2022
DOI: 10.1002/jmv.28025
|View full text |Cite
|
Sign up to set email alerts
|

MORC3 restricts human cytomegalovirus infection by suppressing the major immediate‐early promoter activity

Abstract: During the long coevolution of human cytomegalovirus (HCMV) and humans, the host has formed a defense system of multiple layers to eradicate the invader, and the virus has developed various strategies to evade host surveillance programs. The intrinsic immunity primarily orchestrated by promyelocytic leukemia (PML) nuclear bodies (PML-NBs) represents the first line of defense against HCMV infection. Here, we demonstrate that microrchidia family CW-type zinc finger 3 (MORC3), a PML-NBs component, is a restrictio… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

1
13
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 5 publications
(14 citation statements)
references
References 51 publications
(112 reference statements)
1
13
0
Order By: Relevance
“…The focus of this study was to understand the role of MORC3 upregulation and activity in the establishment and maintenance of latency. SUMOylated MORC3, associated with PML, is known to mediate transcriptional repression in a Daxx‐dependent manner 19–21 . However, our data suggest that MORC3‐mediated repression of the MIEP during latency is unlikely to involve SUMOylated MORC3 or its interaction with PML/Daxx for a number of reasons.…”
Section: Discussionmentioning
confidence: 66%
See 4 more Smart Citations
“…The focus of this study was to understand the role of MORC3 upregulation and activity in the establishment and maintenance of latency. SUMOylated MORC3, associated with PML, is known to mediate transcriptional repression in a Daxx‐dependent manner 19–21 . However, our data suggest that MORC3‐mediated repression of the MIEP during latency is unlikely to involve SUMOylated MORC3 or its interaction with PML/Daxx for a number of reasons.…”
Section: Discussionmentioning
confidence: 66%
“…The data presented here demonstrate that MORC3 plays an important role in repressing viral MIEP activity to establish and maintain HCMV latency. This is in contrast to lytic infection where MORC3 is degraded to enhance MIEP activity 21,24 . Thus we propose a balanced model of MORC3 upregulation during latency and downregulation during reactivation/lytic infection.…”
Section: Discussionmentioning
confidence: 80%
See 3 more Smart Citations