Morbidity and mortality in patients with coronary artery disease undergoing orthotopic liver transplantation

Plotkin, Jeffrey S.; Scott, Victor F.; Pinna, A.D.; Dobsch, Brent P.; DeWolf, AM; Kang, Yisheng

doi:10.1016/s0928-4346(97)85773-8

Cited by 106 publications

(150 citation statements)

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“…As noted, the study of Plotkin et al 20 showed that patients with significant CAD do not fare well after OLT. Therefore, a potentially attractive alternative is to treat CAD before OLT.…”

Section: Treatment Of Cad In Patients With Esldmentioning

confidence: 91%

“…Plotkin et al, 20 in a retrospective study of 32 patients with known CAD who underwent OLT, found an overall mortality rate of 50% and morbidity rate of 81%. Twenty patients had undergone CABG between 6 months and 12 years before OLT, 2 patients had undergone simul- taneous CABG and OLT, 9 patients were managed medically, and 1 patient had undergone PTCA 4 years before OLT.…”

Section: Outcome Of Olt In Patients With Esld and Coexistent Cadmentioning

confidence: 99%

“…The high rates of morbidity and mortality in patients with known CAD undergoing OLT detailed by Plotkin et al 20 have led to a consideration that 15 found diabetes mellitus to be the only independent risk factor that predicted the presence of significant CAD in patients with ESLD. In addition, patients with diabetes can develop cardiac ischemia in the absence of symptoms more commonly than patients without diabetes.…”

Section: Screening For Cad In Patients With Esldmentioning

confidence: 99%

“…Given the poor outcomes of patients with active CAD who undergo OLT, noted by Plotkin et al, 20 all patients with significant obstructive CAD found on preoperative screening should be treated before undergoing OLT. Treatment should include aggressive medical management of CAD, as detailed.…”

Section: Treatment Synopsismentioning

confidence: 99%

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Detection and treatment of coronary artery disease in liver transplant candidates

Keeffe

Valantine

Keeffe

2001

Liver Transplantation

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“…As noted, the study of Plotkin et al 20 showed that patients with significant CAD do not fare well after OLT. Therefore, a potentially attractive alternative is to treat CAD before OLT.…”

Section: Treatment Of Cad In Patients With Esldmentioning

confidence: 91%

Section: Outcome Of Olt In Patients With Esld and Coexistent Cadmentioning

confidence: 99%

Section: Screening For Cad In Patients With Esldmentioning

confidence: 99%

Section: Treatment Synopsismentioning

confidence: 99%

See 2 more Smart Citations

Detection and treatment of coronary artery disease in liver transplant candidates

Keeffe

Valantine

Keeffe

2001

Liver Transplantation

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“…However, we found an overall prevalence of 16.2% of severe coronary artery disease (obstruction greater than 70% obstruction of the coronary arteries) in patients older than 50 years in the preoperative evaluation for liver transplantation, diagnosed by catheterization 5 . Plotkin et al 6 found, based on cardiac catheterization and dobutamine stress echocardiography, 5% of significant coronary artery disease (with obstruction of 70% or more of the coronary arteries) in patients older than 40 6 .…”

Section: Introductionmentioning

confidence: 99%

Doença coronária obstrutiva em hepatopatas crônicos que aguardam transplante hepático

Godoy

Roveri

Santos

et al. 2011

Arq. Bras. Cardiol.

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Outcome of Liver Transplantation in Septuagenarians

Lipshutz¹

2007

Arch Surg

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Hypothesis: We hypothesized that selected septuagenarians may do as well after transplantation as those of a younger group of older recipients. This work compares post-liver transplant survival in septuagenarians with that of patients aged 50 to 59 years. Design: Review of a prospectively maintained database. Setting: University transplant center. Patients: First-time liver transplant recipients treated from January 1, 1988, to December 31, 2005. Group 1 consisted of liver transplant recipients aged 70 years or older at the time of transplant. Group 2 was a younger cohort of patients aged 50 to 59 years. Interventions: Liver transplantation. Main Outcome Measures: Patient survival. Survival data were stratified, Kaplan-Meier survival was calculated, and a multivariate analysis was performed. Results: Group 1 included 62 patients aged 70 years or older (average, 71.9±2.1 years). Group 2 included 864 patients aged 50 to 59 years (average, 54.3±2.9 years). Unadjusted patient survival of group 1 at 1, 3, 5, and 10 years was 73.3%, 65.8%, 47.1%, and 39.7%, respectively. Unadjusted patient survival of group 2 at 1, 3, 5, and 10 years was 79.4%, 71.5%, 65.3%, and 45.2%, respectively. The difference was not statistically significant (P =.14). Multivariate analysis for factors affecting survival demonstrated preoperative hospitalization, cold ischemia time, and hepatitis C/ethanol as risk factors for death. Age 70 years or more was not a strong risk factor (mortality ratio, 1.28; P=.27). Conclusions: When other risk factors for mortality are controlled in older recipients, risk of death due to age is reduced in well-selected recipients. Age by itself should not be used to limit liver transplantation.

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Morbidity and mortality in patients with coronary artery disease undergoing orthotopic liver transplantation

Cited by 106 publications

References 1 publication

Detection and treatment of coronary artery disease in liver transplant candidates

Detection and treatment of coronary artery disease in liver transplant candidates

Doença coronária obstrutiva em hepatopatas crônicos que aguardam transplante hepático

Outcome of Liver Transplantation in Septuagenarians

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