Mood‐Related Drinking Motives Mediate the Familial Association Between Major Depression and Alcohol Dependence

Young-Wolff, Kelly C.; Kendler, Kenneth S.; Sintov, Nicole D.; Prescott, Carol A.

doi:10.1111/j.1530-0277.2009.00978.x

Cited by 45 publications

(52 citation statements)

References 68 publications

(74 reference statements)

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“…Family history of AUDs is known to confer high risk for mood disorders, and mood disorders may lead to AUDs (9, 35–37). For instance, Young-Wolff and colleagues' (38) finding that the use of alcohol to improve mood mediated the relationship between depression and AUDs provides support for the “self-medication” hypothesis. The development of AUDs among individuals with mood disorders may in some cases be the result of chronic alcohol use to suppress mood disorder symptomology (39–41).…”

Section: Introductionmentioning

confidence: 99%

Pathways to Vulnerability for Alcohol Problem Severity in a Treatment-seeking Sample

Eddie

Hunter‐Reel

Epstein

et al. 2015

Addictive Disorders &Amp; Their Treatment

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Objectives The present investigation examined the role of gender, family history of alcohol and drug use disorders, temperament, childhood behavior problems, and adult psychopathology, on adult alcohol use disorder (AUD) severity. Methods Structural equation modeling was used to examine multiple etiological pathways to adult alcohol use disorder (AUD) severity. Participants included 335 treatment-seeking males and females with current or lifetime DSM-III-R alcohol dependence (96%) or abuse (4%) enrolled in one of five treatment outcome studies. Extensive assessment at treatment entry used a mixture of retrospective and current self-report. Results Results identified two significant paths associated with a latent factor of adult alcohol use disorder severity at entry to treatment. In Path 1, male gender and family history of drug use disorder predicted greater childhood behavior problems, which predicted antisocial personality disorder (ASPD), borderline personality disorder (BPD), and anxiety disorders (ADs), with anxiety disorders leading directly to alcohol use disorder severity. In Path 2, family history of alcohol use disorder predicted difficult temperament in childhood, which predicted borderline personality disorder, major depressive disorder (MDD) and anxiety disorders; both major depressive disorder and anxiety disorders in turn predicted alcohol use disorder severity at treatment entry. Conclusions The present findings build on the literature on heterogeneity in developmental risk processes leading to the expression of adult alcohol use disorder symptomology among patients presenting for alcohol use disorder treatment.

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Section: Introductionmentioning

confidence: 99%

Pathways to Vulnerability for Alcohol Problem Severity in a Treatment-seeking Sample

Eddie

Hunter‐Reel

Epstein

et al. 2015

Addictive Disorders &Amp; Their Treatment

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show abstract

“…For example, in a sample of 5,000 adults age 30 and older, Young-Wolff, Kendler, Sintov, and Prescott (2009) revealed that familial factors underlying drinking to manage mood accounted for essentially all of the genetic and common environmental overlap of mood disorder and alcohol dependence. Although coping motives might be tied similarly to depression and other distressing emotions caused or exacerbated by withdrawal symptoms from substance use, these motives could also be etiologically significant in that they signal a more primary predisposition toward mood disorders and substance abuse.…”

Section: Implications For Comorbidity Theory and Researchmentioning

confidence: 98%

Substance Use Motives in People With Severe Mental Illness: Comparisons Among Four Diagnostic Groups

O’Hare

Sherrer

2012

Journal of Social Work Practice in the Addictions

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Research has consistently shown that alcohol consumption motivated by a desire to alleviate negative emotional states predicts alcohol use and relapse among clients with cooccurring psychiatric disorders. However, studies examining the role of drinking motives in people with severe mental illness are few. This study of 283 community mental health clients (43.8% men, 55.1% women), assigned a primary Axis I diagnosis of schizophrenia (28.3%), schizoaffective (23.3%), major depression (31.1%), or bipolar I disorder (17.3%), tested the hypothesis that clients with a diagnosis of mood disorder would report greater substance use, would indicate more problems associated with substance use, and would be more likely to use substances to cope with negative emotions than would clients with schizophrenia. In addition, coping motives would account for more variance in substance use and related problems than would convivial drinking when controlling for age, gender, and Axis I diagnosis. Results largely supported these hypotheses with some exceptions. Implications for theory, research, and practice with comorbid clients are suggested.

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“…After the purpose of this research procedure has been explained, the person who will be interviewed must be informed that this phone call will be recorded. The objectives of the study will be explained, specifying the approximate duration of the interaction [7,13 ]. Authorization to participate in the study will be documented by recording this telephone interaction and could be transcribed for filing purposes.…”

Section: Interviews By Telephonementioning

confidence: 99%

“…The Informed Consent Form is signed and dated before the participant begins any research activity. This is the process most widely used to obtain consent in research settings [4][5][6][7].…”

Section: Usual Informed Consent Processmentioning

confidence: 99%

Ethical, legal and social issues related to alcohol and drug research

Goldim

Fernandes

Pechansky

2011

Current Opinion in Psychiatry

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Mood‐Related Drinking Motives Mediate the Familial Association Between Major Depression and Alcohol Dependence

Cited by 45 publications

References 68 publications

Pathways to Vulnerability for Alcohol Problem Severity in a Treatment-seeking Sample

Pathways to Vulnerability for Alcohol Problem Severity in a Treatment-seeking Sample

Substance Use Motives in People With Severe Mental Illness: Comparisons Among Four Diagnostic Groups

Ethical, legal and social issues related to alcohol and drug research

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