MORC3 represses the HCMV major immediate early promoter in myeloid cells in the absence of PML nuclear bodies
Anna Champion,
Alexandra Rowland,
Levia Yee
et al.
Abstract:Human cytomegalovirus (HCMV) can undergo either a latent or a lytic infection in cells of the myeloid lineage. Whilst the molecular mechanisms which determine the outcome of infection are far from clear, it is well established that a key factor is the differential regulation of the major immediate early promoter (MIEP) responsible for driving lytic immediate early gene expression. Using a myelomonocytic cell line stably transduced with a GFP reporter under the control of the MIEP, which recapitulates MIEP regu… Show more
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