Morbid Obesity and Gastric Bypass Surgery: Biochemical Profile

Silvestre, V.; Ruano, M; Domínguez, Yuri Arnold; Castro, Rafael; García-Lescun, MC G; Rodríguez, Ana; Marco, Alberto; García-Blanch, G

doi:10.1381/0960892042387048

Cited by 24 publications

(11 citation statements)

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“…These improvements are part of the many beneficial effects of weight loss, and RYGB induced weight loss in particular. The decrease in HDL in our study, although not a beneficial effect of RYGB, has been reported in human studies in the early post-operative state with increases later in recovery [11,12]. Interestingly, the metabolic parameters in SH rats were not significantly different from SC and RYGB-operated rats at time of sacrifice.…”

Section: Discussionsupporting

confidence: 52%

A rat model of childhood diet-induced obesity: Roux-en-Y gastric bypass induced changes in metabolic parameters and gastric peptide ghrelin

et al. 2007

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Childhood morbid obesity is reaching epidemic proportions. Roux-en-Y gastric bypass (RYGB) results in many metabolic alterations, including changes in glucose and lipid metabolism, and changes in levels of the gastric hormone, ghrelin. As more children are undergoing RYGB, an animal model would be beneficial to further study RYGB and its subsequent metabolic effects. DIO Sprague Dawley rats underwent RYGB, sham jejunojejunostomy (SH), or no operation (HFC) after 6 weeks of high-fat diet. Non-obese rats fed standard chow (SC) were a final control group. Animals were post-operatively fed standard chow for 7 days before sacrifice. At sacrifice, venous blood and gastric mucosa was collected for metabolic parameters and ghrelin determination. RYGB rats weighed less than SH and HFC (361 +/- 8.8 vs. 437 +/- 9.3 and 443 +/- 6.2 g, P < 0.05). Compared to HFC, RYGB animals had decreased plasma glucose (292 +/- 23 vs. 141 +/- 10 mg/dL), cholesterol (80 +/- 12 vs. 45 +/- 5 mg/dL), triglycerides (138 +/- 37 vs. 52 +/- 7 mg/dL), HDL (43 +/- 5 vs. 20 +/- 3 mg/dL), and free fatty acids (0.72 +/- 0.14 vs. 0.23 +/- 0.02 mEq/L), all P < 0.05. Plasma ghrelin increased in RYGB rats compared to SC and HFC (116.22 +/- 32.27 vs. 31.60 +/- 2.66 and 31.75 +/- 0.75 pg/mL, P < 0.05). In a rat model of RYGB, we demonstrated improved metabolic parameters and increased plasma and gastric mRNA ghrelin levels. The rat model for RYBG appears to be a reasonable model for future study of the cellular and molecular regulatory pathways of obesity and its surgical treatment.

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Section: Discussionsupporting

confidence: 52%

A rat model of childhood diet-induced obesity: Roux-en-Y gastric bypass induced changes in metabolic parameters and gastric peptide ghrelin

et al. 2007

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“…The increased synthesis of triglycerides in the liver and decreased production of HDL-C may trigger dyslipidemia as well as more susceptibility to atherosclerosis. This sense, the decrease of insulin and glucose favors the improvement of lipid profile after bariatric surgery (41) . In the present study, it was observed an improvement in lipid fractions after bariatric bypass.…”

Section: Discussionmentioning

confidence: 99%

AGE AND GENDER MAY INFLUENCE THE RESULTS OF ROUX-EN-Y GASTRIC BYPASS? Metabolic syndrome parameters

Andrade-Silva

Caranti

Sallet³

et al. 2014

Arq. Gastroenterol.

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-Context -Severe obesity affects the body favoring the development of serious diseases, including hypertension, diabetes mellitus, atherosclerosis and non alcoholic fatty liver disease. Bariatric procedures increased in Brazil in the last decade. Objectives -The purpose of this study was to verify if gender and age in date of procedure resulted significant differences in metabolic syndrome parameters after surgery. Methods -The study involved 205 medical records of adult patients undergoing Roux-en-Y gastric bypass, stratified by gender and age groups and followed one year by a multidisciplinary team. Results -It was observed significant decrease in body mass index, fasting glucose and insulin at all ages and both genders. Lipid profile showed significant improvements except high density lipoprotein cholesterol. Ectopic fat in the liver has decreased after 6 months in patients classified with steatosis at baseline. Patients classified as hypertensive blood pressure levels decreased 6 months after surgical intervention. Conclusion -Roux-en-Y gastric bypass proved to be an important tool in remission of metabolic syndrome parameters. The reduction of body mass accompanied to decrease in insulin resistance resulted in lower prevalence of comorbidities associated with obesity. The benefits were similar and extended both genders and all age groups between 18 and 65 years old. HEADINGS -Bariatric surgery. Metabolic syndrome X. Roux-en-Y anastomosis. Fatty liver.

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“…Sustained weight loss, reduced mortality, and improved hyperglycemia and hypertension are all advantages of BS [8][9][10][20][21][22]. As with any procedure there are risks associated with BS.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the donor, Sjostrom et al found that BS was associated with an overall reduction of mortality compared to conventional weightloss methods [20]. BS results in sustained weight loss and improves hyperinsulinemia, hyperglycemia, dyslipidemia, and hypertension even after 6 months [8][9][10]21]. Douglas et al suggested that BS is associated with protective hazard ratios for type-2 diabetes mellitus, hypertension, angina, and myocardial infarction [22].…”

Section: Transplantation After Donor Bariatric Surgerymentioning

confidence: 99%

Bariatric surgery for obese live kidney donors: an analysis of risks and benefits

Brooks¹,

Mitro²,

DeLeonibus³

et al. 2017

Integr Obesity Diabetes

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Background: Obesity can be a barrier to live donor selection and there are reports of obese live kidney donors (OLKDs) undergoing bariatric surgery prior to donation. While this practice has potential promise, the risks associated with it are unclear. Thus, our aim was to evaluate the advantages and disadvantages of this practice.Design: Risks and benefits were ascertained from the literature. Analysis of costs and benefits was performed to provide objective data for each scenario.Results: Live kidney donation is associated with superior outcomes compared to deceased donation. However, live donors are at risk of complications that could be exacerbated by obesity. Higher donor body mass index (BMI) has been associated with inferior recipient outcomes. Bariatric surgery (BS) results in decreased mortality and can induce sustained weight loss. Our cost-benefit analysis revealed a benefit-to-cost ratio of 3.64 for BS prior to live donation by OLKDs. We found ratios of 3.19 and 0.97 for live donation with an obese donor and a deceased donor, respectively. Conclusions:Our results suggest that BS for an OLKD has the potential to increase the number of live donors and improve outcomes. However, more data is required; thus we recommend a registry of patients who have undergone both procedures.

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Morbid Obesity and Gastric Bypass Surgery: Biochemical Profile

Abstract: After gastric bypass, a marked decrease in insulin occurred, with normalization of blood pressure and the biochemical parameters associated with the metabolic syndrome. We propose a biochemical follow-up protocol for MO patients.

Cited by 24 publications

References 0 publications

A rat model of childhood diet-induced obesity: Roux-en-Y gastric bypass induced changes in metabolic parameters and gastric peptide ghrelin

A rat model of childhood diet-induced obesity: Roux-en-Y gastric bypass induced changes in metabolic parameters and gastric peptide ghrelin

AGE AND GENDER MAY INFLUENCE THE RESULTS OF ROUX-EN-Y GASTRIC BYPASS? Metabolic syndrome parameters

Bariatric surgery for obese live kidney donors: an analysis of risks and benefits

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