Morbidity and Mortality Patterns in Children Admitted to Hospital in Thai Binh, Vietnam: A Five-year Descriptive Study with a Focus on Infectious Diseases

Pham, Thi Dung; Hoang, Van Thuan; Dao, Thi Loi; Tran, Xuan Duong; Phi, Duc Long; To, Minh Manh; Dang, Van Nghiem; Dao, Thanh; Nguyen, Nam Thang; Vu, Thi Thuy; Nguyen, Duc Thanh; Nguyen, Duy Cuong; Hoang, Nang Trong; Vu, Thanh Liem; Nguyen, Thi Minh Chinh; Minodier, Philippe

doi:10.2991/jegh.k.200723.001

Cited by 9 publications

(14 citation statements)

References 27 publications

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“…Patients present at TBPH either directly from their homes or when referred from district hospitals. Children can be transferred to the National Hospital of Paediatrics in Hanoi when the medical situation goes beyond the expertise available at TBPH [ 11 , 12 ]. The average number of monthly hospitalisations is around 2,000 and is often more, especially during the peak of infections [ 12 ].…”

Section: Methodsmentioning

confidence: 99%

Aetiology of Acute Undifferentiated Fever Among Children Under the Age of Five in Vietnam: A Prospective Study

Tran

Hoang

Dang

et al. 2023

J Epidemiol Glob Health

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Background To investigate the aetiology of acute undifferentiated fever (AUF) among children under the age of five in Vietnam. Methods This prospective study was conducted in the Thai Binh paediatric hospital, between July 2020 and July 2021 among children with AUF at admission. Real-time PCR testing 18 microbial pathogens were done on blood samples. Results 286 children were included, with median age of 16 months. 64.7% were male. 53.9% were positive for at least one pathogen by PCR. Enterovirus, human herpesvirus 6, adenovirus, and varicella zoster virus PCR were positive for 31.1, 12.6, 1.4, and 1.0% patients, respectively. Other pathogens tested negative by PCR. During the hospital stay, based on clinical criteria 47.2% children secondarily presented with signs of respiratory tract infections, 18.9% had hand, foot and mouth disease, 4.6% had chickenpox. 4.2% presented signs of central nervous system infections, 1.0% had dengue (antigenic test) and 1.0% had signs of gastrointestinal infection. Finally, 23.1% patients presented a fever with or without a rash and no other symptoms and ultimately received a diagnosis of AUF. Conclusion Real-time PCR of blood is useful for detecting pathogens and diagnosing infectious causes of AUF. Further prospective studies with blood and urine culture testing and PCR investigation of not only blood but also cerebrospinal fluid, throat, and skin samples according to symptoms would be of interest to confirm the predominance of viral infections in children with AUF and to guide therapeutic options.

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Section: Methodsmentioning

confidence: 99%

Aetiology of Acute Undifferentiated Fever Among Children Under the Age of Five in Vietnam: A Prospective Study

Tran

Hoang

Dang

et al. 2023

J Epidemiol Glob Health

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“…Children with severe disease who do not improve are transferred to the Vietnam National Children’s Hospital in Hanoi (VNCH). The identification of microorganisms in the laboratory is very limited, relying mainly on common bacterial culture and serological tests [ 4 ].…”

Section: Methodsmentioning

confidence: 99%

“…In Thai Binh, Viet Nam, CNS infections, including meningitis and encephalitis, are frequent infectious diseases in children [ 4 ]. In our preliminary report, 250 patients with CNS infections were diagnosed over the course of 5 years (2015–2019) in the Thai Binh Pediatric Hospital (TBPH), corresponding to approximately 4 cases per month.…”

Section: Introductionmentioning

confidence: 99%

Outbreak of central nervous system infections among children in Thai Binh, Viet Nam

Phi

Tran

et al. 2022

Emerging Microbes & Infections

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From July to October 2020, 99 cases of central nervous system (CNS) infections were identified in Thai Binh Pediatric Hospital, Viet Nam, representing a five-fold increase compared to the baseline incidence during the previous five years. Clinical data were retrospectively collected. Cerebrospinal fluid specimens (CSF) were secondarily tested for pathogens using viral culture and PCR assays. Patient median age was 5 years (0–12 years); 58.6% were male. Of these children, 83.8% had CSF white blood culture (WBC) counts of ≥ 10 cells/µL, including 58 of 99 (58.6%) with a WBC count ≥ 100 cells/µL. Overall, 72 (72.7%) patients had confirmed infections with a pathogen identified in the CSF, the majority of which (66) were enterovirus. Sequencing results suggested that the rise of incidence observed in 2020 was due to Echovirus 4 ( n = 45), Echovirus 30 ( n = 8), and Echovirus 6 ( n = 1) circulation. A confirmed CNS infection was significantly associated with older age (≥5 years, OR = 3.64, p = 0.03) and with an increased WBC count in the CSF (OR = 6.38, p -value = 0.01 for WBCs from 10 to <100 and OR = 7.90, p -value = 0.002 for WBCs ≥100). Ninety-seven (97) of 99 (98.0%) children received empiric antimicrobial treatment, and 35 (35.3%) were treated with multiple antibiotics. Eighty-four (84) patients (84.9%) were discharged home, and 11 (11.1%) were transferred to the National Hospital because their condition had worsened. No deaths were recorded. Point-of-care tests, including real-time PCR assays to identify common pathogens, should be implemented for more accurate diagnosis and more appropriate antibiotic use.

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“…In 2019, this hospital had 565 beds spread across 15 different medical departments, including an outpatient department. Microbiological identification in the hospital laboratory uses common bacteriological cultures, serological assays and real-time polymerase chain reaction (PCR) for a limited number of pathogens [ 12 ].…”

Section: Methodsmentioning

confidence: 99%

Effect of the COVID-19 Outbreak on the Incidence of Other Respiratory and Gastrointestinal Infections in Children in Thai Binh, Vietnam in 2020

Nguyen

Dao

Pham

et al. 2022

J Epidemiol Glob Health

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Introduction To evaluate the impact of COVID-19 mitigation measures on the total number of consultations for respiratory and gastrointestinal infections among children under 16 years in Thai Binh Pediatric Hospital, Vietnam during the year 2020. Methods A retrospective study was carried out to review consecutive consultations occurring in children admitted from January 01, 2016 to December 31, 2020. All medical records were collected from the central numeric database of the hospital. Diagnoses were documented according to the International Classification of Diseases 10 criteria. Results 436,276 children consulted at the outpatient department during the period of study. A gradual increase in the total number of outpatients was observed from 2016 to 2019, including those consulting for respiratory and gastrointestinal infections. However, the total number of outpatients and the numbers of those consulting for respiratory and gastrointestinal infections dramatically decreased in 2020. A significant decrease of respiratory infections relative proportion was observed in 2020 when compared to 2016–2019 (p < 0.0001). By contrast, the relative proportion of gastrointestinal infections did not significantly vary (p = 0.91). The proportion of outpatients aged under 5 years was significantly lower in 2020 compared to previous years (p < 0.0001). The proportion of male patients was significantly higher in 2020 than from 2016 to 2019 (p = 0.001). Conclusion Public health measures against the COVID-19 pandemic likely decreased the prevalence of other respiratory tract infections. Further studies are needed to validate the effectiveness of each type of measure. Microbiological studies are also recommended, to better understand the effect of preventive measures.

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Morbidity and Mortality Patterns in Children Admitted to Hospital in Thai Binh, Vietnam: A Five-year Descriptive Study with a Focus on Infectious Diseases

Cited by 9 publications

References 27 publications

Aetiology of Acute Undifferentiated Fever Among Children Under the Age of Five in Vietnam: A Prospective Study

Aetiology of Acute Undifferentiated Fever Among Children Under the Age of Five in Vietnam: A Prospective Study

Outbreak of central nervous system infections among children in Thai Binh, Viet Nam

Effect of the COVID-19 Outbreak on the Incidence of Other Respiratory and Gastrointestinal Infections in Children in Thai Binh, Vietnam in 2020

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