Investigating the benefits of targeted selective treatment according to average daily weight gain against gastrointestinal nematodes in Morada Nova lambs

Santos, Isabella Barbosa dos; Anholeto, Luís Adriano; Sousa, Gustavo Avelar de; Nucci, Alessandra da Silva; Gaínza, Yousmel Alemán; Figueiredo, Amanda; Santos, Leonardo Aparecido Lima dos; Minho, Alessandro Pelegrine; Barioni-Junior, Waldomiro; Esteves, S. N.; Niciura, S. C. M.; Chagas, Ana Carolina de Souza

doi:10.1007/s00436-022-07549-w

Cited by 7 publications

(8 citation statements)

References 40 publications

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“…The results regarding GIN infection (PCV, EPG and fecal cultures) and its impact on weight gain are described more fully in a study of the consequences of different anthelmintic treatments (CT, RT and TST) on parasite control in the rainy and dry season (Santos et al, 2022). The main results are summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…Parasites from sheep intensely treated with monepantel in Brazil showed resistance to this drug within three months (Albuquerque et al, 2017). Faster establishment of resistance was also detected among Morada Nova lambs in the state of São Paulo after the third treatment with levamisole, performed every 42 days (dos Santos et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown that when TST is adopted, the interval between anthelmintic use and development of resistance is longer. This also results in less impact on the environment and less drug residues in animal products (dos Santos et al, 2022). In flocks in which TST was performed using EPG as a parameter, it took around 4.5 years for anthelmintic resistance to ivermectin to become established (Echevarria & Trindade, 1989).…”

Section: Discussionmentioning

confidence: 99%

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Economic impact of gastrointestinal nematodes in Morada Nova sheep in Brazil

Chagas

Tupy

Santos

et al. 2022

Rev. Bras. Parasitol. Vet.

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This study evaluated the economic impact of gastrointestinal nematode (GIN) infection in Morada Nova lambs under different parasite chemical control conditions. For this, 246 lambs, in the rainy and dry season, were randomized into groups according to their anthelmintic treatment with levamisole: control (CT: no treatment); routine treatment (RT: treated every 42 days); and targeted selective treatment (TST: treated according to the average daily weight gain, DWG). From 63 days of age (D63) to D210, the lambs were weighed and monitored for GIN infection parameters. Spending on anthelmintics in the production system was 1.3% of the total economic result. The economic result per animal (R$ 5.00 = US$ 1.00) was higher in the RT group, amounting to US$ 6.60 in the rainy and US$ 5.69 in the dry season, due to higher DWG. Thus, RT presented economic results 14.4% and 10.9% higher than CT, and 7.2% and 1.9% higher than TST, in the rainy and dry season, respectively. However, fast development of resistance made RT unfeasible. Here, the economic impact of GIN infection on a national scale is discussed, demonstrating its importance and the impossibility of profitable and sustainable sheep production without adequate control.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Economic impact of gastrointestinal nematodes in Morada Nova sheep in Brazil

Chagas

Tupy

Santos

et al. 2022

Rev. Bras. Parasitol. Vet.

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“…Some abomasal tissue fragments were snap frozen in liquid nitrogen and stored at −80°C until processed or submitted to histological analysis. Adult females, adult males, and L4 larvae of H. contortus were the unique specie collected in the abomasum of necropsied sheep and morphologically identified 41 …”

Section: Methodsmentioning

confidence: 99%

“…Adult females, adult males, and L4 larvae of H. contortus were the unique specie collected in the abomasum of necropsied sheep and morphologically identified. 41…”

Section: Experimental Designmentioning

confidence: 99%

Enhanced mucosal response in sheep harbouringβ^Abeta‐globin against haemonchosis

Okino,

Niciura,

Giaretta

et al. 2023

Parasite Immunology

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Association between ovine β‐globin polymorphisms and resistance against haemonchosis was described and related to the mechanism of high oxygen affinity βA ➔ βC switch during anaemia, but there are no studies regarding the involved local host responses. Phenotypic parameters and local responses were evaluated in sheep from two β‐globin haplotypes naturally infected with Haemonchus contortus. Morada Nova lambs were monitored at 63, 84 and 105 days of age for faecal egg counts and packed cell volume (PCV) under natural infection with H. contortus. At 210 days of age, lambs of Hb‐AA and Hb‐BB β‐globin haplotypes were euthanised, and the fundic region of abomasum was sampled for evaluation of microscopic lesions and relative expression of genes related to immune, mucin and lectin activities. Lambs harbouring the βA allele presented an improved resistance/resilience against clinical haemonchosis, showing higher PCV during infection. Hb‐AA animals presented increased eosinophilia in the abomasum compared to Hb‐BB animals, accompanied by higher Th2 profile, mucin and lectin activity transcripts, while the inflammatory response was increased in Hb‐BB animals. This is the first report to demonstrate an enhanced local response in the primary site of H. contortus infection related to βA allele of β‐globin haplotype.

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Revisiting anthelmintic resistance in sheep flocks from São Paulo State, Brazil

Bassetto,

Albuquerque,

Lins

et al. 2024

International Journal for Parasitology: Drugs and Drug Resistan

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Investigating the benefits of targeted selective treatment according to average daily weight gain against gastrointestinal nematodes in Morada Nova lambs

Cited by 7 publications

References 40 publications

Economic impact of gastrointestinal nematodes in Morada Nova sheep in Brazil

Economic impact of gastrointestinal nematodes in Morada Nova sheep in Brazil

Enhanced mucosal response in sheep harbouringβ^Abeta‐globin against haemonchosis

Revisiting anthelmintic resistance in sheep flocks from São Paulo State, Brazil

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Investigating the benefits of targeted selective treatment according to average daily weight gain against gastrointestinal nematodes in Morada Nova lambs

Cited by 7 publications

References 40 publications

Economic impact of gastrointestinal nematodes in Morada Nova sheep in Brazil

Economic impact of gastrointestinal nematodes in Morada Nova sheep in Brazil

Enhanced mucosal response in sheep harbouringβAbeta‐globin against haemonchosis

Revisiting anthelmintic resistance in sheep flocks from São Paulo State, Brazil

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Product

Resources

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Enhanced mucosal response in sheep harbouringβ^Abeta‐globin against haemonchosis