Mood-worsening with high-pollen-counts and seasonality: A preliminary report

Guzmán, Alvaro; Tonelli, Leonardo H.; Roberts, Darryl W.; Stiller, John W.; Jackson, Michael; Soriano, Joseph J.; Yousufi, Samina M.; Rohan, Kelly J.; Komarow, Hirsh D.; Postolache, Teodor T.

doi:10.1016/j.jad.2006.11.026

Cited by 26 publications

(27 citation statements)

References 50 publications

(42 reference statements)

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“…In a self-report study, self-reported lower moods were associated with high pollen counts, with seasonality different than seasonal affective disorder (i.e., fall-winter mood worsening) [120]. Subjective worsening of mood with high pollen counts, which is similar to season of pollen exposure, has been reported previously in college students [121].…”

Section: Ar and Depressionmentioning

confidence: 75%

Mental Health in Allergic Rhinitis: Depression and Suicidal Behavior

Amritwar

Lowry

Brenner³

et al. 2017

Curr Treat Options Allergy

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Opinion Statement A high proportion of suicides visit their medical provider in the month prior to death, but depression, suicidal thoughts, and substance use are seldom addressed. For the clinicians routinely treating a substantial patient population with allergic diseases, there are additional concerns, as allergy has been linked with both depression and suicidal behavior. While psychotropic medications may affect diagnosis of allergies, medications used to treat allergies impact mood and behavior. Thus, we present an overview of the overlap of allergic rhinitis with depression and suicidal behavior in adults, based on clinical and epidemiological data, and our research and clinical experience. In summary, we suggest: 1) inquiring among patients with allergies about personal and family history of depression, substance use disorders, suicidal ideation and attempts 2) increased mindfulness regarding the potential effects of allergy medications on mood and behavior; and 3) for people identified with certain types of depression or increased suicide risk, a systematic multilevel collaborative approach. While for practical reasons the majority of patients with depression will continue to be treated by general or family practitioners, the allergy-treating provider should always consider integrated care for bipolar, psychotic or suicidal depression and incomplete remission, or relapsing and highly recurrent course. While awaiting results of much needed basic and clinical research to guide clinical approach for patients with comorbid allergic rhinitis and depression, the simple steps recommended here are expected to improved clinical outcomes in depression, including, on a large scale, reduced premature deaths by suicide.

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Section: Ar and Depressionmentioning

confidence: 75%

Mental Health in Allergic Rhinitis: Depression and Suicidal Behavior

Amritwar

Lowry

Brenner³

et al. 2017

Curr Treat Options Allergy

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“…It is possible that the latitude and bioclimatic differences between the two countries could explain the contradictory results. Alternative biological factors have been proposed as triggers of suicide in spring, such as the marked tree pollen peaks in spring (Postolache et al 2005) which could result in seasonally increased cytokine production in upper airways resulting in increased exacerbation of mood disturbance in spring (Guzman et al 2007). Consistent with these hypotheses, intranasal tree pollen administration in previously sensitized rodents results in increased cytokine expression in the brain and behavioral alterations consisting of increased anxiety and disturbed social interaction (Tonelli et al 2009) .…”

Section: Discussionmentioning

confidence: 99%

Seasonal spring peaks of suicide in victims with and without prior history of hospitalization for mood disorders

Postolache

Mortensen

Tonelli

et al. 2010

Journal of Affective Disorders

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“…17 Several recent studies have suggested associations between mood disorders or suicidality and a seasonal presentation associated with pollen counts. [19][20][21][22] A recent review discusses the evidence for a link between allergy and depression and notes the available reports on possible relationships between allergy, montelukast, and suicidality. 23 Acknowledging these background rates of suicidality in the general population and the apparently higher rates of suicidality in the asthmatic and allergic populations, it could be anticipated that some patients being treated for asthma or allergic rhinitis with montelukast could report suicidal ideation or behavior.…”

Section: Discussionmentioning

confidence: 99%