Morbihan disease

Hu, Stephanie W.; Robinson, Maria M.; Meehan, Shane A; Cohen, David E.

doi:10.5070/d37rc0m3ks

Cited by 19 publications

(12 citation statements)

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“…Previously, inflammatory reactions to cosmetic product use or Demodex infestation have been suggested to be possible inciting factors for Morbihan syndrome. 2,7 More recently, discoveries made in understanding the pathophysiology of non-insulin-dependent diabetes mellitus have shown how impaired nitric oxide signaling can disrupt lymphatic vascular integrity, which has important associations to the pathophysiology of Morbihan syndrome. 8 This new study supports findings from previous studies on diabetic rats, which revealed induced lymphatic flow abnormalities that were restored following insulin-based control of blood glucose.…”

Section: Discussionmentioning

confidence: 99%

Morbihan disease: A diagnostic dilemma: two cases with successful resolution

Donthi

Nenow

Samia

et al. 2021

SAGE Open Medical Case Reports

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Morbihan syndrome is a rare entity characterized by persistent erythema and solid edema of upper two-thirds of the face. Although its etiology is poorly understood, it is known to have a wide differential diagnosis and is frequently under-recognized.1–3 We report two such cases of Morbihan syndrome in patients that responded well to treatment with a combination of 2.5% hydrocortisone cream, brimonidine 0.33% topical gel, metronidazole gel and 100 mg doxycycline twice daily. This report emphasizes the necessity of biopsy for clinical correlation in cases of chronic facial edema. It also serves to highlight a potential association of Morbihan syndrome to diabetes mellitus through recently discovered pathophysiology of diabetes on the lymphatic system. It underscores the effectiveness of our therapeutic regimen in the context of other treatment regimen effectiveness. Finally, it highlights novel advances into the diagnosis and treatment of the disease.

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Section: Discussionmentioning

confidence: 99%

Morbihan disease: A diagnostic dilemma: two cases with successful resolution

Donthi

Nenow

Samia

et al. 2021

SAGE Open Medical Case Reports

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“…11 Systemic corticosteroids, oral tetracyclines, clofazimine or isotretinoin have been used, but there is no consensus on treatment. 12…”

Section: Morbihan's Diseasementioning

confidence: 99%

“…The refractory nature of the edema and its well‐demarcated site may differentiate this entity from angioedema 11 . Systemic corticosteroids, oral tetracyclines, clofazimine or isotretinoin have been used, but there is no consensus on treatment 12 …”

Section: Inflammatory Causesmentioning

confidence: 99%

If not angioedema, what is it? Diagnostic approach to facial edema

Velasco‐Amador,

Prados‐Carmona,

Navarro‐Triviño

2024

J Deutsche Derma Gesell

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SummaryFacial edema is a relatively frequent clinical presentation encountered in patients seen in allergology and dermatology clinics. The differential diagnosis is broad, and sometimes the definitive diagnosis can be a challenge for the clinician. Facial angioedema itself encompasses different etiopathologies (histaminergic, bradykinergic, etc.) that must be distinguished from other causes of facial edema, such as allergic contact dermatitis, granulomatous conditions, inflammatory causes, infections, neoplasms or paraneoplastic syndromes, autoimmune diseases, among other entities hereby referred as miscellanea. A proper diagnostic approach is essential to order the appropriate tests, as well as to prescribe a targeted treatment. This review focuses on entities that present with facial edema and summarize their characteristic clinical features.

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“…Morbihan syndrome is a rare disorder wherein woody non-pitting edema with erythema occurs in the upper half of the face. [1][2][3] The etiology remains undetermined, but is considered related to rosacea and acne vulgaris. 1 Although uncommon, Morbihan syndrome should be considered a potential cause of bilateral upper-eyelid swelling, particularly when the patient has history or complications of rosacea and acne vulgaris.…”

mentioning

confidence: 99%

“…The pathology of Morbihan syndrome can be non-specific or show lymphocytic infiltration and edema. 1,2 Treatment options include oral isotretinoin or tetracycline; however, Morbihan syndrome is frequently refractory and may require surgical resection for complete recovery. [1][2][3] Figure 1 The patient's face showing dilated capillaries around the nose and bilateral cheeks and erythematous edema involving the bilateral upper eyelids at first presentation…”

mentioning

confidence: 99%