Morada Nova sheep breed: Resistant or resilient to Haemonchus contortus infection?

Toscano, J. H. B.; Santos, Isabella Barbosa dos; Haehling, Marei Borsch von; Giraldelo, L. A.; Lopes, Louyse Gabrielli; Silva, Matheus Henrique da; Figueiredo, Amanda; Esteves, S. N.; Chagas, A. C. de S.

doi:10.1016/j.vpoa.2019.100019

Cited by 23 publications

(16 citation statements)

References 49 publications

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“…Phenotyping results of the experimental lambs were presented in detail in a previous paper 33 . Mean FEC and PCV values between resistant and susceptible phenotypes at weaning and throughout the two parasitic challenges are summarized in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 287 Morada Nova lambs (146 males and 141 females) were experimentally challenged with H. contortus and characterized as divergent resistance phenotype groups. The same individuals from the present study were used in a previous work 33 . All procedures were approved by Embrapa Southeast livestock Ethics Committee on Animal Experimentation (process no.…”

Section: Methodsmentioning

confidence: 99%

“…At weaning, lambs showed natural GIN infection (96.4% Haemonchus ), cleared by oral administration of 2.5 mg/kg of monepantel (Zolvix ® , Novartis). Fourteen days after deworming (D0), the lambs were submitted to two parasitic challenges with 4,000 H. contortus L 3 , as previously described 33 . Each challenge lasted 42 days.…”

Section: Methodsmentioning

confidence: 99%

“…The same individuals from the present study were used in a previous work. 33 All procedures were approved by Embrapa Southeast livestock Ethics Committee on Animal Experimentation (process no. 04/2017) and are in accordance with national and international ethical principles and guidelines for animal experimentation.…”

Section: Characterization Of Haemonchus Contortus Resistance Phenotmentioning

confidence: 99%

“…Fourteen days after deworming (D0), the lambs were submitted to two parasitic challenges with 4,000 H. contortus L 3 , as previously described. 33 Each challenge lasted 42 days. The flock was dewormed at D42 of the first challenge, and the second artificial infection occurred after a 14-day rest period.…”

Section: Characterization Of Haemonchus Contortus Resistance Phenotmentioning

confidence: 99%

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Local and systemic immune mediators of Morada Nova lambs with divergent Haemonchus contortus resistance phenotypes

Toscano

Okino

Santos

et al. 2020

Parasite Immunology

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Haemonchus contortus, the most pathogenic sheep parasite, is the major limiting factor for sheep farming in tropical countries, including in Brazilian territory. 1-4 As chemical control is the main tool for combating this parasite, the widespread multiple resistance of H. contortus to anthelmintics highlights the urgent need for alternative control measures, such as the selective breeding for parasite resistance or development of immune-related therapeutics. 5-8 Therefore, better understanding of the immuno-genetic mechanisms underlying this resistance is required. Immunity against helminths depends on cellular adaptive responses, through participation of T-helper lymphocytes (Th, CD4+), which are functionally grouped into two subpopulations: Th1,

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Characterization Of Haemonchus Contortus Resistance Phenotmentioning

confidence: 99%

Section: Characterization Of Haemonchus Contortus Resistance Phenotmentioning

confidence: 99%

See 3 more Smart Citations