Mood disorders, childhood maltreatment, and medical morbidity in US adults: An observational study

Stapp, Emma K.; Williams, Stacey; Kalb, Luther G.; Holingue, Calliope; Eck, Kathryn Van; Ballard, Elizabeth D.; Merikangas, Kathleen R.; Gallo, Joseph J.

doi:10.1016/j.jpsychores.2020.110207

Cited by 9 publications

(5 citation statements)

References 88 publications

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“…Childhood maltreatment is related with varies mental diseases in adulthood (9,10), including psychosis (11), mood disorders (12), anxiety disorders (13), and PDs (14, 15). To date, many empirical studies have explored the connection between different types of CM (i.e., emotional abuse, physical abuse, sexual abuse, emotional neglect, and physical neglect) and BPD (9,14,(16)(17)(18)(19)(20)(21)(22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%

Specific type of childhood trauma and borderline personality disorder in Chinese patients

Zheng

Wang

et al. 2022

Front. Psychiatry

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BackgroundChildhood maltreatment (CM) is a known risk factor for the development of mental disorders. An extensive body of literature about CM and mental health has been developed in wealthy countries, but information about this connection is lacking in developing countries including China.AimsTo explore the possible relationship between specific types of CM and borderline personality disorder (BPD) in patients with mental disorders in China.MethodsA survey was conducted in 2006, involving over 3,402 Chinese individuals aged 18–60 years who were randomly selected from the outpatients in the Shanghai Mental Health Center. The patients were screened with the Personality Diagnostic Questionnaire and CM was assessed using the Childhood Trauma Questionnaire. The final sample comprised 178 patients with BPD, 178 patients with other personality disorders (PDs), and 178 patients without PDs.ResultsIn Chinese patients, compared to other PDs, patients with BPDs are more likely to have experienced CM. Emotional maltreatment (emotional abuse and neglect) was the strongest predictor of BPD. Female gender and sexual abuse are significant predictors of the self-harm/suicidal risk of BPD patients.ConclusionThis is a pioneering study conducted on a large set of Chinese clinical samples with paired controls to establish and compare the associations between specific CM and BPD. Further studies in this field are necessary to elucidate the mechanism of how various types of childhood trauma have influenced PDs.

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Section: Introductionmentioning

confidence: 99%

Specific type of childhood trauma and borderline personality disorder in Chinese patients

Zheng

Wang

et al. 2022

Front. Psychiatry

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“…Our multi-measure construct of FE focused on familial climate overall, not limited to abuse, per se-the latter of which is at the extreme negative end of caregiving behaviors. That being said, some youth in our study who experienced high levels of conflict, rigidity, and low warmth may conceivably be experiencing FE that overlaps with maltreatment, which has been shown to have detrimental effects on health over the life course (Lippard & Nemeroff, 2020;Palmier-Claus et al, 2016;Stapp, Williams et al, 2020). Taken together, a small but converging body of evidence is consistent with the liability threshold model, in which lower genetic burden, in the presence of environmental stress (i.e., multifactorial), is associated with increased mood and psychotic disorder liability (Schick et al, 2022;Tonini et al, 2022).…”

Section: Discussionmentioning

confidence: 92%

Family environment and polygenic risk in the bipolar high‐risk context

et al. 2023

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Background:The interaction of polygenic risk (PRS) and environmental effects on development of bipolar disorder (BD) is understudied, as are high-risk offspring perceptions of their family environment (FE). We tested the association of offspring-perceived FE in interaction with BD-PRS on liability for BD in offspring at high or low familial risk for BD.Methods: Offspring of a parent with BD (oBD; n = 266) or no psychiatric disorders (n = 174), aged 12-21 at recruitment, participated in the US and Australia.Empirically-derived profiles of FE classified offspring by their perceived levels of familial cohesion, flexibility, and conflict. Offspring BD-PRS were derived from Psychiatric Genomics Consortium BD-GWAS. Lifetime DSM-IV bipolar disorders were derived from the Schedule for Affective Disorders and Schizophrenia for School-Aged Children. We used a novel stepwise approach for latent class modeling with predictors and distal outcomes.Results: Fifty-two offspring were diagnosed with BD. For those with wellfunctioning FE (two-thirds of the sample), higher BD-PRS tracked positively with liability for BD. However, for those with high-conflict FEs, the relationship between BD-PRS and liability to BD was negative, with highest risk for BD observed with lower BD-PRS. In exploratory analyses, European-ancestry offspring with BD had elevated history of suicidal ideation in high-conflict FE compared to well-functioning-FE, and of suicide attempt with low-BD-PRS and highconflict FE. Conclusions:The data suggest that the relationship of BD-PRS and offspring liability for BD differed between well-functioning versus high-conflict FE, potentially in line with a multifactorial liability threshold model and supporting future study of and interventions improving family dynamics.

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“…Cross-sectional studies in the UK (248 individuals with recurrent Major Depressive Disorders (MDD) and 72 with BD) showed that childhood maltreatment – abuse or neglect – was significantly associated with an increased medical morbidity in BD, but not in MDD (Hosang, Fisher, Hodgson, Maughan, & Farmer, 2018; Hosang et al, 2017). In a large sample of adults (National Epidemiologic Survey on Alcohol and Related Conditions) with mood disorders, it was found an additive association of both mood disorders and childhood maltreatment on medical morbidity at study entry and three years later (Stapp et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Childhood maltreatment contributes to the medical morbidity of individuals with bipolar disorders

et al. 2023

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Background Individuals with bipolar disorders (BD) are at risk of premature death, mainly due to medical comorbidities. Childhood maltreatment might contribute to this medical morbidity, which remains underexplored in the literature. Methods We assessed 2891 outpatients with BD (according to DSM-IV criteria). Childhood maltreatment was assessed using the Childhood Trauma Questionnaire. Lifetime diagnoses for medical disorders were retrospectively assessed using a systematic interview and checked against medical notes. Medical morbidity was defined by the sum of medical disorders. We investigated associations between childhood maltreatment (neglect and abuse) and medical morbidity while adjusting for potential confounders. Results One quarter of individuals had no medical comorbidities, while almost half of them had at least two. Multivariable regression showed that childhood maltreatment (mainly abuse, but also sexual abuse) was associated with a higher medical morbidity. Medical morbidity was also associated with sex, age, body mass index, sleep disturbances, lifetime anxiety disorders and lifetime density of mood episodes. Childhood maltreatment was associated with an increased prevalence of four (i.e. migraine/headache, drug eruption, duodenal ulcer, and thyroid diseases) of the fifteen most frequent medical disorders, however with no difference in terms of age at onset. Conclusions This large cross-sectional study confirmed a high medical morbidity in BD and its association with childhood maltreatment. The assessment of childhood maltreatment in individuals with BD should be systematically included in routine care and the potential impact on physical health of psycho-social interventions targeting childhood maltreatment and its consequences should be evaluated.

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Mood disorders, childhood maltreatment, and medical morbidity in US adults: An observational study

Cited by 9 publications

References 88 publications

Specific type of childhood trauma and borderline personality disorder in Chinese patients

Specific type of childhood trauma and borderline personality disorder in Chinese patients

Family environment and polygenic risk in the bipolar high‐risk context

Childhood maltreatment contributes to the medical morbidity of individuals with bipolar disorders

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