Mood Disorders and Their Treatment in Patients With Epilepsy

Prueter, Christian; Norra, Christine

doi:10.1176/jnp.17.1.20

Cited by 53 publications

(23 citation statements)

References 77 publications

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“…Les antiépileptiques fortement dépressogènes sont le phé-nobarbital (Gardenal ® ), la phénytoïne (Di-hydan ® ), le topiramate (Epitomax ® ), la tiagabine (Gabitril ® ), le felbamate (Taloxa ® ) et le vigabatrin (Sabril ® ) [86]. La primidone (Mysoline ® ) peut entraîner des conduites suicidaires impulsives.…”

Section: Cas Particulier : Antidépresseurs Et Tumeurs Cérébralesunclassified

“…En pratique, devant un patient dépressif présentant une tumeur cérébrale avec un risque de crises comitiales ou sous antiépileptiques, le citalopram (Seropram ® ), l'escitalopram (Seroplex ® ) et la sertraline (Zoloft ® ) seront considérés comme les antidépresseurs de première intention en raison de leurs faibles interactions avec les antiépileptiques et leur faible impact sur l'abaissement du seuil épileptogène [86].…”

Section: Cas Particulier : Antidépresseurs Et Tumeurs Cérébralesunclassified

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Antidepressants in oncology: specificity’s and particularities

Reich

2010

Psycho Oncologie

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Les antidépresseurs font partie de l'arsenal pharmacologique classique du traitement des états dépressifs et anxieux. Dans le champ de l'oncologie, outre la dépression, ils comportent d'autres indications potentielles telles que les bouffées vasomotrices induites par l'hormonothérapie ou certaines douleurs neuropathiques liées au cancer ou à ses traitements (chirurgicaux ou chimiothérapies). Certaines particularités propres à leur utilisation en oncologie, les interactions pharmacologiques ainsi que les modalités de leur prescription sont à connaître. Afin d'optimaliser l'action des antidépresseurs, leur usage sera le plus souvent fait en association avec un traitement psychothérapeutique adapté. Enfin, le risque carcinologique des antidépresseurs, au regard des données actuelles de la littérature, reste hypothé-tique et ne doit pas faire occulter leurs avantages lorsqu'ils sont prescrits de façon adéquate.Abstract Antidepressants are part of the classical pharmacological armament of depressive and anxiety disorders. In the oncologic field, besides depression, they might have others potential indications such as hot flushes induced by hormonotherapy or some neuropathic pain related to the cancer or its treatment (surgery or chemotherapy). Some specific particularities due to their use in oncology, the pharmacological interactions and the modalities of their prescription should be known. In order to increase the antidepressant action, their prescription will most of the time be done in association with an adapted psychotherapeutic intervention. Last, the antidepressant carcinologic risk, regarding the present literature data, remains hypothetical and must not conceal their advantages when they are adequately prescribed.

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Section: Cas Particulier : Antidépresseurs Et Tumeurs Cérébralesunclassified

Antidepressants in oncology: specificity’s and particularities

Reich

2010

Psycho Oncologie

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“…During recent years, a number of authors have approached the clinical problem of treating mood disorders in epilepsy from different points of view. [28][29][30] A few open studies have been published about the efficacy of sertraline, 31,32 citalopram, [33][34][35] reboxetine, 34 mirtazapine 34 and fluoxetine. 32 The study by Thomè-Souza et al 32 is of particular interest because it is the only published paper involving children and adolescents with epilepsy and depression.…”

Section: Treatment Strategies For Depression In Epilepsymentioning

confidence: 99%

Depression in Epilepsy Mechanisms and Therapeutic Approaches

Mula¹,

Schmitz²

2007

European Neurological Review

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It has been known for a long time that there are associations between epilepsy and depression, and there are several reasons why the two disorders may be closely linked. Epilepsy is a chronic disorder that brings about social restrictions and discrimination. As with any chronic disorder, epilepsy may be expected to be linked to demoralisation and a negative perspective on life. Furthermore, patients with epilepsy run the unpredictable risk of becoming unconscious. This can mean that they fall and hurt themselves and/or suffer social embarrassment. Recent research, while reinforcing this association, has also pointed out a biological contribution to the association based on neuroanatomical and neurochemical principles. 1 Associations between antiepileptic drug prescription and depression have been another focus of attention. 2 Epilepsy and Depression -A Bi-directional RelationshipAssessing the prevalence of depression from selected clinical samples of patients with epilepsy shows a bias towards the more severely affected subjects. A better understanding of co-morbid psychopathology comes from community studies. Edeh and Toone 3 carried out a general practice study in the UK and reported that 22% of unselected patients with epilepsy were diagnosed as having a depressive disorder. A Canadian Community Health Survey (CCHS) examined 253 people with epilepsy using a rating scale to identify a history of depression. The authors noted a 22% lifetime prevalence of depression that was much higher than the 12% prevalence rate reported in the general population. 4 More recently, Ettinger et al. 5 assessed depression in 775 subjects with epilepsy and compared the prevalence rates with those of patients with asthma and with healthy controls. In this study a rating scale assessment was also used (the Center For Epidemiological Studies -Depression Scale [CESD]). Symptoms of depression were significantly more frequent in the epilepsy group (36.5%) compared with those with asthma (27.8%) and controls (11.8%).Several studies have noted a correlation between depression and seizure frequency. In an epidemiological study, Jacoby et al. 6 noted that depression occurred in 4% of seizure-free patients and in 10% of patients suffering less than one seizure a month, but at a rate of 21% in patients with higher seizure frequency. O'Donoghue et al. 7 noted that patients with epilepsy and continuing seizures were significantly more likely to suffer from depression than those in remission (33 versus 6%).There are a number of studies from selected patient groups that noted an even higher frequency of depression in these populations. Victoroff et al. 8 examined 199 patients from five epilepsy centres, again using a structured clinical interview, the Mini International Neurophychiatric Interview (MINI), and noted that 34% met diagnostic criteria for a mood or anxiety disorder and 19% met criteria for major depression.Ring et al. 10 examined 60 patients awaiting temporal lobe epilepsy surgery, and reported at pre-operative assessment that a maj...

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“…Unlike other antidepressants, SSRIs have rarely been reported to induce seizures. Preuter and Norra [67] concluded, in a recent literature review of mood disorders and their treatment in epileptics, that SSRIs could be safely recommended as a first-line treatment in patients with epilepsy.…”

Section: Epilepsymentioning

confidence: 99%

Update on depression in neurologic illness: Stroke, epilepsy, and multiple sclerosis

Sobel

Lotkowski²,

Mandel³

2005

Curr Psychiatry Rep

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The risk of depression is increased in chronic neurologic illness and can adversely affect the course of disease. Recent literature is reviewed for depression in stroke, epilepsy, and multiple sclerosis. Depression can share pathophysiologic aspects of the comorbid illness, such as neurotransmitter pathway disturbances, hypothalamus-pituitary-adrenal pathway disturbances, and changes in immunologic function. Depression also can be a psychologic reaction to the burden of the neurologic condition. Risk factors for development of depression are reviewed. Depression and other medical conditions can have shared symptoms (eg, fatigue, psychomotor retardation) that can complicate the diagnosis of depression in neurologic illness. Proper selection of antidepressant treatment is necessary to avoid worsening the neurologic disorder.

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Mood Disorders and Their Treatment in Patients With Epilepsy

Cited by 53 publications

References 77 publications

Antidepressants in oncology: specificity’s and particularities

Antidepressants in oncology: specificity’s and particularities

Depression in Epilepsy Mechanisms and Therapeutic Approaches

Update on depression in neurologic illness: Stroke, epilepsy, and multiple sclerosis

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