.…”

Section: Discussionmentioning

confidence: 99%

Selective maintenance of recombination between the sex chromosomes

Otto

2014

J of Evolutionary Biology

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A hallmark of many sex chromosomes is the dramatically reduced rate of recombination between them in the heterogametic sex (e.g. between the X and Y). Sexually antagonistic selection is thought to be the main selective driver of this reduced recombination, with tighter linkage strengthening the association between alleles favourable to females and the X, as well as alleles favourable to males and the Y. Nevertheless, many sex chromosomes retain substantial levels of recombination over millions of years, and some old sex chromosomes remain homomorphic with few signs of recombination suppression and the chromosomal degradation expected to follow. This paper explores the selective factors that can maintain recombination between the sex chromosomes. Specifically, by analysing the dynamics of genes that modify the rate of recombination, I present results demonstrating that certain forms of selection -all involving overdominance in males -can positively maintain recombination in the pseudo-autosomal region. To understand these cases, one has to revise our standard view of sexual antagonistic selection as involving two partners (males and females) to three partners (the X in females, the X in males and the Y).

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“…Maffi and Jayakar studied the case of two alleles, Al and A2, and the multiple-allele case was analyzed by Lessard (1987). For the present purposes, it is enough to concentrate on the two-allele case, for which new phenomena have recently been discovered (Feldman and Otto 1989).…”

Section: Sex-ratio Distortion In Aedes Aegyptimentioning

confidence: 99%

A Comparative Approach to the Population-Genetics Theory of Segregation Distortion

Feldman¹,

Otto²

1991

The American Naturalist

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Mathematical models of four well-known naturally occurring systems of segregation distortion are compared. These include the sex-ratio chromosome of Drosophila pseudoobscura, the Segregation Distorter (SD) complex of D. melanogaster, the t locus in Mus musculus, and the sex-ratio system in Aedes aegypti. Dynamics of these models are compared with the classical one-locus multiple-allele viability system. For the SD complex and the sex-ratio model of A. aegypti, the role of recombination is reviewed. Departures from Mendelian segregation cause fascinating irregularities in the relationship between linkage and linkage disequilibrium, as well as in predictions for the evolution of recombination itself.

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More on recombination and selection in the modifier theory of sex-ratio distortion

Cited by 12 publications

References 20 publications

Haploid Selection Favors Suppressed Recombination Between Sex Chromosomes Despite Causing Biased Sex Ratios

Haploid Selection Favors Suppressed Recombination Between Sex Chromosomes Despite Causing Biased Sex Ratios

Selective maintenance of recombination between the sex chromosomes

A Comparative Approach to the Population-Genetics Theory of Segregation Distortion

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