Children who are separate from one or both of their parents (parental separation) have a higher tendency to experience stress, mental health problems, and self-harm behavior. Self-harm behavior is the practice of deliberately injuring body tissue generally carried out by oneself without the intention of committing suicide or without the purpose of social sanctions. Personality is one of the factors that drive an individual to practice selfharm. An individual who has a dominant neuroticism personality has problems in anxiety, hostility, depression, impulsive behavior, self-consciousness, and vulnerability. Moreover, previous studies states that an individual with high levels of openness and neuroticism but low levels of agreeableness and conscientiousness has a higher tendency to practice self-harm. Self-harm behavior occurs because an individual cannot control his/her impulses when dealing with unpleasant conditions. An individual practices self-harm to reduce the negative feelings within his/herself because of the unpleasant conditions. This study reviewed 20 articles with a systematic literature review method. This study found that there was a relationship between self-harm behavior, neuroticism personality, and parental separation. It was due to that impulsivity was a one of the characteristics in neuroticism personality which an individual with a dominant neuroticism personality had a problem to control his/her impulses. Parental separation also causes self-harm behavior because it created trauma on children.